Posted by admin on Feb 28, 2017 in |
Vernonia polyanthes Less. (Asteraceae) is a medicinal plant that has been broadly used in Brazil for the treatment of inflammation and cutaneous damages. The present study evaluated the phytochemical contents and the antioxidant and topical anti-inflammatory activities of the V. polyanthes branches. Dried and powdered of V. polyanthes branches were exhaustively extracted with ethanol by static maceration followed by partition to obtain the hexane, dichloromethane, ethyl acetate, and butanol fractions. Phytochemical screening and the total phenolic and flavonoid contents were determined using chemical reactions and spectrophotometry, respectively. The antioxidant activity was evaluated by DPPH, reducing power of Fe+3 and β-carotene/linoleic acid assays. The topical anti-inflammatory effects of the ethanol extract (EEVPB) and ethyl acetate fraction (EFVPB) were investigated in Croton oil-, arachidonic acid-, and phenol-induced ear edema models. Tannins, flavonoids, coumarins, terpenoids and steroids, saponins and alkaloids were detected in the ethanol extract and/or fractions. In these samples, the total phenolic and flavonoid contents varied from 0.65 ± 0.07 to 12.58 ± 0.67 g/100 g and 0.15 ± 0.02...
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Posted by admin on Feb 28, 2017 in |
DM is characterized by insulin resistance and dyslipidemia, in particular, high levels of total cholesterol, triglycerides and LDL, and low levels of HDL-C, wich confer increased risk for CAD. Our study aimed to evaluate lipid profile in type 2 diabetic (T2DM) patients with coronary artery disease (CAD) in Tunisian population. Plasma levels of lipid profile variables were determined in 148 CAD patients with T2DM and in 159 patients with only CAD. Severity of CAD was quantified according to the prevalence of multivessel disease and the degree of coronary stenosis. Our results didn’t show any significant differences between diabetic and non diabetic patients in lipid profile variables. We didn’t found significant differences between the number of vessel disease and the extent of coronary stenosis, and lipid variables levels potentially reflecting the absence of a relationship between lipid profile and the severity of CAD. Using the receiver operating characteristic (ROC) curve that included all these variables, TG was found to be the single most powerful predictor of the severity of coronary...
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Posted by admin on Feb 28, 2017 in |
The aim of the study was to evaluate the central and peripheral analgesic activities of Solanum melongena ethanolic leaf extract in experimental animals. The Solanum melongena leaves were air dried at room temperature and were ground to a fine powder. Ethanolic extract was obtained by percolating the dried powder with 95% ethanol. Oral toxicity test was done according to OECD guidelines. For evaluation of central analgesic activity hot plate and tail flick methods were performed. These methods were carried out in healthy albino rats (Rattus norvegicus) of either sex weighing 100-200 gm. Thirty animals were used in each method. They were divided into five groups with six animals in each group for both methods. Solanum melongena ethanolic leaf extracts (500mg/kg) was used as test drug and Pethidine (5mg/kg) was used as the standard drug in these methods. For evaluation of peripheral analgesic activity, acetic acid induced writhing test was performed in albino mice. Total 18 healthy albino mice of either sex weighing 20–30 gm were used. They were divided...
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Posted by admin on Feb 28, 2017 in |
Pharmacy profession has responsibility for ensuring the safe, effective and rational use of medicines. Effective pharmacy practice requires an understanding of the social context which is practiced, innovative and informative. The aim of the study was to find out the Knowledge towards digital library and innovation in pharmacy practice by Questionnaire based Prospective study on pharmacy-medical professionals. The participant subjects to enrolled in study and asks self prepared 30 questions. The information’s were obtained on special form and data was analyzed by SPSS software. The result were found that 66.6% of participants were agrees that digital library makes treatment better where as 33.34% were not able to say about digital library role in better treatment outcomes. 53.33% thought that through 40 % slightly agreed. 56.66% study population positive to say the importance of electronic application of digital library minimize adverse drug reaction, 6.66% were not thought so and contents is increasing day by day in health care profession, 43.33% had negative thinking on the same. 73.33% said and agree...
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Posted by admin on Feb 28, 2017 in |
Lithiasis is the process of stone formation in the kidney, bladder, and/or urethra. Herbal drugs are reported to be effective in the treatment of urolithiasis with no side effects. Grewia asiatica is a plant commonly used as a traditional herbal medicine and possesses the wide range of pharmacological applications. The present study investigated the antilithiatic activity of an ethanolic leaf extract of Grewia asiatica Linn (EEGA). Ethylene glycol (0.75% in water) feeding resulted in hyperoxaluria as well as increased urinary volume and its pH. EEGA (200 & 400 mg/kg) was given orally in curative and preventive regimens over a period of 28 days. Supplementation with EEGA significantly (p<0.05) restored urea, uric acid, creatinine, volume of urine and pH levels. The preventive regimen was found to be better than the curative regimen. The results were comparable with the standard drug, Cystone (750 mg/kg). Histopathological examination further corroborated the antilithiatic or nephoprotective activity of the extract. The presence of triterpenoids, flavonoids and saponins in extract might be responsible for significant antilithiatic...
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