Posted by admin on May 31, 2022 in |
Alcoholic peripheral neuropathy is a potentially incapacitating complication of long-term excessive consumption of alcohol characterized by pain and dysesthesias, primarily in the lower extremities. The neurological effects of ethanol consumption are complex, encompassing both the central and peripheral nervous systems. It breaks into acetaldehyde which impairs and destroys the majority of neuronal functions. As a result, signals become intensified from the injured neurons and the nearby surrounding neurons, resulting in a painful condition. The study aims to evaluate the different doses of Erythropoietin, i.e., 250U/kg and 500U/kg, in alcohol-induced peripheral neuropathy. The present study involved evaluating the neuroprotective activity of Epo in alcohol-induced PN in rats by assessing behavioral, biochemical and electrophysiological, liver function tests, parameters. This study concludes that the two doses of Epo improved sciatic nerve conduction, behavioral studies and antioxidant activity in sciatic nerve homogenate. Among the two different doses of Epo, 500U/kg was most effective besides showing neuroprotective properties against alcohol-induced...
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Posted by admin on May 31, 2022 in |
The medicinal plant Jasminum flexile is reported in traditional medicine as an antidiabetic and anti-inflammatory agent. There is no scientific report on the antibacterial and anti-inflammatory activity of extracts of Jasminum flexile. This study investigated the antibacterial and anti-inflammatory potential of the hydroethanol extract of leaves of Jasminum flexile, its column fractions and constituent compounds. The column fractions MF14, MF9 and MF5 expressed a zone of inhibition of 12 mm against Streptococcus mutans and the isolated compound JFLC1 showed a zone of inhibition of 10 mm against Streptococcus mutans, Escherichia coli, and Klebsiella pneumoniae comparable to that of the standards ampicillin, kanamycin and chloramphenicol respectively at the same concentration. The highest anti- inflammatory potential was found for the column fraction MF3 (55.14%) as assessed from the percentage of haemolysis. The results reveal that the isolated compounds and extracts of leaves of Jasminum flexile possess significant antimicrobial and anti-inflammatory...
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Posted by admin on May 31, 2022 in |
Aim of study: A Randomized controlled trial was planned to evaluate the Clinical efficacy of Nidigdhikadileha an Ayurveda multi-dimensional herb preparation in children suffering from Recurrent Respiratory tract infection in children. Nidigdhikadileha contains Nidigdhika (Solanum Xanthocarpum), Pippali (Piper longum), Amrita (Tinospora cardifolia), and Nagar (Zingiber officinale). All these drugs have been described to have anti-tussive and antimicrobial properties. Material & methods: A total of 90 children, including male and female children, were studied for complaining of Recurrent Upper Respiratory Tract infections and were registered and divided into 3 groups (Group A, B, C). In group A, children were administered Nidigdhikadileha, dose180-200 mg/kg/dose twice a day for 2 months in children suffering from RURTI. In group B, honey drops were administered to 30 children at a dose of 1ml/kg/day, and in Group C there is also 30 patients were administered Sitopaladi churna at a dose 100 mg/kg/day. All the treated cases were assessed at each follow-up on the 14th day, 28th day, 42nd day, and 56th day, and post-follow-up was...
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Posted by admin on May 31, 2022 in |
Urochloa distachya (Poaceae), commonly known as Signal grass 20-60 cm long found in tropical Asian origin, Africa, and other countries. Generally, it has been used in fodder, animal feed etc., and least and no therapeutic activities were reported. The present study was established to identify the phytochemicals by using GC-MS of the U. distachya leaves part. The leaves part of the plant was extracted in methanol by using the Soxhlet apparatus. The GC-MS Methanolic extract of U. distachya identified 26 phytocomponents; Z-7-Pentadecenol; t-Butyl hydrogen phthalate, Ricinoleic acid; Methyl -12-hydroxy-9-octadecenoate; Octadecanoic acid; Glycerin; 4, 6-Diphenyl-2-(2-hydroxyphenyl) pyrimidine, Eicosanoid acid, methyl ester, 2-Naphthalenol 2, 3, 4, 4a, 5, 6, 7-octahydro1, 4adimethyl-7-(2-hydroxy-1-methylethyl); Cholest-5-en-3-ol (3á), tetradecanoate; 6-Octadecenoic Acid; Oleic acid, 3-hydroxypropyl ester; Octadecanoic acid, 2, 3-dihydroxypropyl ester; Eicosane; Tert-Hexadecanethiol; 2-[4-methyl-6-(2, 6, 6-trimethylcyclohex-1-enyl) hexa-1, 3, 5-trienyl] cyclohex1en-1-carboxaldehyde; Spiro [4.5] decan-7-one, 1, 8-dimethyl-8, 9-epoxy-4-isopropyl; 9, 12, 15-Octadecatrienoic acid, 2, 3-bis [(trimethylsilyl) oxy] propyl ester, (Z, Z, Z). The phytoconstituents of methanolic extract of U. distachya has shown remarkable activities like antimicrobial, antioxidant, anti-inflammatory and anticancer...
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Posted by admin on May 31, 2022 in |
Background: Hypothyroidism is a metabolic disorder. Vitamin D is known to improve the impact of autoimmune diseases; hence, vitamin D supplements and adjuvant therapy can improve hormonal and metabolic imbalance along with oxidative stress. The study aims to determine the effect of Vitamin D on the oxidative stress parameter in hypothyroid patients compared to controls and hypothyroid subjects before and after vitamin D therapy. Methods: A prospective study of six months period was carried out among 120 subjects attending the General Medicine department. Age and gender-matched euthyroid controls (n=40) and patients who were newly diagnosed as hypothyroid (with increased serum TSH and or with decreased serum T3 or T4levels) were taken as cases (n=80). Serum TSH (mµ/L), T3(pg/m), and T4(ng/dl) levels were compared. Oxidative stress parameter (MDA) in hypothyroid patients is a tool to assess oxidative stress levels it was measured by using the Immunoassay method. Results: Oxidative stress parameter (MDA) in hypothyroid with and without vitamin D supplementation showed improvement indicating decreased levels in oxidative stress, along with statistical...
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