Posted by admin on Jul 31, 2019 in |
A series of new Schiff bases were synthesized by condensation of 3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde with different aromatic aldehydes. The 3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde was prepared from 1-(1-(5-bromothiophen-2-yl)ethylidene)-2-(4-chlorophenyl)hydrazine by the Vilsmeier Haack reaction. The 1-(1-(5-bromothiophen-2-yl)ethylidene)-2-(4-chlorophenyl) hydrazine was prepared by the condensation reaction of 2-acetyl-5-bromothiophene with 4-chlorophynylhydrazine hydrochloride. The structures of newly synthesized compounds were elucidated by NMR, IR, and Mass spectral – data. Prepared Schiff bases were evaluated for antibacterial activity against four organisms: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae using streptomycin as a standard drug. Agar well-diffusion method was followed to determine the antimicrobial activity. All prepared Schiff bases showed poor to good activity against test organisms. Based on the zone of inhibition results, it is observed that the newly prepared Schiff bases showed better activity against Klebsiella pneumoniae than Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Schiff base 4c showed good activity against Pseudomonas aeruginosa, Schiff base 4l showed good activity against Staphylococcus aureus and all the Schiff bases 4a-4l except 4c showed good activities against Klebsiella...
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Posted by admin on Jul 31, 2019 in |
Boerhavia diffusa is a species of flowering plant in the four o’clock family, Boerhavia belongs to family Nyctaginaceae the plant holds the tremendous potential of medicinal value and has been traditionally used in various ailments like syphilis, leukoderma, blood disorders to name a few. The present study focuses on the GC-MS analysis of extracts of all the plant parts of B. diffusa which revealed the presence of certain bioactive compounds like kaempferol, luteolin, quercetin and so forth. A total of about 20 bioactive compounds were identified. In Boerhavia diffusa in all plant parts roots, stems and leaves kaempferol is observed maximum. Total amount of flavonoids was maximum in leaves and minimum in stem. Antimicrobial activity of the extracts was assayed against pathogenic bacteria and fungi. In B. diffusa, flavonoids extracted from leaf were highly active against F. oxysporium, against bacterial strains flavonoids from leaves were highly active and showed maximum activity against E. coli. The study thus infers that the presence of bioactive components may be the principle behind the...
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Posted by admin on Jul 31, 2019 in |
The genus Euphorbia has about 2000 members making it one of the largest ones among the flowering plants. Euphorbia helioscopia L. As the chemical composition of the essential oil from Euphorbia helioscopia developed in Egypt has not yet been explored, along these lines the present to extricate the essential oil and investigate the oil chemical composition and antimicrobial activity. Essential oil from the whole inflorescence of the flowering plant, Euphorbia helioscopia Linn. was extracted by hydrodistillation method. The chemical composition of the obtained volatile oil was investigated by GC-MS. The major components include thymol (48.36%), Caryophyllene (23.57%), carvacrol (6.70%), caffeic acid (6.48%) and caryophyllene oxide (5.58). Minor components as translongipinocarveol (2.77%) and DL-malic acid (1.9%). Screening antimicrobial activity of the isolated volatile oil against four bacteria showed that it was active only against Bacillus subtilis with an inhibition zone of 11 mm ± 0.25 and MIC value 17 mg /ml. Gentamycin was utilized as a positive antibacterial control. The data of this study might be considered as the first...
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Posted by admin on Jul 31, 2019 in |
One of the proposed groupings of the fluoroquinolones describes the excellent broad-spectrum activity forms an invaluable part of the present anti-infective armory of the clinicians. The fluoroquinolones are most significant weapons can be credited for saving more human lives than any other area of medicinal therapy. In this current research segment, the novel C-3 substituted fluoroquinolone scaffolds were designed, synthesized and elucidated by IR, H1NMR, and MS spectral data. The clinically banned drug gatifloxacin is acting as starting material used to obtain targeted compounds. The proposed scheme comprised of main cyclization by using phosphorous oxychloride, thiosemicarbazide, gatifloxacin. The former compounds were undergoing diazotization reaction followed by a coupling reaction with various tertiary amines. Further, all seven 3- substituted gatifloxacin derivatives (PGI-PGVII) were screened for antimicrobial and hypoglycemic activity. In the novel series of compounds PG III, PG IV, PG V exhibited good antimicrobial activity by inhibition of DNA gyrase enzyme whereas PG I, PG III, PG VI, PG VII were found to be the most active compounds with hypoglycemic...
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Posted by admin on Jun 30, 2019 in |
In the present investigation, the chalcone intermediates are synthesized by Claisen-Schmidt condensation reaction between acetanilide and appropriate aromatic aldehydes. Further, these chalcone intermediates were cyclized with phenylhydrazine in glacial acetic acid to give new pyrazolines derivatives using ultrasonic irradiation with higher yields in lesser time. All the synthesized derivatives are characterized by their TLC, Physical constant, FTIR, and 1H NMR. The Chalcone intermediates were screened for their antimicrobial activity while cyclized pyrazolines derivatives were screened in search of potential anti-inflammatory compounds. The compound 4c had shown good potential for anti-inflammatory...
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