Posted by admin on Apr 1, 2014 in |
Metal complexes having two or more different metal ions not only possess excellent catalytic applications but also have many biological activities. In the present work, some ligand tartarate based mixed transition metal complexes of type [MxMI1-x (C4H4O6)]. XH2O [Where M and MI are Cu and Ni, and x= 0.2, 0.4, 0.6 and 0.8] have been successfully synthesized and were characterized by different sophisticated analytical techniques such as elemental analysis, FT-IR, TGA and XRD. From the analytical data; it was observed that all the complexes exhibited 1:1 (methyl: ligand) ratio. IR data shows that the ligand co-ordinates with metal ions in a bidentate manner through the two oxygen atoms. Thermal analysis shows the degradation pattern of the complexes. The synthesized metal complexes were then tested in vitro for biological activities against Bacillus subtilis, Staphylococcus Aureus, and Escherichia coli to assess their antibacterial and antifungal effect. Some of them showed promising antimicrobial...
Read More
Posted by admin on Apr 1, 2014 in |
Spondias pinnata is a well-known plant indigenous to South East Asian countries. The plant has been used intensively in many traditional herbal medicines across the globe. This plant has been known to possess antimicrobial, anti-diabetic, ulcer-protective, anti-cancerous, anti-diarrhoeal, anthelmintic, cytotoxic and hepatoprotective activity. It has also been reported that different parts of the plant is used as anti-thirst, anti-emetic and as an anti-tubercular agent. It owes its different pharmacological activities to the wide range of phytoconstituents that are present in the plant. The plant is found to contain sterols, flavonoids, polysaccharides and gums. β-amyrin, oleanolic acid and amino acids—glycine, cystine, serine, alanine and leucine, daucosterol, cycloartanone 24-methylene and lignoceric acid, ellagitannins, galloylgeranin, lignoseric acid and β –carotein are the other constituents that are found to be present in the plant. An attempt has been made to compile these phytoconstituents studies and the different ethnomedicinal and pharmacological properties of Spondias pinnata and provide a full-fledged review in a single document. This review emphasizes the need for more extensive research and...
Read More
Posted by admin on Apr 1, 2014 in |
Niosomes, an emerging class of novel vesicular systems, are non-ionic surfactant vesicles which can entrap both hydrophilic and lipophilic drugs. Niosomes are incorporated into in situ gels for sustained release of drug and to prolong the residence time. The aim of present study is to formulate and evaluate ocular niosomal in situ gels of Linezolid. Linezolid is a potent synthetic oxazolidinone derivative active against a broad range of gram positive and gram-negative aerobic and anaerobic bacteria. Niosomes were prepared using various surfactants (span 20, span 40, span 60 and span 80) in different ratios using thin film hydration technique. They were evaluated for particle size, entrapment efficiency and in vitro drug release. Niosomes prepared using cholesterol and span 60 in the ratio 1:2 showed higher entrapment efficiency and better in vitro drug release. The optimized formulation was formulated as in situ gels using Carbopol 971P and HPMC K4M in different ratios and evaluated for gelling capacity, pH, viscosity, in vitro drug release, drug content, antimicrobial activity and ocular irritation...
Read More
Posted by admin on Mar 1, 2014 in |
Cephalexin remain as one of the most versatile class of compounds against microbes and therefore, are useful substructures for further molecular exploration. A novel series of Schiff bases of cephalexin were synthesized. Thus condensation of 5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid, 7-[(amino phenyl acetyl) amino]-3-methyl-8-oxo, monohydrate with appropriate aldehydes afforded the Schiff bases. The purity of the compounds was determined by TLC. With elemental analysis and spectral data the structure of the synthesized compounds were elucidated. All the synthesized compounds were subjected for the screening of antimicrobial activity against 3 bacteria and two pathogenic fungi. Most of the synthesized compounds were found to possess moderate antibacterial and antifungal...
Read More
Posted by admin on Mar 1, 2014 in |
The chemistry of β-lactams has taken an prestigious place in organic and medicinal chemistry so the review on recent methods in the synthesis of 2-Azetidinone derivatives rendered as a lead molecule for designing potential bioactive agents and it accompanying additional various synthetic information and its orientations would encompass great deal of help to researchers, chemists and pharmacologists to make it the best, most productive, economical and medicinal important compounds which will be expected to show potent pharmacological activities. In future it would be useful to design different new drugs to bring in the market by using rapid, operationally simple, efficient and green procedure. This has led to the discovery of a wide variety of compounds that are of high interest from the point of view antibacterial, anti-inflammatory, antihyperlipidemic, CNS activity, anticancer, antimicrobial, pesticidal, cytotoxic, antidiabetic, antitumor, antifungal, antitubercular...
Read More
