Posted by admin on Oct 31, 2017 in |
Middle East Respiratory Syndrome (MERS) is viral respiratory illness that was lately recognized in human. It was first testified in Saudi Arabia in 2012 and has since spread to numerous other countries, as well as the United State. Record people well-known as infected with MERS-CoV developed numerous acute respiratory illnesses, including fever, cough and shortness of breath. Middle East Respiratory Syndrome (MERS) is an illness initiated by a virus (more specifically, a coronavirus) called Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Around 3 to 4 out of every 10 patients reported with MERS have died. The biggest known outbreak of MERS outside the Arabian Peninsula occurred in the Republic of Korea in 2015. The outbreak was allied with a traveler returning from the Arabian Peninsula. MERS-CoV has spread from ill people to others through close contact, like caring for or living with infected person. MERS can affect everyone. MERS patients have ranged in age from younger than 1 to 99 years old. No vaccine available against MERS. The U.S. National Institutes...
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Posted by admin on Oct 31, 2017 in |
Poor flow and cohesion are the most common problems encountered during manufacturing of a tablet. Tablets are produced by compression of formulation ingredients including the drug and excipients that improve processing properties of the product. Excipients may include fillers, diluents, binders, lubricants etc. which are added to impart good flow. Cellulose and Lactose have been widely used in Pharmaceutical Industry as a binder and filler due to their property of excellent flowability and stability. The aim of the experiment is to prepare granules of two co-processed excipients of lactose monohydrate and cellulose using water as a binder and compare their flow properties. Although these excipients can be directly compressed, we use wet granulation technique since it allows the material to be compressed with better flow properties. In Wet granulation technique, the particle size, shape and size distribution are optimized with the use of binder that bonds the powder particles together forming spherical granules. In Cuisinart mixer, 700g of powder was mixed with continuous addition of water for 30 seconds...
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Posted by admin on Oct 31, 2017 in |
Pyrazinamide is an important anti-tubercular drug which shortens the course of TB chemotherapy. A direct injection liquid chromatographic method is developed for the determination of pyrazinamide in pharmaceutical formulation. The method includes a micellar mobile phase containing 0.15M sodium dodecyl sulphate and 1% butanol (v/v) buffered at pH3, a Princeton SPHER-100 C18 column (250mm × 4.6mm, 5µm particle size) and UV detection was set at 269nm. The Micellar Liquid Chromatography (MLC) method is rapid, precise, sensitive, and robust. In this method pharmaceutical samples were directly injected to the column without pre- treatment step. Under all these conditions, method has very short analysis time of 3.2 min, linearity (r > 0.998), limit of detection and limit of quantification is 1.4, 36.5 ng/ml respectively; Intra – and inter-day precision (RSD%) were 1.5, overall recovery in pharmaceutical formulation is 99.4%, 69.5%, 81.25%, 87.9%. The method is suitable for routine quality control analysis. This chromatographic techniques, MLC has the advantage of avoiding sample extraction step from matrices, thus reduces the time of...
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Posted by admin on Oct 31, 2017 in |
In the present study Terminalia bellirica seeds, were evaluated for the In vitro anti-oxidant activity and phytochemical evaluation using different solvents such as methanol, ethylacetate, chloroform and aqueous. The in vitro antioxidant activity of Terminalia. bellirica is screened by standard antioxidant assays such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, hydroxyl radicals and Total antioxidant activity by ABTS assay. The ethylacetate extract of T. bellirica seed extract was found to be relatively high activity (84±0.6) than other extracts. Similarly the ethyl acetate exhibits high antioxidant status in ABTS and hydroxyl scavenging assays. In comparison to other extracts the ethyl acetate and methanolic extract found significant and prominent antioxidant activity due to the presence of high phenolic and steroid content. Finally this study concludes that all the seed extracts of T. bellirica exhibiting high antioxidant potential with respect to dose depending...
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Posted by admin on Oct 31, 2017 in |
Here, we evaluated the in vitro antileishmanial activities of Olea europaea linn. leave extract (OLE) on some Leishmania spp. OLE (0–160 ?g/mL) was considered against promastigote and intracellular amastigote forms of L. tropica (MHOM/IR/2002/Mash2) and L. major (MRHO/IR/75/ER) using MTT assay and in a macrophage model, respectively. The obtained findings demonstrated that OLE significantly (?<0.05) inhibited the growth rate of promastigote and amastigotes as a dose and time dependent response. To conclude, the current investigation exhibited effective antileishmanial activity of...
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