Posted by admin on Nov 30, 2017 in |
Drug interaction generally refers to a modification of the expected drug response in the patient as a result of exposure of the patient to another drug or substance. Some unintentional drug interactions produce adverse reactions in the patient, whereas some drug interactions may be intentional, to provide an improved therapeutic response or to decrease adverse drug effects. They are divided into three groups depending on the underlying mechanism of interaction: pharmaceutical, pharmacokinetic or pharmacodynamic...
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Posted by admin on Nov 30, 2017 in |
A topological index is a numeric quantity associated with a graph which characterizes the topology of the graph and is invariant under graph automorphism. Topological indices such Randić, atom-bond connectivity (ABC) and geometric (GA) indices are used to predict the bioactivity of different chemical compounds. Recently, the edge version of atom-bond connectivity and geometric arithmetic indices of graph G are introduced based on the degree of an edge of line graph of G. In this paper, the closed formulas of edge version of atom-bond connectivity and geometric-arithmetic indices for V- Pantacenic nanotube are...
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Posted by admin on Nov 30, 2017 in |
Objective: To study qualitative and quantitative estimation of phytochemicals and determination of total phenol and flavonoid content in plant parts of Mimusops elengi Linn. Methods: The solvents methanol, ethanol, aqueous and petroleum ether are used for extraction of Mimusops elengi Linn. plant parts. Phytochemical screening of plant parts was carried out in all the solvents. Quantitative estimation of carbohydrate, protein and lipids was done according to the established protocol. Determination of total phenol content was carried out using Folin – Ciocalteau method and total flavonoid content using Aluminium chloride colorimetric method. Results: The result revealed the presence of carbohydrates, alkaloids, flavonoids, tannin, saponin and terpenoids etc. Total phenol content was expressed in mg of Gallic Acid Equivalent (GAE) per g of dry weight. In results it was found that petroleum ether extract shows highest phenol content 267.20 mg/g in fruits. The content of flavonoids was expressed in mg of Quercetin Equivalent (QE) per g of dry weight. It was evaluated that total flavonoid content found highest in bark 113.35...
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Posted by admin on Nov 30, 2017 in |
Cotoneaster is a plant from Rosaceae family and produces a sugary secretion (manna). Manna is the most important constituent of species of this plant. Manna consists of different types of carbohydrates, and other phytochemicals. Sugar characterization, including reducing sugar was assayed by cupric/sodium carbonate spectrophotometric method. In addition, the composition of individual sugars was also determined using high-performance liquid chromatography (HPLC) coupled with a refraction index (RI) detector, with mannitol being the most abundant sugar. Also, amount of essential microelements was determined using flame atomic absorption spectrometry. Finally, total flavonoid content in all Cotoneaster species was determined using the aluminum chloride method. According to HPLC-RI data, C. nummularioides manna has a high percentage of mannitol (88.69±0.05) and low amount of sucrose (5.37±0.01). Total reducing sugar of the C. discolor is the lowest and in C. nummularius is the highest among all mannas. The study shows differences in sugar profile, essential microelements, and total flavonoid content. Mannas from Cotoneaster species have different carbohydrate profiles and other phytochemicals and have different...
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Posted by admin on Nov 30, 2017 in |
Antimicrobial resistance has been called one of the world’s most pressing public health problems. Addressing the issue of antimicrobial resistance is one of the most urgent priorities in the fields of public health today. Alarmingly, the development of resistance such as multi-drug resistance towards a number of antibiotics poses a challenge to the scientific community in the discovery of new therapies. Thus, there is a need to develop newer and effective molecules with high safety profile. Benzothiazoles are fused membered rings, which contain heterocycles bearing thiazole. Sulphur and nitrogen atoms constitute the core structure of thiazole and many pharmacologically and biologically active compounds. Benzothiazole is an interesting pharmacophore exhibiting diverse pharmacological activities like antimicrobial, anticancer, anthelminthic, antidiabetic, antitubercular, anticonvulsant, antioxidant, anti-inflammatory, antifungal, antipsychotic etc. The present article extensively covers various procedures of synthesis of 2-substituted benzothiazole core and its analogs – by utilizing distinctive catalysts, solvent conditions, reactants immobilized on solid support and microwave irradiation. Variations in synthetic procedures are studied to explore chemo-selectivity of the reactions, in-expensive, eco-friendly,...
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