Posted by admin on Jan 1, 2011 in |
In the present study, eight organic solvents and aqueous extracts of Canavalia mollis leaves were screened for their phytochemical composition, anti bacterial and free radical scavenging activities. Among the different extracts tested, ethanol, methanol and acetone extracts showed significant antimicrobial and radical scavenging activities. The most susceptible microorganisms were found to be Escherichia coli, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, and Streptococcus faecalis. Preliminary phytochemical analysis of the leaf extracts revealed that the antibacterial and the radical scavenging activities are mainly due to the presence of the phenolic compounds especially alkaloids. The results obtained suggest that C. mollis could be exploited in the infections management of various...
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Posted by admin on Jan 1, 2011 in |
Nigella sativa L. (Black cumin) has showed a broad spectrum of pharmacological effects like antipyretic, analgesic, anti-inflammatory and antimicrobial. These activities may be related to the seeds oil. The most important chemical composition of hexanic extract of seeds was unsaturated fatty acids and essential oil. In this investigation the hexanic extract of seeds was topically applied to evaluate the healing efficiency of seeds oil on the second degree burn wound models in rats. Animal were randomly divided into three groups of six for each group. Silver sulfadiazine was applied as an antiseptic standard drug. Wound healing was assessed by the rate of contraction and histological characteristics in treated and untreated groups. On day 12, the extract-treated animals showed 81.20% reduction in the wound area and were significantly (P<0.05) more than control group 63.31%. Histological study showed fully grown regenerated epidermis on day 12 in treated rats. The present study suggests the burn wound healing action of seeds may be due to anti-inflammatory, antioxidant and antimicrobial activities of major compounds...
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Posted by admin on Dec 1, 2010 in |
Calotropis procera (Asclepiadaceae) is an erect, perennial shrub luxuriantly thriving in wastelands. It is commonly distributed in most parts of India and also distributed in Persia, tropical Africa and other tropical countries of the World. The aqueous extract of some parts have laxative property and beneficial in skin diseases, ulcers, enlargement of the spleen, abdominal glands, liver diseases, promotes digestive power and also useful in colics. The milky exudate is useful in skin diseases, tumour and ascitis. It is a very good purgative. Here an attempt has been taken to evaluate the antioxidant activity, CNS depressant activity and also antimicrobial activity of methanolic extract of fresh flowers of C. procera. In result, the methanolic flower extract showed a significant activity against DPPH free radicals and the IC50 value is 64.87µg/ml. On the other hand, CNS depressant activity of the extract was also observed by using In Vivo model. In antimicrobial activity five different fungal species were inhibited by this extract and from the above study the flowers extract showed...
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Posted by admin on Dec 1, 2010 in |
Antibiotics have a well-documented efficacy in the treatment of established infections and as prophylactic agents in medically compromised patients. Antibiotics use is suggested to be a major risk factor for development of antibiotic resistance. Resistance to antimicrobials is emerging at an alarming rate that has reduced treatment options for nearly every pathogen infecting humans. Many bacteria now display a variety of mechanisms that help protect them during antimicrobial exposure. These include production of β-lactamases and cephalosporinases, alterations in penicillin-binding proteins, multidrug efflux pumps, transferable resistance to vancomycin, and mutations in genes encoding DNA gyrase. This article gives information about how bacteria develop antibiotic resistance, new era of antimicrobial therapeutics and new strategies to eliminate antibiotic...
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Posted by admin on Sep 1, 2010 in |
Objective: To evaluate the antibacterial activity of ethanolic extract of roots of Vetiveria zizanioides. Method: Ethanolic extract of roots of Vetiveria Zizanioides was prepared. Standard cultures of Escherichia coli NCIM 2118; Bacillus subtilis NCIM 2063, P. aeurogenosa NCIM 2036 and Staphylococcus aureus NCIM 2079 were used for the study. The antibacterial tests used were the agar well plate method. Ciprofloxacin was used as the positive control. Results: EEVZ does not show any activity against B.subtilis. However, the activity was less than the standard Ciprofloxacin. The extract shows increasing inhibitory activity with increase in concentration (150-750µg). Conclusions: From our investigation, for screening ethanolic extract of Vetiveria zizanioides the results obtained confirmed therapeutic potency of some plants used in traditional medicine. The plants could be potential source of new antimicrobial...
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