Posted by admin on Nov 30, 2021 in |
Mucormycosis is an opportunistic fungal infection caused by a member of the order Mucorales. It is an angio-invasive fungal infection because of its propensity to invade blood vessel walls, resulting in catastrophic tissue ischemia (restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism), infarct (tissue death that is necrosis) due to inadequate blood supply to the affected area. Mucorales fungi are distributed worldwide and found in soil and decaying organic substrates. The most common microbiologically confirmed infecting members of the order Mucorales are Rhizopus, Mucor, Cunninghamella bertholletiae, Apophysomyces elegans, Absidia, Saksenaea and Rhizomucor pusillus. The incidence of mucormycosis has increased significantly in patients with diabetes which is the commonest underlying risk factor globally. Recently, COVID-19 caused by SARS CoV-2 has further worsened the incidence of this disease. Diagnosis of mucormycosis remains challenging. The clinical approach to diagnosis has a low sensitivity and specificity; however, it helps raise suspicion and prompt the initiation of laboratory testing. Histopathology, direct examination, and culture remain essential tools,...
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Posted by admin on Nov 30, 2021 in |
Usage of medicinal plants for the treatment of various diseases had been started from 1500 BC onwards. Loss of cognition is one of the age-related mental problems and a characteristic symptom of neurodegenerative disorders like Alzheimer’s. Various natural drugs are used for treatment of Alzheimer’s and Parkinsonism, but Available drugs provide symptomatic treatment with known side effects. So the present study is aimed to evaluate anti-amnesic activities of ethanolic flower extract of Ixora coccinea on mouse model as an attempt to search for new compounds against Alzheimer’s disease-related memory impairment. Ixora coccinea is a common flowering shrub native to Southern India and Sri Lanka. Traditionally it is used as hepatoprotective, antimicrobial, anti-oxidant, anti-nociceptive, anti-mitotic and anti-inflammatory activities. Decoction of roots was used for nausea, hiccups, and anorexia. Numerous activities were reported on the entire plant and various parts of the plant like root, leaf, and flower .The anti-amnesic activity was screened by the stair case method and elevated plus maze method. The staircase method has been widely used in...
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Posted by admin on Nov 30, 2021 in |
Cancer is a dreadful disease all over the world. The death rate had been increasing because of different types of cancers even though several drugs, treatment models and regimens are invented by scientists. Natural drugs have been showing remarkable results in the treatment of different cancers with less or no side effects. Advancements in screening methods using computer aided tools helping the researchers to discover new phytochemicals with prominent and specific activity against different diseases. The objective of the present study was to evaluate the anti-cancer potential of dichloromethane extract of Mitragyna parvifolia stem bark using MTT assay and molecular docking studies. MTT assay was performed on MCF7, A549 and HepG2 cell lines. IC50 values were found to be 402.8 μg/ml, 207.4μg/ml and 104.4μg/ml, respectively. The phytoconstituents of extract were determined by GC-MS GC-MS analysis, most probable structures were identified and named using NIST library. GC-MS study revealed 76 compounds in which acontanes, decenes, and decanoicacids are of maximum percentage. A molecular docking study was conducted on the selected...
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Posted by admin on Nov 30, 2021 in |
Pharmaceutical preparation mostly contains active ingredients and excipients. The function of excipients to improve the physicochemical properties of pharmaceutical manufacturing products. In pharmaceutical preparation, polymer plays a key role act as excipients in any dosage formulation development. Polymers are derived from the source of natural and synthetic. The polymer should have basic properties such as stable, biocompatible, non-toxic, economical, biodegradable, and hydrophilic and influence the release of the drug. For designing any pharmaceutical dosage form, the selection of polymer play a key role because due to polymer diversity. Natural polymers help in the improvement and control of the pharmacokinetics of the drug. In recent times, pharmaceutical manufacturing companies use a natural polymer to resolve the problem of side effects and drug release in sustained release formulation. The polymers which isolate naturally are mostly polysaccharides. Here in this review discussion of natural polymer source, solubility, chemical nature, and pharmaceutical application for novel drug...
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Posted by admin on Nov 30, 2021 in |
Periodontitis is a common infection occurring among a wide range of population globally. Streptococcus mutans is found to be the predominant pathogen responsible for dental caries. The present study concentrates on isolation and identification of the predominant pathogen from patients suffering from dental caries. The isolates were grown on various selective and differential media. Biochemical tests were performed to identify the pathogen. Further antibiogram assay was done to determine the sensitivity and resistance of the pathogen to several drugs. Aqueous, methanolic, and chloroform extracts of Azadirachta indica were prepared. The anti-bacterial efficacy and MIC of the extracts were evaluated. Samples were collected from 5 patients suffering from dental caries. From the morphological and biochemical observations, all the predominant isolates were found to be Streptococcus mutans. The isolates were sensitive to chloramphenicol, ciprofloxacin, Tetracycline, Gentamycin, and Methicillin. Resistance was observed for erythromycin, Penicilin, Vancomycin, Rifampicin, and cephalothin. Methanolic extracts (15 mm) showed higher inhibitory zones than the water (13 mm) and chloroform (11 mm). The MIC of the aqueous extract...
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