Posted by admin on Nov 30, 2021 in |
The purpose of the present investigation is to evaluate the applicability of hupu gum and lannea gum in the design of buccoadhesive patches for extended-release over a period of 6 hours, using Salbutamol sulphate as a model drug. The efficiency of these polymers was compared with already established synthetic polymer PEO coagulant. The patches were prepared by using the solvent casting method in which, initially backing layer with cellulose acetate was formed on which patches were cast for unidirectional drug release to buccal mucosa. In-vitro drug diffusion studies were done by using Franz diffusion cells. The kinetics of both the phases were calculated, and both the phases followed zero-order for the majority of the patches. Based on the swelling Index (%), buccoadhesive strength, ex vivo residence time and in vitro diffusion studies SHG9 (hupu gum), SLG9 (lannea gum) and SPEO6 were considered as optimized formulations as they could extend the drug release over a period of 6 hours as contemplated. Among three optimized patches, SHG9 and SLG9 were found...
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Posted by admin on Nov 30, 2021 in |
Indigenous plants like Withania coagulans fruits. Alstonia scholaris bark and Aegle marmelose leaves have been used for diabetes management by traditional Indian people for a long time. The present study was carried out to investigate anti-hyperglycemic potential of an herbal mixture comprising of extracts of these three plants in streptozotocin-induced diabetes in Wistar rats and to focus on its possible mechanism of action. Experimental diabetes was induced in Wistar rats by a single intraperitoneal injection of streptozotocin (65 mg/kg). Animals were divided in five groups (n=6) and treated with herbal mixture (100 & 200 mg/kg) for 4 weeks. At the end of the study period, fasting blood glucose, oral glucose tolerance, glycol-sylated hemoglobin, serum insulin, glucose uptake from rat hemidiaphragms, and liver glycogen were determined. Antioxidant enzymes of the liver, including superoxide dismutase and catalase, were evaluated. Histopathology of the pancreas was studied. The results of our study demonstrate anti-hyper-glycemic and antioxidant potential of the herbal mixture, justifying its use in the indigenous system of...
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Posted by admin on Nov 30, 2021 in |
Background: The present work aimed to evaluate the sustained release antipsychotic activity of formulated biodegradable mucoadhesive guar gum microspheres of atypical antipsychotic drug Olanzapine (OLZ) for intranasal delivery and to reduce the dose-related side effects of the drug olanzapine. Guar gum microspheres of Olanzapine were fabricated and designed by O/W emulsion solvent evaporation technique using non-halogenated solvents and PVA and tween-80 as surfactant and stabilizer. The prepared guar gum microspheres were characterized for various physical and micrometric properties. Box Behnken design of experiment was applied for the formulation of various batches. An optimized batch was selected for in-vivo studies. Objective: This study solely emphasizes on sustained effect of formulated Olanzapine microsphere on different symptoms of schizophrenia. Material and Methods: Rats of Charles foster strain were subjected to a battery of various behavioral tests for representing positive, negative, and cognitive impairment symptoms found in schizophrenic patients. Different tests performed were open field exploratory, elevated plus maze, forced swim, passive avoidance and Morris water maze. Results and Conclusion: During in-vivo studies,...
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Posted by admin on Nov 30, 2021 in |
Nanotechnology has gained a lot of importance and application in agriculture in the last decade. The present work was focused on the synthesis and characterization of magnesium oxide nanoparticles and on studying the effect of these nanoparticles on wheat (PBW-677 variety). Magnesium oxide nanoparticles were synthesized by chemical synthesis method and were characterised by using UV- Visible spectrophotometer. The seeds were treated with different concentrations (200 ppm, 500 ppm, and 1000 ppm) of nanoparticles. A Control group was also run along with in which the seeds were treated with tap water. The aim of the study was to see the effect of these nanoparticles on various parameters that include seed germination, estimation of chlorophyll content, and antioxidants. The present study showed that magnesium oxide nanoparticles increase seed germination, growth, phenolics, flavonoids, total antioxidants, chlorophyll and carotene and protein content of PBW-677...
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Posted by admin on Nov 30, 2021 in |
Isolation, identification, culturing, and chemical screening of a marine-associated bacterial strain, S6.2, were performed in this study. Anti-MRSA analysis of its extract was also conducted. Strain S6.2 was isolated from an unidentified red marine sponge and identified as Zooshikella kangwensis by 16S rDNA sequencing and biochemical characterization. On marine agar, the colonies embedded in the media and were pinkish and circular with oily smooth skin. Maximum growth was observed at 78 h (200 cfu/ml) and minimum growth at 168 h (23 cfu/ml).The purified bacteria were cultured in marine broth; cell density started to increase after 3 h and proceeded to the lag, exponential, stationary and dead phases at 24, 30, 78, and 132 h, respectively. Based on LCMS/MS analysis, strain S6.2 produced pinkish pigments: prodigiosin and two prodigiosin derivatives, namely 2-methyl-hexyl-prodiginine and 2-methyl-3-propyl-prodiginine. Anti-MRSA activity deduced by thin-layer chromatography (TLC) direct bioautography revealed that the active constituents contained in an ethyl acetate extract were nonpolar compounds. The MIC values varied between 12.5 and 25.0 µg/ml, while the MBC value...
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