Posted by admin on Feb 28, 2017 in |
Arsenic has become a major problem in arsenic contaminated areas today. Its consequences on human health have been increasing with an alarming rate. Apart from toxicological effects caused by arsenic accumulation in the body, it causes several disorders including male infertility. Arsenic has been implicated to expedite the generation of ROS and hence lipid per-oxidation leading to DNA damage, apoptosis, and malfunction of several proteins and enzymes. Reduced number of sperm cells and testosterone level is evident in myriad of literatures. Swiss albino mice were grouped as control and arsenic treated. Weight of testes of mice after arsenic treatment was found to be lower than that of control group with p-value <0.0001. Similarly, sperm count and testosterone levels were also lower in arsenic administered group as compared to control group with significance < 0.0001. Unlikely, MDA level in arsenic treated mice was higher than control mice (p-value<0.0001). Moreover, histological sections unravels significant issues related to arsenic toxicity and DNA damage can easily be traced in testes of arsenic treated...
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Posted by admin on Feb 28, 2017 in |
The objective of the present study was to evaluate the anti-diabetic and hypolipidemic activity of methanolic extract of whole plant of Aristolochia bracteolata (MEAB) against streptozotocin (STZ) induced diabetic rat model. Glibenclamide was used as standard drug. The MEAB was administered orally at a dose of 200 & 400 mg/kg bd. wt and blood glucose levels were determined on 0th, 7th, 14th, 21st and 28th day. MEAB was found to significantly reduce blood glucose levels in streptozotocin induced diabetic rats. Reduction in blood glucose levels were observed from 7th day onwards, after continuous administration of the extract. The effect of MEAB on serum lipid profile like total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL) and high density lipoprotein (HDL) were also measured on 28th day in the diabetic rats. There was significant reduction in total cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. The results indicated that Aristolochia bracteolata possesses significant anti-diabetic and hypolipidemic...
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Posted by admin on Feb 28, 2017 in |
In recent times, the use of natural antioxidants as ameliorative agents has become the focus of basic research. Allium sativum (garlic) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the induced renal toxicity of the antimalarial drug, artesunate, which has been used as an alternative antimalarial drug against conventional drugs like chloroquine. Thirty six male mice were divided into six experimental groups. In the present study, Allium sativum was given at 100 mg/kg body weight with low dose (150 mg/kg body weight) and high dose (300 mg/kg body weight) of artesunate for 14 days and 21 days duration. Obtained results showed significant alterations in gravimetric indices as well as biochemical parameters. Moreover, administration of Allium sativum exhibited recovery and reestablishment of various altered indices in renal tissue as opposed to artesunate treated groups. This study obviously demonstrated that treatment with Allium sativum significantly attenuated the renal toxicity...
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Posted by admin on Feb 28, 2017 in |
There is a lot of thrust on utilization of bioactive chemicals from plant systems and their significant effect on microorganisms. Ten species of plants of the family Euphorbiaceae have been used for our study they are, Croton bonpandianum, Euphorbia tirucalli, E. hirta, E. heterophylla, Jatropha curcas, J. glandulifera, J. multifida, Phyllanthus amarus, Ricinus cummunis, Pedilanthus tithymaloides. Most of the family members of Euphorbiaceae have unique feature of possessing latex in their plant body. This latex is a secondary metabolite and hence has no significant physiological role in the plant system. An attempt has been made to find whether the plant extracts prepared in water have any role against fungi. These fungi are pathogenic to both plants and animals. The stem and leaves are thoroughly washed in 1% mercuric chloride and later washed in tap water followed by double distilled water. Later on crushed in mortar and pestle using water. The fungal species used for our study are Aspergillus niger, Saccharomyces cerevisiae and Fusarium oxysporum. The extracts are directly used...
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Posted by admin on Feb 28, 2017 in |
AEG-1 expression is known to elevate in diverse cancers, where it plays a primary role in activating multiple signaling pathways that drives copious oncogenic properties. The versatile role of AEG-1 in mediating oncogenesis was found to be cognate with numerous signaling cascades such as the activation of NF-κB/p65, Ha‑Ras, PI3K/Akt, ERK/MAPK, Wnt/β-catenin, AURKA and RNAi pathways. In addition, recent clinical studies reveal that AEG-1 interaction with SND1/AGO2 in RISC may stimulate oncogenic transformation. The defeat of AEG-1 leads to PARP cleavage catalyzed by caspase-3, a key process in mediating apoptosis in AEG-1 expressed cancer cells. Moreover, AEG-1 confers chemo-résistance of cancer cells by inducing autophagy. In recent past, there are several studies reveal that AEG-1 down regulation inhibits chemo-resistance and oncogenic properties of various cancers. With this background, this review will address the multifaceted role of AEG-1 as oncogene and stipulating its potential to become a new therapeutic target and prognostic biomarker for the treatment of...
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