Posted by admin on Jun 30, 2021 in |
Bacterial infections are one of the prominent causes of health problems and mortalities around the world. Medicinal plants are a rich source of antimicrobial agents and provide a safer and cost-effective way of treating bacterial infections. The objective of the present investigation was to evaluate the anti-bacterial potential of petroleum ether and methanol extracts of Anacardium occidentale L. leaf. The anti-bacterial potential of A. occidentale L. leaf was tested against gastrointestinal tract infection-causing bacteria such as Escherichia coli, Shigella flexneri, Enterococcus faecalis, Vibrio cholariae, Staphylococcus aureus, Klebsiella pneumoniae, and Salmonella typhi by using the agar well diffusion method. Streptomycin was taken as the reference antibiotic. The results indicated that petroleum ether extract of A. occidentale L. exhibited the highest zone of inhibition against Shigella flexneri (26±0.75) and least against Staphylococcus aureus (11±1.32). In contrast, methanolic extract exhibited the highest zone of inhibition on Vibrio cholariae (20±1.41) and least against Escherichia coli (11±0.21). The preliminary phytochemical analysis revealed the presence of alkaloids, glycosides, tannins and polyphenolic compounds, flavonoids, saponins, steroids,...
Read More
Posted by admin on Jun 30, 2021 in |
COVID-19 has been proved to create a pandemic over the world within a few years. All scientists and health workers are trying to develop an effective treatment with collaboration. Various strategies such as antiviral, antibacterial, and antimalarial drugs have been employed to treat COVID- 19, but they were found to relieve the symptoms only. The formation of various variants of the virus in various global parts made the treatment of COVID-19 more difficult. Developing an effective vaccine is the main goal of clinicians and scientists, which is under clinical trials, and some vaccines which have been approved for the treatment such as COVAXIN, COVISHIELD, ASTRA Zenaca, and SPUTNIK V vaccines are being used to develop antibodies against COVID-19, but due to spread of variants of virus these vaccines are not supposed to be 100 percent protective against the virus. With the help of nanotechnology, the treatment of SARS- CoV-2 can be made efficient due to its direct target on viral cells and modifying its genetic material functionings. In this...
Read More
Posted by admin on Jun 30, 2021 in |
Carbohydrate-based therapeutics are extremely potent, and many carbohydrate-based drugs are in the stage of preclinical or clinical trials. There is a growing interest in developing carbohydrate analogues for novel drug discovery as most of the recently used carbohydrate drugs display significant pharmacological activities and low toxicity. Also, the search for an antipyretic drug is a never-ending challenge. This research aimed at the development and synthesis of a series of amide-linked sugars (PV1-PV20) by coupling brominated sugars with varying amino acids coupled with nicotinic acid (GP1-GP10). Characterization of the derivatives synthesized was done by Infrared and Nuclear Magnetic Resonance Spectroscopy. These congeners were tested to analyze their antipyretic potential, and eight analogs out of twenty showed significant antipyretic activity. Thus, the carbohydrate-based amide derivatives show important action in obstruction and therapy of fever. Further work on these lines may play an important role in maintaining good health at a low...
Read More
Posted by admin on Jun 30, 2021 in |
Genus Curcuma L. ( Zingiberaceae), comprising of 120 species, is distributed throughout South and South-East Asia, with few species extending to China, Australia, and South Pacific. Four species of Curcuma are reported from Melghat. Of these C. longa L. is cultivated while C. inodora Blatt., C. pseudomontana J. Graham and C. decipiens are wild. C. decipiens being rare could not be collected. Curcuma inodora Blatt. Known as ‘Jangali Halad’ is a common herb of Melghat at higher elevations. In the Melghat area, populations of C. inodora are found to show many distinct variations in aerial as well as underground characters. Twelve distinct variants of C. inodora and C. pseudomontana and C. longa were collected. HPTLC screening of free amino acids showed the presence of four to eleven amino acids in Curcuma inodora accessions, while in C. pseudomontana and C. longa, ten amino acids each were found. Glycine and Proline were found in all samples studied. Amino acid composition is specific for each species and variants; hence can be used...
Read More
Posted by admin on Jun 30, 2021 in |
Inflammation is a chemical-mediated defense mechanism of body. Inflammatory process is also associated with development of various diseases like rheumatoid arthritis, psoriasis, atherosclerosis, and diabetes. Diabetes mellitus is a most common and life-threatening health problem in today’s date. Several marketed anti-diabetic drugs are characterized with side effects. Hence there is a need to search a safe and effective anti-diabetic drug. In that regard, the present study was carried out to ascertain phytochemical constituents and to evaluate the anti-inflammatory and anti-diabetic effect of an Indian traditional medicinal plant, Holarrhena pubescens (seed). The dried and powdered seeds of H. pubescens was extracted by ethanol and then fractionated successively. These fractions were evaluated further for anti-inflammatory activity by in vivo models for acute and chronic inflammation. The anti-diabetic activity of plant materials was evaluated by oral glucose tolerance test and blood sugar estimation in streptozotocin-induced diabetic rat model. The results of the present study illustrated that the petroleum ether fraction (HPPT) of the plant material at 400 mg/kg dose showed the most...
Read More
