Posted by admin on Jun 30, 2022 in |
Introduction: Skin and subcutaneous tissue adverse drug reactions (ADR) are among the most common types of Cutaneous Reaction. The incidence rate of Cutaneous ADR is 1-3% for admitted patients in developed countries, whereas, in developing countries, it is 2-5% for admitted patients. Aims & Objective: To analyze the patient demographics, characteristics of the reaction, type of reaction, seriousness of the reaction, classification of the drugs involved, action is taken and outcome of reactions, causality assessment, severity assessment, and preventability of cutaneous ADRs. Material and Methods: The ADR monitoring center reported all cutaneous adverse drug reactions between September 2017 to June 2020 (34 months). All reported ADRs were clinically verified by committee members and retrospectively analyzed using various parameters such as type of reaction, causality assessment, drug preventability, and severity. Results: Out of 990 ADRs reported during the study period, 232 (23.43%) were cutaneous ADRs concerning 204 patients, including indoor and outdoor patients. A maximum number (48.7%) of ADRs were reported in the adult age group between 20-44 years. The majority...
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Posted by admin on Jun 30, 2022 in |
In present era research work has the continuous focus on the formulation development of chitosan-coated flexible liposomes of Mupirocin that has persistent mitigation of laceration. Skin injuries (laceration), an important health problem that needs to be managed properly in order to avoid serious consequences. The current focus in wound therapy is on upholding the moisture balance in the wound bed and protection against pathogenic invasion. Wound dressings in a form of flexible liposomes incorporating antibiotic mupirocin, can be applied to control dermal infections and thereby ensure optimal wound healing. Drug in flexible liposome provides prolonged contact between drug and wounded area, reducing the need for frequent application of wound dressing. Our project aims to develop the chitosan-coated flexible liposomes of Mupirocin in a soya lecithin and edge activators. The drug Mupirocin was analysed through various physio-chemical and analytical parameters like pre-formulation studies, melting point, solubility, calibration curve, FTIR and drug excipient compatibility study. The chitosan-coated flexible liposomes which were prepared by Rota evaporator technique and incorporation into flexible liposomes...
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Posted by admin on Jun 30, 2022 in |
In the present research work, a new UV spectroscopic and RP-HPLC method was described for simultaneous estimation of Aceclofenac (ACL) and Pantoprazole (PNT). Simultaneous Equation method was applied for the spectrophotometric determination of ACL and PNT. Statistical calculations were done by use of 276 nm and 289 nm wavelengths. In RP-HPLC method, the estimation of ACL and PNT carried out by ACN: Buffer (Phosphate acetate) (80:20 v/v) as mobile phase, pH 6.8 at a flow rate of 1.0 mL/min and YMC Triart C18 column (250 mm × 4.6 mm, 5 µ), column. The detection of ACL and PNT was carried out at 295 nm. The retention time of ACL and PNT was found at 3.739 and 2.991, respectively. The results of analysis in both the methods were validated as per ICH guidelines in terms of linearity, range, accuracy, precision, LOD, LOQ, ruggedness, robustness, and solution stability; from this study, it was concluded that the developed method of RP-HPLC can be successfully used for the estimation of ACL and PNT...
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Posted by admin on Jun 30, 2022 in |
Artemisia annua L. is an herbaceous plant from which the antimalarial sesquiterpene lactone, Artemisinin, is obtained. In Ghana, Artemisinin-Combination therapies are used as first-line treatment for managing malaria. The present study, the first of its kind in Ghana, sought to carry out the preliminary morphological and phytochemical evaluation and investigate the artemisinin content of Artemisia annua planted in Ghana. Seeds of A. annua were planted, and the dimensions of the shoots of the germinated seedlings were taken from week one till maturity. Qualitative phytochemical analysis was performed on the powdered plant parts following standard techniques. The artemisinin contents of the leaves and stem were determined using Ultra-High-Performance Liquid Chromatography coupled with a triple Quadrupole Mass Spectrometry (UPLC-QqQ-MS) using Multiple Reaction Monitoring (MRM) modes. Morphological observation showed that the Ghanaian grown A. Annua attained an average height of 36.94 cm at maturity. The leaves are lobed and have a strong aromatic odour. The ethanol and petroleum ether extracts of leaves, stem and roots s tested positive for secondary metabolites such...
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Posted by admin on Jun 30, 2022 in |
Herbal plants have long been known to have antifungal properties. The medicinal plants are prospective in aquaculture as an alternative to antibiotics and other anti-candida drugs. This article aims to review the reported herbal medicines with their research findings that have an enormous future prospective for the effective treatment of Candida infections. Various species of Candida were classified and their pathogenesis and mechanism of action were highlighted. Mechanisms of action of commonly used synthetic anti-candida drugs were compared to that of the herbal plants. Recent plant-based antifungal activity studies were analyzed. Ten species of candida, namely Candida albicans, Candida glabrata, Candida parapsilosis, Candida krusei, Candida dubliniensis, Candida lusitaniae, Candida guilliermondii, Candida rugosa, Candida zeylanoides and Candida tropicalis were found to be responsible for infection in human. Plant-based natural products were found to produce anti-candida actions based ongermination inhibition and formation of biofilm, cell metabolism, cell wall integrity, cell membrane plasticity, and induction of apoptosis. Around 20 research works were analyzed, and it was found that the majority of the...
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