Posted by admin on May 31, 2017 in |
Snakehead fish powder containing albumin has macromolecule size which is difficult to penetrate into membrane cell. So, It was formulated into nanoemulsion utilizing the best comparison of surfactant, co-surfactant and oil. Nanoemulsion of snakehead fish powder was characterized by particle size analyzer. The snakehead fish were extracted by atomizer (-40 °C, 1atm) to gain powder which was formulated into nanoemulsion by spontaneous emulsification method using the best comparison of oleic acid, propylene glycol and Tween 80 (1:10). Propylene glycol was added into Tween 80 and oleic acid and stirred until homogeneous mixture. Then water, containing 0.125% of snakehead fish powder, was added drop by drop until becoming a transparent solution by sonication. It was characterized by UV-Vis Spectrophotometry and Particle Size Analyzer. The results of this research showed that snakehead fish nanoemulsion generated clear, stable, and translucent formula having the transmittance value of 100%. The characterization results described nanoemulsion had the average particle size of 147.63 nm. Meanwhile, the average of polydispersity index and zeta potential values were 0.234...
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Posted by admin on Apr 30, 2017 in |
Natural pigments have great interest with in the market now a day’s particularly microbial pigments. The various microorganisms such as Micrococcus, Bacillus, Rhodotorula, Monascus, Phaffia, Sarcina and Achromobacter have the capability to produce different pigments. These colors have number of beneficial properties like anti-cancerous, immunosuppressive, antibiotic, anti-proliferative, bio-degradability etc. Further, they have broad area of application mainly in food, dairy, printing, textile and pharmaceutical industries etc. Since, the microorganisms are a significant source of carotenoids and major source of naturally occurring pigments. These carotenoids basically protect cells against photo oxidative damage and hence have vital applications in environment, food and nutrition, disease control, and as potent antimicrobial agents. Use of microbial pigments in processed food is another promising area with large economic potential. However, microbial pigments provide challenges due to lower stability, high cost and variation in shades due to changes in pH. Further, it is also essential to have toxicology studies of these microbial pigments before their use as natural colorants in food...
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Posted by admin on Apr 30, 2017 in |
Polypharmacy may affect patient’s QOL. Polypharmacy has been shown to result in Unnecessary and/or inappropriate medication prescribing, increased risk for drug interactions and ADRs, Non adherence, and increased overall drug expenditures. That’s how poly pharmacy affects patient compliance. A retrospective study was conducted about the polypharmacy and medication compliance in patient with type 2 diabetes in various teaching hospitals of Lahore. 19% of patients were prescribed at least one diabetes related medicine and 81% was prescribed more than one diabetes related medicines. 100 patients surveyed were taking a ∑ of 4 medicines per patient to control diabetes and related comorbidities for a total of 378 medicines. Despite the complexity of medical regimens, patients reported high level of compliance for each diabetes related medicine 92% of the prescribed doses were taken with the 6% of missing doses. It was concluded that despite the complexity of medical regimens, patients reported high level of compliance for each diabetes related medicine. Patient’s perception of the immediate and future benefit of prescribed medication had...
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Posted by admin on Apr 30, 2017 in |
Piperidine is a key structural motif in various alkaloids and a variety of compounds studied in medicinal chemistry. Though many methods have been developed for their construction, there is still need for noval approaches. Among the wide variety of heterocyclic compounds; piperidin-4-ones exhibit various biological activities. Synthesis and biological applications of piperidin-4-ones derivatives are outlined in this...
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Posted by admin on Apr 30, 2017 in |
Cisplatin is a cytotoxic drug which induced the hepatotoxicity in the albino mice when intra-peritoneally administered at the dose of 10mg/kg. Administration of cisplatin raised the level of LFT’s enzymes and also reduced the level of antioxidant enzymes in the liver of the mice. Administration of Cuminum cyminum, Phyllanthus emblicus extract and silymarin remarkably showed the hepatoprotective effect in the albino mice. Administration of C. cyminum, P. emblica and silymarin decreased the level of ALT, AST, and ALP along with increasing the level of Total protein content. It also increased the level of antioxidant enzymes in the liver of mice showing its hepatoprotective activity. We found C. cyminum has a better hepatoprotective effect than P....
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