Posted by admin on Sep 30, 2021 in |
The present study was to evaluate Hepatoprotective activity of aqueous extract of Hyptis suaveolens whole plant (AEHS) against Sodium arsenite (2.5 mg/kg) induced hepatotoxicity in Wistar rats for a period of 28 days. Rats were divided into five groups, each with 6 rats. Except for group I, all remaining groups was served with Sodium arsenite oral administration to induce hepatotoxicity prior to standard and plant extract administration. Group II served as sodium arsenite treated group (toxin), group III served with Vitamin-E, standard (Hepatoprotective drug) Group IV and Group V Experimental rats received AEHS orally at the doses of 250 mg/kg and 500 mg/kg daily for 28 days. Hepatoprotective effects were investigated by assessment of serum biochemical enzymes such as alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) total bilirubin (TB), malondialdehyde (MDA), and antioxidant enzymes (SOD, CAT, GPx and GSH), along with histopathological studies. There is a significant decrease in the levels of AST, ALT, ALP and TB and an increase in the Catalase, GSH, GR and GPx...
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Posted by admin on Sep 30, 2021 in |
In recent years, the nasal route is gaining increasing importance for systemic administration of drugs and targeting to brain. The drug delivery to the brain is limited due to several factors, including presence of blood-brain barrier, enzymatic degradation, and efflux of drug by P-glycoprotein. Nasal route is employed to target the brain using various direct pathways via nasal mucosa and to bypass blood-brain barrier. The nasal route has limitations like small surface area, possibility of nasal irritation, and low volumes of administration. Various strategies have been employed in order to enhance nasal absorption and drug uptake in the brain. Nanotechnology-based formulations is one of the most investigated approaches in recent years for effective brain targeting. Lipid-based nanocarriers serve as a promising strategy owing to their ability to facilitate drug permeation through the nasal mucosa and reduce drug efflux by the blood-brain barrier by inhibiting efflux transporters. This review summarizes nose to brain drug transport pathways, mechanism of nasal absorption, various strategies used to improve nasal absorption, and a detailed...
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Posted by admin on Sep 30, 2021 in |
Orodispersible tablet technology allows tablets to be administered without the need for additional water, which would increase pediatric patient compliance. In this paper, an orodispersible paracetamol tablet formulation with flavor masking technology was developed. For this purpose, the methacrylic acid-derived polymer, Eudragit® E100, has the ability to form films on particles, which are insoluble at pH higher than 5.0 and soluble lower than it. The coated granules were obtained by coating the paracetamol with the Eudragit® E100 polymer (20% w/w) in Hüttlin Oystar fluidized bed. The tablets were obtained by direct compression with 800 mg as average weight, and the formulations were differentiated by the used disintegrant: Pharmaburst® 500, Prosolv® ODT G2 or Starlac®. Characterization of the granules and afterward of the obtained tablets were carried out. All formulations reached average weight, hardness, friability, disintegration in accordance with the proposed specifications. The mean disintegration time of the tablets was 20 seconds. Taste masking was evaluated in-vitro from a dissolution method adapted from the 41st United States Pharmacopeia, where the...
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Posted by admin on Sep 30, 2021 in |
Diabetes Mellitus increases the risk of both microvascular and macrovascular complications, out of which CVD affects approximately 32.2% of people with Type 2 Diabetes Mellitus globally. It is predicted that for every 1% increase in HbA1c is associated with a 30% increase in all-cause mortality and a 40% increase in CVD mortality in T2DM patients. This study aims to evaluate the correlation of HbA1c% with various hematological indices and to elucidate the possible changes in some hematological and lipid parameters in people with poor glucoregulation. A total of 76 patients of both gender with type 2 DM were included in the study after fulfilling the exclusion and inclusion criteria. Data from complete blood picture reports of the subjects were collected and documented. The collected data includes the values of HbA1c, some elements of complete blood picture, and lipid profile. The subjects were divided into two categories with HbA1c% ≤ 7 and HbA1c% > 7. All blood parameters under study except lymphocytes showed a significant mean increase in subjects with HbA1c%...
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Posted by admin on Sep 30, 2021 in |
Anxiety and Depression is the most prominent and crippled Neuropsychiatric Disease. World Health Organization (WHO) reported is the most burdensome disease of society. We therefore aimed at evaluating the Anti-Anxiety and Anti-depressant potential using Achyranthes bidentata Blume (Chinese name Huainiuxi). This study compared Leaves and Root part of Achyranthes bidentata methanolic extract (ABME) on standardized mouse models of Anxiety and depression. The dried Leaves and Root was macerated with methanol separately and administrated and discern the dose of 100 mgk g-1 p.o. and 200 mgkg-1 p.o. of Achyranthes bidentata methanolic extract of Leaves (ABMEL) and the dose of 100 mgkg-1 p.o and 200 mgkg-1 p.o. of Achyranthes bidentata methanolic extract of Root (ABMER) were employed in Elevated Plus Maze test (EPM) and Open field test (OFT) with 1 mgkg-1 i.p of Diazepam as a standard drug to assess the anxiolytic activity and Modified Forced Swim test (MFST) and Tail suspension test (TST) with 15 mgkg-1 i.p. of Imipramine as a standard drug to assess the anti-depressant activity in Swiss...
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