Posted by admin on Feb 28, 2021 in |
Combretum mucronatum Schumach & Thonn is a scandent shrub whose leaves are widely used by Ghanaians and other West-African herbalists for the treatment of various infectious and non-infectious diseases. It is used to treat wounds, coughs, dysentery, worm infestation, neurological disorders and bacterial infections. Some coughs are as a result of mycobacterial infection. Despite the success gained in minimizing antibiotic resistance over the past decades, there still remains a need for new antibiotics. Due to the constant development of multi-drug-resistant bacteria to existing antibiotics, particularly those directed against multidrug-resistant Gram-negative bacteria such as the tuberculous bacteria, new antibiotics are needed. Folklorically used antimicrobial herbs are good sources of new antibiotics. In that regard, the aim of this study was to assess C. mucronatum leaves for its possible mycobactericidal activity and investigate its extracts phytochemically. The macroscopic, microscopic, and physicochemical characteristics were determined as preliminary means of quality assessment of the plant materials. Phytochemically, C. mucronatum is rich in a wide variety of tannins and flavonoids, and their corresponding TLC...
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Posted by admin on Feb 28, 2021 in |
Present study was aimed to search bioactive functional groups and compounds in the whole animal extract of a marine cnidarians Zoanthus sansibaricus by FT-IR and GC-MS. The methanol extract was used to detect bioactive functional groups and compounds. GC-MS of the animal extract was done, and FTIR analysis was thereafter used to identify the functional groups. The bioactive components were identified based on peak values in the region of infrared radiation. Results of GC-MS revealed eight major compounds like Undecane (13.16%), 2,6-Diisopropylnaphthalene (3.47%), Cyclohexasiloxane, dodecamethyl (6.33%), 6, 11-Undecadiene, 1-acetoxy-3, 7-dimethyl (2.84%), n-Hexadecanoic acid (19.91%), Triphenylphosphine oxide (4.34%), beta. -Sitosterol acetate (43.32%) and Dihydroartemisinin,6-deshydro-5-deshydroxin (6.64%). These are bioactive compounds may act as antimicrobial, antiviral, anti-inflammatory, and antioxidant agents. FT-IR analysis results also indicated the presence of functional groups like N-H (amide group), O-H (carboxylic acid and alcohol), C-H (carboxylic acid and alkanes), and C-F (alkyl halide group) in the...
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Posted by admin on Feb 28, 2021 in |
Antibiotic resistance could be a natural phenomenon that occurs when an antibiotic loses its ability to control or kill the bacterial growth; in other words, the bacteria become “resistant” and still continue to multiply in the presence of therapeutic levels of an antibiotic. Nano-technology is one of the foremost active areas in modern science. Nano particles exhibit a completely new or improved particle based on the specific characteristics. Plant extracts generally have excellent potential as antimicrobial compounds against microorganisms. Thus, they can be utilized in the treatment of infectious diseases caused by resistant microbes. The current study explores the phytochemical screening of aqueous extracts of Lantana camara, which had revealed the presence of flavonoids tannins, terpenoids, saponins, steroids, and alkaloids. Formation and stability of silver and gold nanoparticles in aqueous colloidal solution are confirmed using UV-Vis spectral, FTIR, XRD, SEM and EDX analysis. The antibacterial activity of crude, ethanol, and methanol extracts and plant-mediated silver and gold nanoparticles were done. The study concludes that the crude extracts showed the...
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Posted by admin on Jan 31, 2021 in |
The incidence of Inflammatory Bowel Disease (IBD) is now rising in developing countries and increasingly considered an emerging global disease. IBD is a chronic, intermittent disease. Symptoms of IBD varies from person to person and segment of the intestinal tract involved. IBD diagnosis depends on the various test, which requires blood testing, stool testing, endoscopy, biopsies as well as physical examination with patient history study. The most common side effects of antibiotics in the treatment of IBD are killing microflora with bacteria; hence it makes the condition worst rather than curing. Curcumin has many pharmacological such as anti-inflammatory, anti-oxidative stress, and anti-catabolic activity, which play an important role in mitigating in CD and UC in IBD. Monoammonium glycyrrhizinate (MAG) was recognized as a compound possessing antimicrobial properties, MAG tested many researchers using the agar diffusion method, which shows significant antibacterial activities against gram-positive (Bacillus subtilis, Staphylococcus aureus) as well as gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), MAG also decrease the permeability of intestine in IBD which inhibit autoimmune attack....
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Posted by admin on Jan 31, 2021 in |
Oregano oil is an essential oil possessing anti-inflammatory, antioxidant, antimicrobial, and immune-boosting properties that can be used in the treatment of various skin disorders. However, its practical applications are limited due to its handling issues and poor stability in the presence of air, light, and high temperature. To overcome these problems, this study aims to entrap oregano essential oil (OEO) in ethyl cellulose (EC) microsponges to get decreased dermal toxicity and enhanced stability. The quasi emulsion solvent diffusion method was utilized for fabrication of the OEO microsponges using EC as polymer, dichloromethane (DCM) as a solvent and polyvinyl alcohol (PVA) as stabilizer. The effect of formulation variables like stirring rate, stirring time and quantity of polymer were also examined. The prepared microsponges were evaluated for particle size and production yield. Results revealed that all microformulations were in the micro size range (19.87 mm to 248.13 mm), with a good production yield (72.85%) of M6. Spherical uniform shape with a spongy structure of microsponges was confirmed by Scanning Electron Microscopy...
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