Posted by admin on Dec 1, 2014 in |
Fluoroquinoloes are a very important group of antibacterial agents that are widely prescribed for the treatment of infectious diseases in humans. These agents have excellent bioavailability and good tissue penetration with antimicrobial activity against pathogens especially resistance to other class of antimicrobial drugs. This article gives a comprehensive review on different aspects of fluoroquinolones such as discovery, structural modifications, pharmacokinetic properties, antibacterial activity, present status of important drugs in which pharmacists and medical microbiologists should be interested....
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Posted by admin on Dec 1, 2014 in |
Objective: Potato (Solanum tuberosum L.) is a major world food crop next in production to maize, rice and wheat. Potatoes are a source of dietary energy due to their carbohydrate level and also contain a high value of vitamins. The objective of this study was determine the phytochemical constituents and antimicrobial activities of four common potato varieties developed by CPRI (Central Potato Research Institute, Shimla, India) i.e. Kufri Bahar, Kufri Badshah, Kufri Pukhraj and Kufri Puskar. Methods: The antimicrobial activity of selected plant spices against the mentioned microorganisms and their effectiveness were assessed by the presence or absence of inhibition zones and zone diameter by using Agar well diffusion technique and some chemical tests were performed for analysis of phytochemical constituents. Results: The antimicrobial activity of all the potato extracts showed the significant inhibitory activity against all the bacteria and fungi strain. Conclusion: The demonstration of broad spectrum activity of potato varieties may help to discover new chemical classes of antibiotic substances that could serve as selective agents for...
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Posted by admin on Dec 1, 2014 in |
A number of trisubstituted 2-pyrazolines which are known for their biological importance like antimicrobial, anti-inflammatory, antitubercular, analgesic, anticancer, antimalarial, anti-viral, antihelmentic activities are prepared by reacting chalcones with phenyl hydrazine in absolute ethanol in presence of pyridine. In the present investigation an attempt has been made for the synthesis of 2-pyrazoline derivatives and subjected to molecular properties prediction by molinspiration, molsoft and osiris softwares. The synthesized compounds have been confirmed by IR, Mass and 1HNMR spectral data. These compounds were also screened for various biological activities like antifungal, anti-inflammatory and acute toxicity activity by standard methods. The synthesized compounds have shown moderate to good antifungal, anti-inflammatory activity and some of the synthesized compounds have shown significant activity as compared with standard. Compound 5d showed good antiinflammatory activity, compounds 5c, 5d, and 5e showed higher antifungal activity and all the synthesized compounds were found to be in conformity with lipinski’s...
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Posted by admin on Nov 1, 2014 in |
Antimicrobial effects of different extracts of lichens were evaluated in this study. Acetone extract of Heterodermia boryi have shown maximum inhibitory activity against Escherichia coli (22mm) followed by Staphylococcus aureus (21mm)and Pseudomonas fluorescenes (20 mm). Among fungi, diethyl ether extract gave desirable sensitivity pattern against Pestalotia foedans was very sensitive (21mm) followed by Paeciliomyces variotii (20mm). Most of the extracts of Sticta weigelii were found to be inactive against Fusarium oxysporum. Klebsiella pneumoniae was found to most resistant bacteria against Sticta weigelii. Among the tested microbial strains, Pseudomonas fluorescens was mostly inhibited (26 mm) by chloroform extract of Dermatocarpon vellereum. Serratia marcescens was found to be the most resistant strain against the lichen, but was effectively inhibited only by ethanolic extract of Dermatocarpon vellereum (20 mm). Hexane extract D. vellereum have shown maximum inhibitory activity against Staphylococcus aureus (23...
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Posted by admin on Nov 1, 2014 in |
Heterocylic chemistry have been known for many years but in recent years heteocyclics received great attention. In heterocyclic chemistry oxazoline is one of the most important moiety. Oxazoline moiety shows a wide range of application such as in agriculture industry, pharmaceutical, food industry, natural product, medicine, polymers and various other industries. Oxazoline moiety constitutes the core structure of many biologically active natural compounds. Oxazoline play a major role in medicinal chemistry. Heterocyclic compounds whose containing oxazoline moiety as core structure reported wide range of biological activities such as antibacterial, antifungal, antimicrobial, antioxidant, antipyretic, anti-HIV, anti malarial, anti tumour, anti viral, anti-inflammatory, CNS stimulant activity etc. Oxazolines synthesized by the reaction of various aromatic substitutes like acids, aldehydes, nitriles, azides etc. Synthetic chemist do great work on the synthesis and application part of oxazolines. In this review we have described various synthetic methodologies and their different biological activities reported by organic synthetic...
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