Posted by admin on Jun 30, 2021 in |
The demand for herbal medicines is growing at a drastic rate due to their improved pharmacological actions, minimal side effects, and cost-effectiveness. The ever-increasing cost of chemotherapy ruined the economic stability of many families. This led to the discovery of herbal medicines for cancer treatment. Tribes of Western Ghats have been using the roots of Apama siliquosa for cytotoxic activity. The methanolic and aqueous root extracts of Apama siliquosa Lamk were used to prepare different concentrations. These different dilutions of extract were used to carry out brine shrimp lethality assay & the LC50 value was determined. Cell line study by MTT assay using cancerous cell line (MCF7 cells-human breast adenocarcinoma cells) & LC50 value was determined. GCMS study on plant extract was carried out. The methanolic extract shows the presence of Caryophyllene oxide (m/z 220) methyl ester of Aristolochic acid I (m/z 355), Aristolactam I (m/z 295). Aristo lactam II (m/z 265), and Aristo lactam III (m/z 281). The aqueous extract shows the presence of Aristo lactam I (m/z...
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Posted by admin on May 31, 2021 in |
Biotransformation is a biological process in which the microbes are converting one form of compound to the another form. In the present research work, we studied about the conversion of Quercetinto kaempferol, which is having more therapeutic potential. Flavonoids are diverse group of secondary metabolites found especially in all plants. Flavonoids have Anti-carcinogenic, Anti-inflammatory, antioxidant, and Anti-allergic properties. Our study Quercetinis transforming into Kaempferol by Aspergillus niger (Allium cepa) through fermentation process at 37 ºC, PH 6 under aerobic conditions. The Transformed product (150 mg flavones / 200 ml medium) was extracted and analyzed by the spectral analysis (UV, IR, H-NMR, C-NMR) and mass spectrometry analysis process. The trans-formed product has more therapeutic potential in the treatment of wide range of cancer like breast, ovarian, gastric, pancreatic, lung...
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Posted by admin on May 31, 2021 in |
The main objective of this study was to Assessment of the acute toxicity of ethanolic extract of Polyherbal formulation in Swiss albino mice. In this study, the acute oral toxicity study of ethanolic extract of PHF1 was carried out according to Organization for Economic Co-operation and Development (OECD) guideline 423 and 407 on Swiss albino mice (20–30 g). In the study, the oral dose of 2000 mg/kg of PHF1 extract was administered in the treated group. General behavior, morbidity, and mortality were determined up to 72 h and compared to control group. Further animals were investigated for a period of 3days assess any other toxic effect. Behavioral changes and other parameters such as body weight, hematological parameters, and biochemical parameters were evaluated and compared to the normal group. The result of the study was mentioned that In acute toxicity study, treatment groups revealed neither morbidity nor mortality or any significant changes in behavior only drowsiness, sedation, and lethargy were observe in the group having 2000 mg/kg of Polyherbal formulations...
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Posted by admin on May 31, 2021 in |
The focus of the current article is to prepare the chrono-modulated dual release formulation using various optimization techniques. The conventional formulations as the Controlled Release Drug Delivery System (CRDDS) are not effective in the chronomodulated formulation. The advancement in research and development in CRDDS leads to the formulation of chronomodulated formulations. Dual release tablets are those in which two drugs are given in a single tablet in different layer as to avoid the incompatibility problem or single drug is given in two different layers as maintenance dose and loading dose. The formulation is fruitful in various diseases such as diabetes, arthritis, asthma, etc., and provides compliance to the patient as a patient has no need to wake up during night hours to take the mediation. The Quality by Design (QbD) techniques is used to make the formulation as much as safe and efficacious. By applying the QbD, product variability is reduced and leads to quality improvement, risk reduction, and production enhancement. In conclusion, chronomodulated drug delivery system using QbD...
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Posted by admin on May 31, 2021 in |
Congenital Hypothyroidism may be defined as a heterogeneous group of disorders characterized by goiter or cretinism due to an absolute or relative deficit of the enzyme Thyroid Peroxidase (TPO), and it is action. Chronic hypothyroidism also leads to goiter and cretinism associated with end gland damage, dysfunction, cancer, and failure, including the retina, kidney, nervous system, heart, and vascular tissue damage. The screening for Congenital Hypothyroidism (CH) may either be in the form of a thyroid function test or via thyroid peroxidase antibodies test, as recently recommended by the Thyroid Federation Association (TFA). Unto now, the treatment of goiter and cretinism is levothyroxine supplement and gland surgery removal. This review will establish the effectiveness of the enzymatic drug (TPO) and its indication for the treatment of PCH when compared to other therapies. This review also highlights the enzyme thyroid peroxidase (TPO) role and current treatment strategies on Congenital Hypothyroidism...
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