Posted by admin on Oct 31, 2015 in |
Background: Hepatic encephalopathy (HE) is a brain dysfunction caused by liver insufficiency and/or portosystemic shunting. It is associated with poor survival and high risk of recurrence along with reduced quality of life (QOL) of patients and their caregivers. Nitazoxanide (NTZ) is an oral antimicrobial that improved mental status and QOL score in HE patients and is well-tolerated. Aim: To evaluate the efficacy and safety of NTZ compared to metronidazole and rifaximin in patients with grade II-III HE and to evaluate its effect on patients’ QOL. Patients and Methods: A Prospective, Randomized, Controlled, Open-Label, Pilot study. Thirty four patients were randomly assigned to receive either Nitazoxanide (n=12), Metronidazole (n=11) or Rifaximin (n=11) for 7 days. Serum ammonia level, Clinical Hepatic Encephalopathy Staging Scale (CHESS) and Chronic Liver Disease Questionnaire (CLDQ) for QOL was measured at baseline and at end of treatment. Results: Baseline and after 1 week serum ammonia levels and CHESS scores, showed no significant difference among the 3 groups. There was no significant difference in serum ammonia level...
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Posted by admin on Sep 30, 2015 in |
Nigella sativa (NS) is a commonly used herb in Asian and African countries. Extensive experimental studies have been done to shed light on its hepatoprotective, immunumodulator, antioxidant, antimicrobial and several other useful pharmacological properties. However, there is dearth of evidence to evaluate the effect of Nigella sativa extract in neuropathic pain. In this study we have used neuropathic pain model of Wistar rats using intraperitoneal cisplatin injection twice weekly for 4.5 weeks. Animals were divided into six groups of six rats each. Ethanolic extract of Nigella sativa, pregabalin, tramadol or combination of pregabalin and tramadol were given orally in Wistar rats in which neuropathy had been induced by cisplatin i.p. injections for 4.5 weeks. Single dose of drugs were given and pain assessment was done by soft touch, crude touch, Eddy’s hotplate and tail flick analgesiometer at 0, 30, 60, 90, 120 and 240 minutes. Nigella sativa showed significant analgesic effect on cisplatin induced neuropathic pain in all the experiments however pregabalin and tramadol showed better...
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Posted by admin on Sep 30, 2015 in |
Pyrazoline, among the various 5-membered heterocyclic compound derivatives has drawn attention towards it because of its various pharmacologically activities associated with it. Pyrazolines are a five membered heterocyclic having two adjacent nitrogen atoms within the ring with only one endocyclic double bond and is basic in nature. A lot of research work has been done on synthesis and biological activities of various pyrazoline derivatives over the years. Pyrazolines derivatives display tremendous biological activities such as antimicrobial, anti-inflammatory, analgesic, antipyretic, antidepressant, antitubercular, antiamoebic, anthelmintic, anticonvulsant, antihypertensive, antidiabetic, antitumor, anti-HIV, local anaesthetic, antioxidant, insecticidal, tranquilizing and receptor selective biological activity. The history of pyrazoline shows that it attracted many chemists to explore pyrazoline as a biologically active molecule. The study of biological evaluation of pyrazoline derivatives has been an interesting field of pharmaceutical chemistry. This review article focuses on the pharmacological profile of pyrazoline with various activities and examples in form of...
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Posted by admin on Aug 31, 2015 in |
A series of novel 2- substituted benzothiazole dithiomidocarbonate derivatives were synthesized by the reaction of 2-amino benzothiazole with various halides. The test compounds were screened for their antimicrobial activity (antibacterial and antifungal) by disc diffusion method and the results of the microbial activity indicates that the test compounds exhibited varying degree of antimicrobial activity. Among the substituents benzyl moiety exhibited the most potent activity and the compound Dibenzyl (1,3 benzothiazo-2yl) Dithioimidocarbonate(4T1) emerged as the most active antimicrobial agent and it is equipotent when compared to the reference standard Ciprofloxacin. Among the substituents propyl moiety exhibited the most potent activity and the compound Dipropyl (1,3 benzothiazo-2yl) Dithioimidocarbonate (4T3) emerged as the most active antifungal agent and it is equipotent when compared to the reference standard ...
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Posted by admin on Aug 31, 2015 in |
The present study depicts formulation and characterization of boric acid gel formulations. The formulated gels intervenes the advantages of gels along with higher and effective antimicrobial activity when compared to the formulations available in the market. The preparations were evaluated for different parameters as basic physico-chemical properties like physical appearance, texture, pH measurement, spreadability, viscosity and spectral analysis (UV-Visible and IR Spectroscopy) for its standardization. The sharp peak at 230nm was obtained in UV-Vis spectra. I.R spectra revealed that the boric acid binds extensively to the polymers. Antimicrobial activity of formulation was studied using Muller Hinton agar medium against E.coli MTCC 614 and S.aureus MTCC...
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