Posted by admin on Sep 30, 2022 in |
Cariogenic organisms are responsible for producing and developing tooth decay, which ends up in dental caries. It is commonly seen in both children and adults. The aim was to evaluate anticariogenic activity of Commiphora caudata leaf extract. Two different solvents such as acetone and 70% ethanol used against Lactobacillus casei and Streptococcus mutans. Agar well diffusion method and minimum inhibitory concentration (MIC) was used for this purpose. Ethanolic extract showed significant antibacterial activity against the tested organisms. Preliminary phytochemical screening of the extract revealed the presence of steroids, phenols, flavonoids and coumarins in both acetone and ethanol extract. The above observations remarkable cariogenic inhibition, which may be due to these active secondary metabolites. This may potentially treat dental caries and be used as lead(s) molecules in the development of new antimicrobial drugs against cariogenic...
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Posted by admin on Sep 30, 2022 in |
The aim of the present In-silico studies is to find out the potential protein target and find out the 3D structure of crustin antimicrobial protein in Portunus trituberculatus. Crustin are small cationic proteins assumed to be antimicrobial effectors against mainly Gram-positive bacteria. The swimming crab Portunus trituber-culatus is a commercially important crab species in East Asia countries. Gonadal development is a physiological process of great significance to reproduction and commercial seed production for P. trituberculatus. The nucleotide and protein sequence of crustins protein from P. trituberculatus is retrieved from the NCBI database in Fasta format. Further, the primary and functional analysis of crustin protein was done through protparam and helix turn helix tools. The retrieved protein sequence was applied to an advanced protein modeling server Cph to deliver the 3D structure. After modeling, the protein’s three Dimensional structure was viewed with Discovery studio software’s help. Our method enables the production of new antimicrobial peptides as potential next-generation...
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Posted by admin on Sep 30, 2022 in |
Proximate composition, qualitative screening for phytochemicals (terpenoids, steroids, tannins, oxalates, coumarins, phenols, saponins, and flavonoids) and antioxidant properties in four selected indigenous oilseeds: morama (Tylosema esculentum), mongongo (Schinziophyton rautenenii), mogose (Bauhinia petersiana) and kgengwe (Citrulus lanatus (Thunb.) Mansf.) from Botswana was examined. A significant difference (p≤0.05) was observed in the moisture, fat, protein, ash, carbohydrate, and energy contents. The values ranged from 3.87 – 7.27, 15.99 – 57.70, 12.44 – 33.76, 3.07 – 6.07, and 6.31 – 60.01%, respectively, while the range for the energy content was from 422.35 to 655.29 kcal/100g. Only oxalate was not detected in the qualitative tests performed for eight (8) phytochemical compounds with six (6) solvent extracts. The highest total phenolic content was recorded in morama seeds (1.72 mg GAE/mL), while total flavonoids were better in mogose (0.00813 mg CE/g) and kgengwe (0.00404 mg CE/g). The vitamin C equivalent antioxidant capacity (VCEAC) for mogose, morama, and kgengwe were 2.39, 2.07, and 0.78 mg/100 g, respectively. The study indicated that the oilseeds could potentially be...
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Posted by admin on Sep 30, 2022 in |
An introduced, non-native, exotic, or alien species are those that grow in areas outside of their natural habitats. They get introduced deliberately or accidentally into new areas by anthropogenic activities or naturally through water, wind, etc. In non-native areas, these species invade rapidly due to the non-availability of natural enemies (prey) in a new habitat. Therefore, these fast-spreading exotic species are called invasive alien species. Verbesina encelioides, an invasive species of the family Asteraceae, is introduced from the United States and started to invade many arid or semi-arid regions. It is commonly known as ‘Golden crownbeard’. The weed is used as a source of traditional medicines by the indigenous people. Some researchers investigated its toxic, allelopathic, antimicrobial and nematocidal properties. Its phytochemical analysis has shown the presence of flavonoids, terpenoids, alkaloids, carbohydrates, saponins, phenolic compounds, sterol, etc. The pharmacological studies showed this plant’s antibacterial, antitumor, antifungal, antiprotozoal and hypoglycemic potential. Attempts have been made to cover various aspects related to V. encelioides in this review...
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Posted by admin on Sep 30, 2022 in |
Wattakaka volubilis (L. f) Stapf, belonging to the family of Asclepiadaceae, has a history of use in traditional medicine in numerous countries. Traditionally the plant has been used for the treatment of diabetes, eye infections, snake bites, boils, skin problems, jaundice etc. A tribal community called Kurinjan has been using this plant to reduce blood glucose level. This plant is a tall woody climber with ash-colored older branches and green or yellowish green flowers that fall in umbellate cymes. The review demonstrates that the plant has a large number of phytochemical elements with activities such as Anti-diabetic, Antioxidant, Anti-inflammatory, Analgesic, Antipyretic, Anti-tumour, Antimicrobial etc. The phytochemicals present are Alkaloids, Flavanoids, Tannins, Glycosides, Anthocyanidins. Phytochemicals such as Drevogenin, Delphinidine, Dregein, Dregeosides have been isolated from various parts of the plant. These findings are quite encouraging and suggest that this herb be researched further to validate these findings and uncover other possible therapeutic properties. Furthermore, the active chemical constituents of Wattakakka volubilis with significant pharmacological values must be isolated and...
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