Posted by admin on Dec 31, 2016 in |
Five novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors (1a–e). They were characterized by different techniques. The antimicrobial activities of these compounds were tested. The compounds showed moderate activity against three Gram (+) and seven Gram (-) bacteria in comparison to tetracycline, which was used as the standard antibiotic, whereas all the compounds (1a-e) showed no activity against the test yeast C....
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Posted by admin on Dec 31, 2016 in |
Introduction: Measurement of glycated hemoglobin (HbA1c) and fructosamine has a growing role in the assessment of glycemic control but their use for screening purpose is questionable. Material and methods: The study was carried out on 50 controls and 50 patients suffering from hyperthyroidism from October 2014 to March 2015 at Geetanjali Medical College & Hospital, Udaipur (Rajasthan). Results: Fructosamine in hyperthyroid subjects (male & female) and control male & female (Mean ± SD) 141.87 ±41.14, 149.35 ± 49.82 and 223.54 ± 9.95, 224.15 ± 9.06 µmol/L respectively and the difference between them found statically significant. (P<0.001) Conclusion: The Fructosamine level was low in hyperthyroid patients as compared with...
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Posted by admin on Dec 31, 2016 in |
Ultrasound-assisted dispersive liquid-liquid micro extraction (UA-DLLME) was proposed for simultaneous determination of trace levels of Vitamin B1 (thiamine) and Vitamin B9 (folic acid) in the human urine and serum samples. High performance liquid chromatography (HPLC) coupled with chemometrics method was employed to analysis the extraxtants. Objective: The optimal conditions of the extraction recovery, including pH of sample solution, type and volume of extraction solvent, disperser solvent type and volume, temperature and time of ultrasound, centrifugation time and ionic strength were were studied step-by-step via one-factor-at-a time procedure. Then significant variables were chosen and considered to further optimize using the hybrid Box–Behnken design -genetic algorithm. UA-DLLME method with HPLC-UV and utilizing hybrid Box–Behnken design -genetic algorithm to optimize the extraction process was presented for the first time in this study. Under the optimized extractions, relative standard deviations (RSD) of the analyses less than 4% (n= 3) and detection limit of 3.09-11.15 ng mL. Recoveries for both thiamine and folic acid were in the ranges of 88–107%. As the result, the...
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Posted by admin on Dec 31, 2016 in |
Ethonolic whole plant extract of Musa paradisica has a multiple pharmacological activities including antimicrobial, antiviral, anti-inflammatory, anticancer effects. The present study aims to determine the effect of Musa paradisica on serum and tissue superoxide dismutase (SOD) levels and the histology in carbon tetrachloride (CCl4)-induced liver injury. Wister rats aged were injected Intraperitoneally with 50% CCl4 in olive oil. Musa paradisica was orally administered before or after CCl4 treatment in various groups. Twenty-four hours after CCl4 injection, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, serum and liver superoxide dismutase (SOD) activities were measured and Histological changes of liver were examined by microscopy. Serum ALT and AST activities significantly decreased in a dose-dependent manner in both pre-treatment and post-treatment groups with ethonolic whole plant extract of Musa paradisica. The present study demonstrates that Musa paradisica possesses hepatoprotective effects against CCl4– induced hepatotoxicity and that the effects are both preventive and curative. Musa paradisica should have potential for developing a new drug to treat liver...
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Posted by admin on Dec 31, 2016 in |
Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and noninflammatory (comedones, open and closed) lesions. A lot of factor viz; hormone, increased sebum production and diet causes Acne vulgaris but bacteria are the chief causal organism in which Propionibacterium acnes and Staphylococcus epidermidis are considered as the major skin bacteria that cause the formation of acne. The present study was conducted to evaluate the in vitro antimicrobial activities of Psidium guajava L. leaves essential oil against Propionibacterium acnes and Staphylococcus epidermidis. Extraction of essential oil was carried out using Clevenger’s Apparatus. Antibacterial activities of essential oil of leaves were investigated using broth micro dilution methods recommended by CLSI. The results showed that Guava leaves oils more effectively inhibit the growth of P.acnes (MIC: 0.321, IC50:0.309 mg/ml) as compared to S. epidermidis (MIC: 0.486, IC50:0.416 mg/ml). The readings were compared by standard drug...
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