Posted by admin on Oct 31, 2021 in |
In the present study, an effort has been made to estimate Rasagiline and Riluzole simultaneously in their bulk and physical mixture by UV-Visible spectrophotometric methods. The methods developed are precise, reliable simultaneous equations and area under the curve (AUC) method. The absorption maxima in the simultaneous equation method are 265.20 nm and 263.40 nm, respectively, for rasagiline and riluzole. Similarly, in the area under the curve method, the wavelength selected for estimation is in the range of 260.20 – 270.20 nm and 258.40-268.40 nm, respectively for rasagiline and riluzole. In the two methods developed, the Beer- Lambartz’s range was in the concentration range of 50 to 250 µg/mL for rasagiline and 4 to 20µg/mL for riluzole. The percentage recovery was found to be in the range of 100.43% and 100.01% for rasagiline and riluzole. ICH guidelines were followed in the proposed methods for their reproducibility and accuracy. The proposed methods can be adopted industrially and in research laboratories for the routine simultaneous analysis of Rasagaline and Riluzole in their...
Read More
Posted by admin on Oct 31, 2021 in |
In this study, a new simple, rapid and accurate, sensitive isocratic method was developed for the simultaneous determination of the Anti-retroviral drugs in pharmaceutical dosage forms. The chromatography was run through Denali C18 column (150 x 4.6 mm and 5 µm particle size). Mobile phase containing mixer of buffer 0.1% OPA (PH.4.6) acetonitrile is taken in the ratio 40:60 was pumped through column at a flow rate of 0.8ml/min and isocratic elution with a total runtime of 7 minutes. The mixer of the buffer used in this method was 0.1% OPA. The temperature was maintained at 20 °C to 30 °C, optimised wavelength selected was 258 nm. The retention time of the lamivudine and Efavirenz were found to be 2.131 min and 3.058 min as respectively. The drug was stressed under alkaline (acid, base); oxidative, thermal, photolytic degradation was analysed. The validated method was developed as per ICH Guidelines. The accuracy, linearity, precision, robustness, LOD and LOQ was within the acceptable limits. Hence, this RP-HPLC method was stability-indicating can...
Read More
Posted by admin on Oct 31, 2021 in |
Diabetes mellitus is one of the familiar metabolic disorders affecting the global population. In the modern system of medicine, there are still no satisfactory promising agents available for the effective management and treatment of diabetes. The current study aimed to investigate the in-vitro antioxidant and antidiabetic potential of the combination of s-allyl cysteine (a phytochemical) and taurine (an endogenous biomolecule). Despite numerous pharmacotherapeutic properties of s-allyl cysteine (SAC) and taurine (TAU), their combined in-vitro effects as antidiabetic and antioxidant had not been explored, and scientific data were also lacking to be exposed as yet. The combination (SAC/TAU) gives in-vitro antioxidant activity when subjected to the tests like reducing power, hydrogen peroxide & DPPH radical scavenging assays and in-vitro antidiabetic activity when subjected to the tests like α-glucosidase & α-amylase inhibitory activities. The IC50 value were reducing power test (significant with the ascorbic acid), hydrogen peroxide radical scavenging test (4.84 µg/ml), DPPH assay (16.30 µg/ml), α-amylase inhibitory activity test (17.26 µg/ml), and α-glucosidase inhibitory activity test (5.73 µg/ml). Hence, the...
Read More
Posted by admin on Oct 31, 2021 in |
Oral cancer is one of the lethal cancers, having first rank in India and sixth most deadly cancer in world and most of the time occurs due to improper lifestyle and adverse habits. Cancers of the lung, oral cavity, pharynx, larynx, esophagus, urinary bladder, renal, pelvic and pancreas are among the neoplastic diseases induced by smoking. Epidemiological studies have firmly identified the connection between smoking and oral cancer. In the review, we have discussed about the risk factor of oral cancer, recent advancement in treatment of oral cancer and cases in Karnataka state of India. We focused on the reason of oral cancer, as many studies suggested that tobacco (smokeless and smoking), excessive consumption of alcohol, and exposure of radiation are the main causing agents of oral cancer. People adopted tobacco socially in India and there is something to worry about that people are not aware that tobacco is primary causal factor of oral cancer. In present study, we focused on the treatment of oral cancer and what modification...
Read More
Posted by admin on Oct 31, 2021 in |
Mother nature has gifted with many herbs that have been found to have various pharmacological and therapeutic activities. One among them is the Rose plant which is available everywhere easily and has been used for ages. There are at least 200 species of rose flowers, amongst them Rosa damascena Mill. species is widely utilized in many industries for different purposes. Rosa damascena well-known as Rose, king of flowers, also known for its sweet smell and beauty, has numerous pharmacological properties, including antioxidant, antidiabetic, antitussive, anti-inflammatory, relaxant effect on tracheal chains, hypnotic, antibacterial, and anti-HIV. The petals, hips, stems, leaves and roots of rose plants have medicinal values and contain various secondary metabolites, including vitamins and minerals. Extracts from different parts of the rose plant have also been reported to show antibacterial and anti-fungal activity. Rosa damascena is cultivated and produced in Bulgaria, some regions of Turkey, and Tunisia, China, and India. This article is a comprehensive review of the traditional and pharmacological uses of Rosa...
Read More
