Posted by admin on Jul 31, 2022 in |
The extracellular L-Asparaginase is an amidase group enzyme. In recent years enzymes gained greater importance in clinical research. The enzyme’s capability to convert L-Asparagine into Aspartic acid and ammonia is the motivation after its anti-cancer action. ALL is a type of hematologic cancer that mainly affects children at the age of 2 to 10 years. L-asparaginase is a basic constituent of ALL and Hodgkin’s lymphoma treatment. Because its foreword into pediatric treatment procedures in the 1960s, continued existence rates in children have steadily increased to almost 90%. Juvenile and adolescent patients diagnosed with ALL at the age group of 15-39 years have historically had poorer outcomes. Different diagnostic methods are available for ALL like blood tests, Bone marrow tests, Imaging tests and Spinal fluid tests. Apart from its medical applications, it is broadly used in the food industry to engage in acrylamide, a probable human carcinogen, and production in carbohydrate-rich foods cooked at high temperatures. L-Asparaginase plays an important role in the biosynthesis of the aspartic family of amino...
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Posted by admin on Jul 31, 2022 in |
Natural products with medicinal value are becoming increasingly important in food preservation. Tinospora cordifolia, a plant commonly known as Guduchi, is highly beneficial in the medicinal field and has been used for centuries to treat various diseases. Due to the discovery of active components in Tinospora species and their potential for disease control, this plant has gained interest across the globe. Various pharmacological characteristics such as antioxidant, hepatoprotective, neuroprotective, antidiabetic and analgesic antitumor activities support its medicinal properties making it a promising herb with various health benefits. These biological activities of Tinospora species can be attributed due to the presence of a wide range of phytoconstituents, including alkaloids, flavonoids, lignans, Furano diterpene glucosides and sterols. The clinical importance of Tinospora cordifolia is included in this review to investigate its potential uses as an ingredient for the food industry. The future scope of the review remains in exploiting and isolating antimicrobial compounds to enable new and effective formulations in food...
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Posted by admin on Jul 31, 2022 in |
Floating drug delivery systems can increase the gastric retention time by manufacturing the systems with a density less than the gastric contents of the stomach. This causes the system to float over the gastric contents in the stomach without affecting the gastric emptying rate for a prolonged period. Glimepiride was selected as a model drug to increase oral bioavailability and efficacy. Hydroxypropyl methylcellulose (HPMC) and Carbopol, which are hydrophilic swellable polymers, govern the drug release from the prepared floating tablets. Buoyancy was achieved by using sodium bicarbonate as a gas-generating agent. The optimized formulation F5 showed a drug release of 42.14% within 12 hrs, whereas the floating lag time was found to be 50 seconds. The formulation variations were made in HPMC and Carbopol concentrations. The dissolution study revealed that sustain release profile can be achieved by increasing polymers concentrations in the formulation. The current study confirms that HPMC and Carbopol with sodium bicarbonate as a gas generating agent can develop floating systems that can provide controlled drug release for...
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Posted by admin on Jul 31, 2022 in |
Present study reported a simple, rapid, eco-friendly and economical method for efficient production of AgNPs utilizing Manilkara zapota (M. zapota) extract. UV-Vis spectroscopic analysis was employedto ascertain the formation and stability of the synthesized AgNPs. The AgNPs were further characterized using TEM (Transmission Electron Microscopy), DLS, FT-IR, and XRD. The AgNPs exhibited a clear SPR band around 420 nm and were stable upto 6 months as confirmed during UV-Vis spectroscopic analysis. The nanoparticles were spherical in shape with a 10-15 nm size range, as evidenced by TEM results. FT-IR spectral studies demonstrated the presence of biomolecules such as phenols, amino acids, carboxylic acids, and aldehyde in the fruit extract, which might be responsible as reducing and capping agents during the formation of nanoparticles. From the DLS studies, the particles were found to have an average diameter of 90.28 nm, zeta potential value of -24.8 mV, and polydispersity index (PDI) of 0.147. The intense XRD pattern clearly revealed the face center cubic (FCC) structure as crystalline silver. The AgNPs efficiently...
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Posted by admin on Jul 31, 2022 in |
Infectious diseases are the most significant cause of fatalities worldwide. Staphylococcus aureus could be a common human infective microorganism that will trigger various infectious diseases, like soft tissue and skin infections, osteomyelitis, bacteremia, endocarditis, and fatal respiratory illnesses. In recent decades, because of the evolution of microorganisms and the abuse of antibiotics, the drug resistance of S. aureus has been stepped by step exaggerated, and the infection rate has risen worldwide. Accumulating proof has demonstrated that the resistance mechanisms of S. aureus are complicated, that is, resistant to several types of antibiotics. Multiple antibiotic-resistant Staphylococcus aureus is one of the common causes of severe nosocomial infections, and the gastrointestinal tract is an important source of its transmission. Productive treatment remains difficult and needs the analysis of each novel anti-microbial and connected aspect of care, like communicable disease consultation, diagnostic technique and supply source. This review focuses on developing resistance to currently used antibiotics and examines prospects for new antibiotics and the known use of drug...
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