Posted by admin on Aug 1, 2014 in |
Piperine, a major alkaloid in black pepper is one of the most promising bioenhancers till date. Other methods used for its extraction suffer drawbacks such as poor extraction efficiency, tedious and expensive isolation methodology, piperine photodegradation, etc. Hence a simple, rapid and efficient method has been developed for the isolation of piperine from the fruits of Piper nigrum. The methods under study involve extraction of piperine with various solvents such as ethanol, glacial acetic acid and dichloromethane. Then isolation and purification were followed by separate classical methods for respective extracts. Compared to other two methods, the novel method using glacial acetic acid proved to be effective in isolating piperine with higher yield and in higher purity. Hence extract derived using glacial acetic acid was further subjected to column chromatography. Finally raisins removal and crystal formation were facilitated by recrystallization with solvent ether after alkali wash. Then identification of the compound was confirmed by various analytical methods TLC, melting point, UV-visible spectrophotometer, FT-IR, HPLC and compared it with authentic piperine...
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Posted by admin on Aug 1, 2014 in |
Background: Coronary heart disease is the most common type of heart disease and is the major cause of death in India and a major cause of death worldwide 1. It was thought previously to affect initially the higher income countries, but now CHD leads to more death in low- and middle-income countries such as India. Lifestyle modification is the main stay of treatment in preventing coronary heart disease. The intervention by pharmacists through pharmaceutical care program can be useful in reducing coronary heart disease risk factors such as increased blood pressure, high blood glucose, and high lipid levels 2-4. Objective: To study the impact of pharmaceutical care intervention on general cardiovascular risk and to assess 10-year cardiovascular risk using Framingham scoring method. Method: Hypertensive and diabetic patients (N = 104) aged >45 years of age were enrolled. Written informed consent was obtained from all the patients enrolled. The pharmacist’s intervention included counseling on smoking cessation, alcohol reduction, increased compliance, weight reduction, increased exercise, and dietary changes. The parameters measured...
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Posted by admin on Mar 1, 2014 in |
Jasminum multiflorum belongs to the Oleaceae family. It is used as a traditional medicine from ancient times. It is a large evergreen twinner shrub found throughout India. Present study reports the phytochemical properties which have been carried out on the leaves extract using ethanol, methanol, ethyl acetate, acetone and n-hexane. The phytochemicals analysis show the presence of Phenols, Saponins, Terpenoids etc; TLC has been carried out on different extracts of leaves of Jasminum multiflorum, which have shown different Rf values. The presences of phenols, terpenoids and saponins based phytochemicals are...
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Posted by admin on Feb 1, 2014 in |
The people in India have an outstanding knowledge of medicinal plants acquired over centuries.A passion for studying medicinal plants is evident both in folk and scholarly traditions. The indigenous mode of understanding and using plants is different from the modern scientific way. It includes botanical, medical and astrological elements. This is the basis of green pharmacy. Indians obviously care for medicinal plants because they know so many of them, so much about them and have worked extensively on their application. It is a remarkable fact that the use of medicinal plants is still a living tradition in the form of a million village-based folk carriers. These traditional birth attendants, bonesetters, herbal healers and wandering monks are invisible to policy makers and therefore not taken into account as a public health resource. Apart from these specialised folk healers there are also millions of women and elders with traditional knowledge of food and nutrition and herbal home-remedies. However, the revitalisation of this vast and diverse folk tradition does not appear on...
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Posted by admin on Feb 1, 2014 in |
The use of medicinal plants as raw material in the production of drugs is again gaining popularity. Monechma ciliatum has many traditional uses and applications in African folk’s medicines, e.g. the seed’s powder macerated in water and drunk or burnt as an inhalation for treatment cold and allergic conditions. The aim of this study is to formulate a suitable dosage form (tablets) from Monechma ciliatum seed’s ethanolic extract. In the process of formulating of low cost, safe, effective and reproducible dosage form the wet granulation method was used. After preformulation studies, two formulae were prepared, formula-1 by using starch as a binder and disintegrant, formula-2 by using polyvinyl pyrrolidine (PVP) and cross carmellose cellulose (CCS) as a binder and disintegrant respectively. The use of starch as disintegrant in tablets of formula- 1, gave the disintegration time of 8: 33 min: sec, while the disintegration time for tablets of formula- 2 was 11: 667 min: sec by using the high cost super disintegrant CCS. Coloring agent was not needed, as...
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