Posted by admin on Dec 31, 2020 in |
The increasing public concern on the use of synthetic fungicide and resistance development led to an increase in search for alternative control strategies. Medicinal plants serve as therapeutic agents as well as important raw materials for the manufacture of traditional and modern medicine. Considering the vast potential of plants as sources for antimicrobial drugs with reference to antifungal agents, a systematic investigation was undertaken to explore the antifungal potential of few medicinal plants. In present study, in-vitro antifungal activities of few medicinal plant extracts were evaluated against two well-known plant pathogens i.e., Fusarium oxysporum (MTCC 284) and Cladosporium herbarum (MTCC 351). Fourteen plant ethanolic extracts were prepared, and out of them, five plants; Allium sativum, Zingiber officinale, Mentha spicata, Carica papaya and Elettaria cardamomum showed good antifungal activity. A. sativum ethanolic extract showing maximum antifungal activity was further subjected to carry out other studies. MIC values of ethanolic extract of A. sativum against F. oxysporum (MTCC 284) and C. herbarum (MTCC 351) were found to be 60 mg/ml and...
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Posted by admin on Dec 31, 2020 in |
Urolithiasis is one of the painful urologic disorders that occurs in approximately 12% of the global population. Syzygium jambos (L.) Alston (Family: Myrtaceae), commonly known as Rose apple in English and Bogijamun in the Assamese, is an important medicinal plant found extensively in Assam and in the Indian continent. Scientific studies confirmed that the extracts of various parts possess anticancer activity, antioxidant, analgesic, antimicrobial activities, and anti-inflammatory properties. Phytochemical and Pharmacological evaluation of the Plant was carried out with special reference to antiurolithiatic activity. The in -vitro evaluation was done using growth inhibition study of struvite crystals, and in-vivo evaluation was done by Ethylene glycol induced urolithiatic model in rats. Our investigation showed that leaf extracts and ZnO-NPs prevented the growth of urinary stones. Further studies should be done to understand pharmacological action and its possible mechanism through elaborate preclinical experimentation and clinical trials in preventing urolithiasis in susceptible...
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Posted by admin on Dec 31, 2020 in |
Benzthiazole, Chalcones, and their analogs have a wide variety of biological activities like antihelminthic, antifungal, antibacterial, anti-diabetic, anti-tubercular, anti-inflammatory, anticonvulsant, diuretic etc., In the present research work, an effort has been made to synthesize some new series of novel benzothiazole linked chalcones from 3-amino-acetophenone and potassium thiocyanate which were dissolved in glacial acetic acid at room temperature. Liquid bromine in glacial acetic acid was then added drop-wise, and finally, the reaction mass is quenched and basified with ammonia to obtain the desired Benzthiazole linked chalcone. The progress of the reaction is monitored through TLC. The purity of the compounds was identified by TLC and purified by recrystallization and column chromatography. The structures were determined by IR, 1H NMR, and Mass spectral data. The synthesized benthiazole linked chalcone analogues were screened for anti-tubercular activity by the use of MABA (Microplate Alamar Blue assay) analytical method on H37Rv strain of Mycobacterium tuberculosis. Based on the results of anti-tubercular activity, it can be seen that the compounds containing electron-withdrawing groups like chlorine,...
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Posted by admin on Dec 31, 2020 in |
The present study deals with the PHB made cast film with different plant and algal formulations. Its biocompatibility was tested in-vitro and in-vivo. The anti-inflammatory activity was higher in F4 and F5, close to the standard Diclofenac. The F7 and F8 exhibited moderate cytotoxicity, and formulation F2 exhibited low cytotoxicity. The maximum zone of inhibition was exhibited in F5 followed by F4 against skin pathogens. The overall results of antioxidant activity indicated that F4, F5, and F8 have good antioxidant properties. Percentage (%) of wound contraction at the 10th day of control was 16.9% and PHB alone was 21.3%. F5 and F3 showed higher activity with 51.7 and 49.7%, respectively. The self-healing potential was found to be 35.6%, but PHB was able to cure additional 5% (40.5) on 16th day. F5, F3, and F4 showed high activity of 81.5, 80.1, and 79.9, respectively. The in-vitro and in-vivo studies showed that the Centella asiatica and Padina tetrastromatica with PHB has an effective activity towards antimicrobial, antioxidant, and wound healing activity....
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Posted by admin on Dec 31, 2020 in |
The comparative toxicological characteristic in-vitro and antimicrobial activity to perform stability tests of several linear medium-chain aliphatic monoperoxyacids (perC8–C12) and aliphatic diperoxyacid (diperC9) were studied. Substances of peroxide acids: perС8, perС10, perС12, diperoxyazelaic acid (diperC9) are in 5.6; 22.8; 64 and 1.6 times less toxic than reference substance – peracetic acid (perC2). New knowledge concerning а comparative antimicrobial activity of studied medium-chain aliphatic peracids and their thermal sensitivity was obtained. These fundamental stability studies resulted in the emergence of safe antimicrobic agents. Nonanebis(peroxoic acid) and Peroxyoctanoic acid were proposed as an agent in the chemical disinfection prosses for the first time. Medium-chain aliphatic peracids were demonstrated to be very robust. Sufficiently high bactericidal activity was achieved after relatively short exposition times (from 10 min to 2 h for spores of B. anthracoid), at near-ambient temperature (20 °C). In this work, it has been demonstrated how stability studies can underpin rational design of antimicrobic agents that in turn lead to a both safer and economically viable chemical disinfection and sterilization...
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