Posted by admin on May 31, 2022 in |
In any nation’s public health care system, plants play an essential role in therapeutic treatment. The plant Thevetia peruviana is an evergreen ornamental dicotyledonous shrub belonging to the family Apocynaceae. Thevetia peruviana is widely distributed in Central and South America and Asian countries, especially in India and Srilanka. Alkaloids, flavonoids, steroids, terpenoids, tannins, saponins, cardiac glycosides, and other secondary metabolites are found in Thevetia peruviana. All parts of these plants are toxic and contain a variety of cardiac glycosides, including neriifolin, thevetin A, thevetin B, and oleandrin. The leaves of the plant are used as a cardiotonic and diuretic and are also reported to possess medicinal value in traditional systems of medicine. Several studies reported pharmacological activity in various plant parts, including seeds, flowers, bark, fruits and leaves. The purpose of this review is to provide the complete data, including morphology, cultivation and propagation, distribution, phytochemistry, traditional uses & pharmacological...
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Posted by admin on May 31, 2022 in |
Drug-Related Problem (DRP) affects the hospital stay, healthcare budget, quality of life, morbidity, and mortality. The study aims to assess the prevalence and predictors of DRPs in hospitalized patients and provide intervention. A prospective interventional study was conducted in the in-patient medical department of the NGO hospital. A total of 310 subjects were enrolled and screened for the presence of DRP. The identified DRPs were categorized according to the Hepler and Strands. Depending on DRP, the clinical pharmacist provided an intervention at the patient and physician level and recorded the acceptance. The data was analyzed using SPSS™. Binary logistic regression was employed to associate risk factors with DRPs. The prevalence of DRPs in the medical department was 80.0%, with a 0.93 DRP/patient average. Drug interactions(DI) (28.4%) and adverse drug reactions (ADR) (21.8%) are the most common DRPs. Anti-microbials (78.0%) and Anticonvulsants (81.2%)showed a greater risk of developing DRPs. Variables like advanced age, the habit of alcohol and smoking, hospital stay, and polypharmacy were significantly associated with DRPs. A total...
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Posted by admin on May 31, 2022 in |
Hypothyroidism is a progressive disorder characterized by varying degrees of thyroid failure, metabolic consequences, and hemodynamic changes that decrease renal plasma flow and glomerular filtration rate, increasing serum creatinine level. Therefore, the present study aimed to evaluate and analyse the level of serum urea, creatinine and thyroid function tests in cases of subclinical hypothyroidism and apparently healthy controls and determine whether thyroid dysfunction has detrimental effects on serum creatinine and urea levels in subclinical hypothyroidism cases. Both thyroid function tests (TSH, T3, and T4), serum urea, and creatinine were analyzed in 45 cases with subclinical hypothyroidism and 45 healthy subjects. Patients with subclinical hypothyroidism had a statistically significant rise in creatinine levels compared to controls. In contrast, there was no significant difference in serum urea levels between patients and controls. There was likewise a positive correlation between creatinine and urea in patients with subclinical hypothyroidism. The study results indicate that renal function should be regularly monitored in patients with subclinical...
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Posted by admin on May 31, 2022 in |
Punica granatum (Pomegranate) external peel extract in 70% ethanol was challenged against two non-albicans Candida spp. to find out it’s possible antifungal effects in disc diffusion technique as well as in microtiter dilution to find out MIC levels. Although both showed sensitivity zones in disc diffusion technique at 100 mg/mL concentration of the extract, at lower concentrations (<16.6 mg/mL), only C. guilliermondii showed MIC value at 0.52 mg/mL, while C. tropicalis did not show any inhibition of growth at these concentrations of the...
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Posted by admin on May 31, 2022 in |
The present study aims to develop a verse phase HPLC method for the simultaneous estimation of Metformin and Saxagliptin. In bulk and pharmaceutical dosage form and to validate the proposed method in accordance with ICH guidelines for the intended analytical application. Multiple trials were run to Metformin and Saxagliptin, get eluted with good peak symmetric properties. Mobile phase Phosphate buffer: Methanol: Acetonitrile (40:5:55), Column Hypersil silica and flow rate 1.0ml, detection wavelength at 233nm, column temperature 300C and diluents Water: Methanol (50:50). Column Hypersil silica and flow rate 1.0 ml, detection wavelength at 210 nm conditions were finalized as an optimized method. This method was validated for Stability Data, System suitability, Precision, Linearity, Accuracy, Robustness, Ruggedness, LOD, and LOQ. System suitability parameters were studied by injecting the standard five times, and results were well under the acceptance criteria. Linearity study was carried out between 25% to 150% levels, r2 value found 0.999. By using the above method, assay of the marketed formulation was carried out 99.63% was present. So,...
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