Posted by admin on May 31, 2017 in |
Borassus flabeliffer Linn. (Palmyra Palm) is widely distributed in the Northern parts of Sri Lanka. Its leaves, fruits and pith have various uses. Palmyra based industries provide living for many families in that region. Palmyra pulp obtained from the ripe fruit is used in many traditional food items in the Jaffna Peninsula and surrounding areas. It is also being used in folk medicine to cure various diseases. In this study, total phenolic content and antioxidant activity of aqueous palmyra fruit pulp extracted from fruits of Kilinochchi, Anamaduwa and Batticalo districts of Sri Lanka were evaluated. The total phenolic content of the pulp extracts of fruits obtained from Anamaduwa district showed the highest value (9.297 ±0.018 mg GAE/mg extract). DPPH Radical scavenging activity was seen highest in the Anamaduwa samples (3.065 ±0.176 mg ml-1) and lowest in Batticalo sample (7.466 ±0.156 mg ml-1). The total antioxidant capacity based on the phosphomolybdenum assay also indicated the highest value in the Anamaduwa sample (68.171± 2.068 mg AE/g extract) and lower value in...
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Posted by admin on May 31, 2017 in |
A reverse phase high performance liquid chromatography (RP-HPLC) method was developed and validated for the determination of Atenolol (ATN) in bulk and pharmaceutical formulation. The method was optimized selecting chromatographic conditions of 60: 40 acetonitrile: water, Inertsil_ column(ODS-3 250 mm × 4.6 mm 5 ?m), 20 ?L injection volume, flow rate of 1 mL/min at ambient temperature (30 °C), and 276 nm. Using two HPLC systems of first HPLC system coupled with PDA detector and the second HPLC system coupled with UV detector showed no big difference in the method results. The method was validated giving good precision (RSD% < 1), acceptable linearity (R2 > 0.998), and low LOD and LOQ (0.5 and 1.5 ?g/mL, respectively) on both systems. Successful application on pharmaceutical dosage tablet form gave high recovery of 97.7%. The proposed method is economic, simple, and rapid and hence can be employed for routine analysis in quality control...
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Posted by admin on May 31, 2017 in |
Background: Antiaris toxicaria is a tree in the mulberry and fig family of Moraceae. The leaf is used to remedy various ailments but the preparation depends on individuals. There is a need to set a standard for its preparation that would ensure optimum therapeutic benefits. Medicinal plants are generally reputed as cheaper and safer alternatives to synthetic drugs but these are often adulterated with inferior materials thereby affecting the overall therapeutic advantage. Pharmacognostic studies on such medicinal plants are therefore necessary to set standards for the preparation of herbals. Materials and Methods: Macroscopic and microscopic studies, including anatomical sectioning, chemo-microscopic, fluorescent analysis, and numerical and quantitative leaf microscopy were evaluated according to standard and reported method. Results: The leaf is simple, lanceolate or oblong, alternate, with reticulate venation, acute apex and cuneate base. Types of calcium oxalate crystals found were rosettes and prisms. Stomata are anomocytic with epidermal cells radiating around the stoma. Leaf is isobilateral. It has cellulose, tannins (condensed), calcium carbonate, fats and fatty oils, proteins, lignin,...
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Posted by admin on May 31, 2017 in |
One of the factors responsible for malaria pathogenesis is the suppression of host immune responses. This suppression enhances parasitemia and diminishes the host immune response to malaria-expressed proteins and other pathogens. Hemozoin is a key metabolite associated with severe malaria anemia (SMA), immunosuppression, and cytokine dysfunction. Targeting of this pigment may be necessary in the design of new therapeutic products against malaria. In the present research, some novel compounds are synthesized and targeted against hemozoin growth. The consideration of new chemotherapeutic targets in malaria research is most likely to identify new classes of drugs. The present work deals with the synthesis of a small library of 2-alkoxy/phenoxy-3-amino-3-arylpropan-1-ols by reductive ring opening of the corresponding azetidine-2-ones. After characterization of synthesized compounds, these were evaluated for hemozoin formation inhibition assay. The results showed that all compounds are inhibiting hemozoin formation comparable to Clotrimazole. This may be concluded that the synthesized compounds exhibit antimalarial activity via inhibition of hemozoin...
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Posted by admin on May 31, 2017 in |
Background: According to World Health Organization the global prevalence of musculoskeletal disorder ranges from 14% to as high as 42%.Teachers are generally prone to neck, shoulder and low back pain . The work tasks of school teachers often involve significant use of a head down posture, such as frequent reading and marking of assignments. According to World Health Organization working with a heavily bent, extended or twisted trunk can result in an overload of spinal structures and increased activity of the entire muscles. Objective: To find out the prevalence of musculoskeletal disorders and awareness of physiotherapy management among the primary school teachers. Study Design: Non-experimental. Subjects: 340 samples. Permission from the Institutional head along with the concerned teachers was taken initially to conduct the study. Prior information about the study was given. The purpose of the study was explained to all the subjects to take part in the study. The subjects were selected based on the inclusion and exclusion criteria. Then the “Extended Nordic musculoskeletal questionnaire’’ and the “Physiotherapy...
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