Posted by admin on Aug 31, 2023 in |
Medicinal plants belong to the Labiatae family, commonly known as the mint family. This family comprises the Anisomeles malabarica, which contain biologically important phytochemicals. Focus on solvent extraction of selected medicinal plant parts and its phytochemical analysis gives an insight for herbal drug discovery. A heat continuous percolation experiment was conducted for 24 hours using three different solvents, namely ethanol, methanol, and chloroform using the Soxhlet apparatus. The phytochemical examination of Anisomeles malabarica leaf extracts by the three solvents revealed that the extracts are abundant in alkaloids, saponins, tannins, flavonoids, and glycosides, all of which have been linked to the pharmacological effects of the plant. In the current study, derivatization procedures were employed to analyze both polar and non-polar compound present in the solvent extracts. Based on the GC-MS analysis, large amounts of carboxylic acids, which contain both saturated and unsaturated fatty acids, hydrocarbons, including alkanes and alkenes are responsible for the oily quality of all three extracts. According to analysis, the majority of polar molecules, such as alcohols,...
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Posted by admin on Aug 31, 2023 in |
Drug resistance in bacterial strains has often been detected in the last two decades and is increasing yearly. Novel survival mechanisms and over-the-counter antibiotic availability (OTC) complicated this issue, especially in relation to the Asian continent. Resistance to drug/antibiotic is multifactorial viz, plasmid encoding drug resistance, pumping the drug out by pumping mechanism from the bacterial cell, degradation of antibiotic by using enzymes such as β-lactamases, carbapenemase and others. Bacterial drug resistance is a global threat, and the discovery of novel antibiotics to address this challenge has not kept pace. Critical appraisal and drug development timelines in clinical phases made the task costly and tedious. Global pharmaceutical companies have withdrawn their attention, and only a limited number of companies are doing research and development in this field. The present review discusses the current scenario worldwide and introduces one health plan’s role in terms of the discovery of novel drugs and increased drug...
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Posted by admin on Aug 31, 2023 in |
Microbes are widespread and have been studied widely in recent years. Disease-causing microbes can also be called pathogens, germs, or bugs. These microbes are responsible for causing infectious diseases. Microbes are mediators in almost all ecosystem processes and act as a global pivotal game changer in various ecological activities. The therapeutic outcome with antimicrobial drugs depends totally on the selection of antimicrobial drugs. The choice of antimicrobial drugs depends on causative agents, patient factors, and clinical pharmacology of antimicrobial agents. The current review discusses how microbes can enter the human body through different sites and how antimicrobial drugs help cure various infectious diseases. Along with the same, the current review also represents how antimicrobial drugs affect the viability of microorganisms. The article also incorporates the prophylactic use of antimicrobial drugs. The main objective of the current review article is to give detailed knowledge about single, binary and tertiary combinations of antimicrobial drugs, analytical methods, and patent search of these...
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Posted by admin on Aug 31, 2023 in |
The development of Nanotechnology has paved the way to study various nanomaterials. Nanoparticles are structures that measure the size from 1-100nm. Widely used nanoparticles are usually prepared using noble metals, that is, gold, silver, palladium, and platinum. At the same time, they find their way into a wide range of applications in medicine, electronics, energy saving, environment, textile, cosmetics, biomedical, etc. The natural reducing agents in plants, such as carbohydrates, flavonoids, etc., reduce the silver, generating potential silver nanoparticles. Silver nanoparticles are intended to be used for the present study generated through green synthesis using millets. Millets are small-seeded grasses that are hardy and grow well in dry zones as rain-fed crops under marginal conditions of soil fertility and moisture. The different varieties of millets intended to be used in the project are Barnyard millet, Finger millet, Foxtail millet, Kodo millet, little millet, Pearl millet, Prosomillet, Sorghum. The Silver nanoparticles synthesized through an aqueous extract of different varieties were checked for their quality using UV-VIS spectrophotometer and Scanning electron...
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Posted by admin on Aug 31, 2023 in |
An example of the human microbiota is Staphylococcus saprophyticus, a gram-positive, non-hemolytic pathogenic bacterium. It’s a prevalent culprit behind simple infections associated with the urinary tract, especially among sexually active young women. It has a high colonization rate in the perineum, rectum, urethra, cervix, and gastrointestinal system and is also quite lethal. Because of their ability to form a biofilm, these bacteria are highly resistant to antibiotics. Thus, unconventional methods, such as the use of silver nanoparticles, have been devised to counteract this type of biofilm. The silver nanoparticles are produced in an environmentally friendly way by utilizing an extract of water from banana peels. UV/Vis, FTIR, SEM, and EDAX are the four methods used to characterize the NPs and validate their production. Using the Screening method and SEM analysis, we show that silver nanoparticles inhibit the growth of Staphylococcus saprophyticus ATCC 15305, the most prevalent bacteria responsible for urinary tract infections....
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