Posted by admin on Dec 31, 2020 in |
Diabetes and hyperlipidemia become a major risk factor for cardiovascular diseases in the world. Hyperlipidemia is a relatively common problem in patients with poorly controlled diabetes. In searching for a new class of antidiabetic and antihyperlipidemic agents, many compounds with pyridine moiety have been found to possess good activity against diabetes and hyperlipidemia. The present study was carried out to synthesize, characterize, and screening of methyl pyrimidine derivatives for antidiabetic and antihyperlipidemic activity. A novel series of 2-amino-4-(substituted phenylamino)-6-methylpyrimidine derivatives have been synthesized from Guanidine hydrochloride. Synthesized compounds were characterized by IR, MASS, 1H-NMR, and C NMR spectroscopy. Synthesized compounds were screened for antidiabetic and antihyperlipidemic activity in Swiss albino mice. The blood sample was collected and used to determine serum glucose, triglyceride, LDL (low-density lipoprotein), HDL (high-density lipoprotein), and total cholesterol level in mice. Among the synthesized derivatives, 2-amino-4-(4-methoxyphenylamino)-6-methylpyrimidine and 2-amino-4-(4-bromophenylamino)-6-methylpyrimidine shows good antidiabetic and antihyperlipidemic activity which was comparable to the standard drug, and it can be useful for the further clinical...
Read More
Posted by admin on Dec 31, 2020 in |
Urolithiasis is one of the painful urologic disorders that occurs in approximately 12% of the global population. Syzygium jambos (L.) Alston (Family: Myrtaceae), commonly known as Rose apple in English and Bogijamun in the Assamese, is an important medicinal plant found extensively in Assam and in the Indian continent. Scientific studies confirmed that the extracts of various parts possess anticancer activity, antioxidant, analgesic, antimicrobial activities, and anti-inflammatory properties. Phytochemical and Pharmacological evaluation of the Plant was carried out with special reference to antiurolithiatic activity. The in -vitro evaluation was done using growth inhibition study of struvite crystals, and in-vivo evaluation was done by Ethylene glycol induced urolithiatic model in rats. Our investigation showed that leaf extracts and ZnO-NPs prevented the growth of urinary stones. Further studies should be done to understand pharmacological action and its possible mechanism through elaborate preclinical experimentation and clinical trials in preventing urolithiasis in susceptible...
Read More
Posted by admin on Dec 31, 2020 in |
Cancer is the second leading cause of death globally. Among the group of cancer diseases, breast cancer is the most common type of cancer to affect women. The treatment options that are currently available for this include surgery, radiation therapy and therapy through medication or drugs. But, since all these are harmful and have severe side effects, drugs from natural plant compounds are being developed to act against cancer and its metastatic activity. The aim of this article is to perform qualitative and quantitative analysis of alkaloids in leaf extract of Carica papaya (CP) and also study the anticancer and anti-metastatic activity of it in MCF-7 breast cancer cell lines. CP, commonly known as papaya or papaw, belonging to the family of Caricaceae has many medicinal uses including dengue treatment, anti-inflammatory and anticancer properties. The leaf extract of CP was prepared by ethyl acetate extraction method. Various tests such as MTT assay, Wound healing assay, DNA fragmentation assay, Caspase 7/9 induction detection assay and Annexin V assay were performed...
Read More
Posted by admin on Dec 31, 2020 in |
Cobalt(II), nickel(II), copper(II) and zinc(II) complexes having the general formula ML2 (where, L= cuminaldehyde benzoyl-hydrazone, CABH) have been synthesized and characterized based on mass spectra, molar conductivity, FT-IR and UV-Vis spectral data. The complexes are found to be non-electrolytes. FT-IR data suggest that the CABH acts as a uni-negative bidentate ligand. The copper complex is investigated using ESR spectroscopy at room temperature and liquid nitrogen temperature (LNT). The spin Hamiltonian, orbital reduction, and bonding parameters are calculated for the complex. The interactions of these complexes with calf thymus DNA have been investigated using absorption spectrophotometry. The zinc complex binds DNA more strongly than cobalt, nickel or copper complexes. The metal complexes are screened for their antibacterial activity against pathogenic bacterial strains. Complexes showed higher activity than the ligand. Copper complex shows more activity than any other complexes under...
Read More
Posted by admin on Dec 31, 2020 in |
The main objective of the present research work to synthesize, characterization, and in-vivo evaluation of Pyridazine derivatives. To study the different synthesized derivatives by using different analytical parameters like IR, Mass, and NMR analysis. And also find out the antihypertensive activity. The studies on the hydralazine group drugs led to the synthesis of many Pyridazine derivatives with a wide activity spectrum on the cardiovascular system. Pyridazine derivatives, a class of compounds containing the N-N bond, exhibit a wide range of pharmacological activities such as antidepressant, antihypertensive, and cardiotonic, etc. Some 6-(substituted phenyl)-2-(substituted methyl)-4,5-dihydropyridazin-3(2H)-one derivative was synthesized by reacting 6-Phenyl substituted 2,3,4,5-Tetrahydro pyridazin-3-one with cyclic secondary amine under Mannich reaction conditions. A total of twenty compounds (vj1-vj20) were synthesized under Mannich reaction conditions. Out of twenty compounds, around six derivatives were selected for evaluation of antihypertensive activities by a non-invasive method using the Tail Cuff method. Most of the compounds showed good antihypertensive activity. Few compounds like vj3, vj6, vj9, vj14, vj19, and vj20 were found to show a highly...
Read More
