Posted by admin on May 31, 2017 in |
Cinnamaldehyde is derived from the cinnamon essential oil (EO) having many biological and pharmacological significance. This review article explains the source, chemistry, physico-chemical characteristics of the molecule. The synthesis of its different analogous has been duly highlighted. The different applications narrating the various usage have been reported. It is expected that this review shall serve as a base material for future research in various...
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Posted by admin on May 31, 2017 in |
Up to 40% of new chemical entities (NCEs) discovered today by the pharmaceutical industry through combinatorial chemistry and high through put screening are highly lipophilic or poorly water soluble compounds, so the number of such compounds has dramatically increased and the solubility behaviour of these drugs has become one of the most challenging aspects in formulation development. So amongst the vast majority of strategies (like particle size reduction, use of surfactants, cosolvency, hydrotrophy etc) already reported in the literature to resolve this issue, solid dispersions have emerged as an advanced technique of improving the solubility/dissolution rate and hence, the bioavailability enhancement of a wide range of poorly water-soluble drugs. This review article mainly focuses on solubility ranges, biopharmaceutical classification system (BCS), list of poorly soluble drugs, commercial preparations, classification, types, advantages, limitations, methods of preparation and characterization of solid dispersions. In this review, besides above it is intended to discuss the recent advances and future prospects related to the solid dispersion...
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Posted by admin on May 31, 2017 in |
Objective of the present work was to evaluating the antidiabetic property of Kandelia candel and Rhizophora apiculata extracts by using in vitro assays. The serial exhaustive extraction was carried out with a series of solvents: chloroform, ethyl acetate, methanol, ethanol and water with increasing polarity using Soxhlet apparatus. The concentrated and dried extracts were evaluated for antidiabetic activity by employing standard in vitro techniques (Alpha-amylase and glucose uptake assay using yeast model). In vitro antidiabetic studies show that in case of Kandelia candel methanol extract showed higher antidiabetic activity where as incase of Rhizophora apiculata aqueous extract exhibited significant activity when compared to other solvent extracts. Results confirm that aqueous extract of Rhizophora apiculata exhibited highest antidiabetic activity among all extracts. This study provides scientific evidence that the leaves of Kandelia candel and Rhizophora apiculata have anti-diabetic efficacy. However further comprehensive chemical and pharmacological investigation should be carried out to isolate the active compounds and appropriate elucidation of its mechanism of action and it helps in the development of...
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Posted by admin on May 31, 2017 in |
Dental biofilms are majorly developed by Streptococcus mutans, a cariogenic microorganism and are one of the major effects of glucosyltransferases (Gtf) produced by it. This study was conducted to determine the antagonistic potential of probiotic bacteria against S. mutans biofilm formation. We studied the anti-biofilm formation ability of three Lactobacillus species viz L. rhamnosus, L. acidophilus and L. plantarum. Inhibition of biofilm formation was checked on a cell culture cluster. The samples with robust inhibitory activity were selected to check their effect on Gtf activity by estimating the changes in the amount of glucan synthesized, the Gtf catalyzed reaction product. The results showed that, the cell free broth of L. plantarum and L. acidophilus has significant inhibitory and displacement activity on biofilm formation by the cariogenic organism when employed individually and in combination. Further, the interference (80% reduction) in glucan synthesis observed by applying these lactic acid bacteria (LAB) samples suggested their possible role in inhibition of glucosyltransferase (insoluble) [Gtf-I]. In conclusion, our studies demonstrated repressive activities of two...
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Posted by admin on May 31, 2017 in |
Synthesis of metal nanoparticles has become an important branch of nanotechnology and there is an increasing commercial demand for nanoparticles due to their wide applications. The present study was carried to synthesize silver nanoparticles (AgNPs) using the ethanolic extract of the Leucas aspera and evaluate its in-vitro anti inflammatory activity. The synthesis was done by using the ethanolic solution of L. aspra extract and AgNO3. The AgNPs were characterized using UV-Spectroscopic analysis, Scanning Electron Microscopy (SEM), Fourier Transform Infra Red Spectroscopy (FTIR) analysis. UV-Vis spectral analysis shows a maximum absorption peak at 421.00 nm. The FTIR spectra of AgNPs exhibited prominent peaks at 3697cm-1,1761cm-1,1390cm-1, 831cm-1 which are associated with OH stretching, C=C stretching, CH stretching respectively. The SEM analysis of the synthesized AgNPs clearly showed the clustered and irregular shapes, mostly aggregated and having the size of 25-80 nm. The synthesized AgNPs exhibited an enhanced anti inflammatory activity due to the synergistic effect of phytoconstituents in L. aspera extract and the silver...
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