Posted by admin on Jun 30, 2021 in |
Postoperative atrial fibrillation (POAF) is a frequent rhythm disturbance after cardiac surgery and is associated with poor cardiovascular outcomes. Beta-blocker therapy is an effective strategy to prevent or decrease the high incidence of POAF and β1-adrenergic receptor (β1AR) polymorphisms that affect the cardiac response to β1AR antagonists. The study objective is to analyze the association between genetic variations in the β1AR gene and the risk of POAF and the prophylactic effect of beta-blockers. Totally, 198 patients undergoing first-time cardiac surgery were examined. The patients after operation were grouped as either with POAF or without POAF according to their continuously electrocardiogram monitoring within ICU and hospital admission period. Subsequently, genotype frequencies of the β1AR gene were determined by polymerase chain reaction-restriction fragment length polymorphism. The results showed that 63 patients (31.8%) of the total study population developed POAF. After the application of a multivariate logistic regression model, the incidence of POAF was associated with Arg389Gly genotype (OR=2.48; 95% CI, 1.06-5.76; p=0.036), Arg389Arg genotype (OR=3.38; 95% CI, 1.28-9.33; p=0.018) and Arg389Ser49...
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Posted by admin on Jun 30, 2021 in |
Inflammatory bowel diseases (IBD) are chronic and relapsing intestinal inflammatory conditions, hallmarked by a disturbance in the bidirectional interaction between gut and brain. IBD is Ulcerative colitis (UC) and Crohn‘s disease (CD). Conventional therapies are inadequate and are associated with several systemic side effects due to lack to localization of active moiety at the inflamed site. Treatment option range from small molecules to macromolecules (peptides, proteins and oligonucleotides) that target multiple therapeutic pathways, and dosed via injectable, oral or the rectal route for local bowel treatment. Conventional therapies are inadequate and are associated with several systemic side effects due to a lack of localization of active moiety at the inflamed site. But colonic drug targeting is a novel, potentially active area of research intended and focused on drug delivery for treating localized disease. Targeted drug delivery to the colon would ensure direct treatment at the disease site, lower dosing, and fewer systemic side...
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Posted by admin on Jun 30, 2021 in |
Fluvoxamine Maleate, an oral serotonin reuptake inhibitor, has been used widely for the treatment of anxiety. Sustained-release matrix-type drug delivery system has advantages over conventional modes of drug administration, enhancing drug bioavailability as it avoids the first-pass metabolism and improves patient compliance. Optimization of the formulation was performed by varying the concentration of natural polymer Moringa oleifera gum and HPMC K100, i.e., releases retarding polymers. Sustain release matrix tablets were formulated, and the drug release profiles of formulations F3 and F6 were found to be 93.8008% and 96.94108%,...
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Posted by admin on Jun 30, 2021 in |
Sarcoidosis is a rare autoimmune inflammatory disease, which is difficult to diagnose due to a lack of approved clinical tests. It has been observed in each race, and highest among the Scandinavia, African-American but Asians are less vulnerable to it. It affects most prominently adults from the age group of 20 to 60. The main characterized symptom of this disease is non-caseating granulomas, specifically in the lungs and lymph nodes progressing to lungs impairment to pass oxygen, and finally total failure of lungs as well as heart. The main cause of sarcoidosis is immune irregularities in genetically predisposed individuals which manifests antigen(s) like microorganism or their products, due to an ex-aggregated immune response. There is no specific treatment available, although corticosteroids help in disappearing its symptoms. While more than 50 percent of the patients don’t require any treatment and illness goes on its own, only 10% require treatment in which severe symptoms developed and last long. The current review enlightens the pathogenesis of the disease, clinical indications, diagnostic evaluation,...
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Posted by admin on Jun 30, 2021 in |
The present study was proposed to develop a simple, rapid, and economical UHPLC method was described for the method development, validation and forced degradation for the simultaneous estimation of glycopyrrolate and formoterol fumarate in bulk drug. The chromatographic conditions were observed in the column using Zorbax RXC18 (150 × 4.6 mm) 5 µm using a mobile phase composition of Water: Acetonitrile: Methanol (20:30:50 v/v) and pH was adjusted to 3.0 with dilute orthophosphoric acid. The flow rate was 1.0 ml/min, and the analytes were recorded at 279 nm. The Retention time (RT) was observed in 1.208 for Glycopyrrolate and 5.897 for Formoterol fumarate. A calibration curve was linear with a coefficient correlation between 0.999 to 1.0 over a concentration range of 20-60µg/ml for glycopyrrolate and formoterol fumarate. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.003,0.011µg/ml for Glycopyrrolate and 0.108,0.32µg/ml for formoterol fumarate. All the validation parameters were within the acceptance range according to ICH norms. The validation and forced degradation study was...
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