Posted by admin on Feb 25, 2015 in |
The complexes of Ru(III) having general formula [Ru(L)Cl(PPh3)] where L= azo Schiff base derived from 2-aminopyridine, 2-hydroxy naphthaldehyde /vanillin and ethylene diamine have been synthesized. The ligands as well as complexes have been characterized by elemental analysis, molar conductance, magnetic susceptibility, infra-red and electronic spectral data. The azo Schiff base ligand acts as a tetradentate ligand co-ordinating to Ru through azomethine nitrogen and phenolic oxygen atoms. An octahedral geometry has been proposed for the complexes based on electronic spectra and magnetic susceptibility studies. Low molar conductance values revealed the non-electrolytic nature of the complexes. The complexes have been screened for antimicrobial and anticancer...
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Posted by admin on Feb 25, 2015 in |
Complexes of Co(II) with macrocylic ligands i.e., 2, 3, 9, 10 tetraphenyl – 1, 4, 8, 11 – tetraazacyclotetradeca – 1, 3, 8, 10 tetraene (BDP), 2, 4, 10, 12 – tetramethyl – 1, 5, 9, 13 tetraazacyclohexadeca 1, 4, 9, 12 tetraene (ADP), 2, 3, 9, 10 tetramethyl 1, 4, 8, 11 tatraazatetredeca – 1, 3, 8, 10 tetraene (DDP) have been synthesized. All these complexes were characterized by elemental analysis, molar conductance magnetic susceptibility measurement, electronic and epr spectral studies. On the basis of elemental analysis the complexes were found to have composition CoLX2. Molar conductance measured in DMF solution indicates that complexes are non-electrolytic in nature except Co(BDP)SO4 which are 1 : 2 electrolytes. Thus the complexes may be formulated as [CoCLX2]. Magnetic moments and the electronic spectra indicate six coordinated distorted octahedral geometry for the complexes. The ligand field parameters were calculated using various energy level diagrams. In vitro synthesized compounds and metal salts have also been tested against same species of plant pathogenic fungi...
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Posted by admin on Feb 25, 2015 in |
Plants in Combretaceae family are traditionally reputed to be anthelmintics and antimicrobial agents. Dried aerial parts of Combretum sordidum (Exell) were ground to fine powder and extracted using ethanol. Ethanol extract was partitioned to obtain hexane and ethylacetate extracts successively. These extracts were screened for secondary metabolites using standard methods and evaluated for their antimicrobial potentials against two Gram positive bacteria; Bacillus subtilis (ATCC 14579) and Bacillus cereus (ATCC 33923); two Gram negative bacteria; Proteus mirabilis (ATCC 21784), Salmonella typhi (ATCC 25179) and a fungus; Candida albicans (NCTC 227) by tube dilution method. Essential oil from its leaves was obtained by hydrodistillation method and analyzed by GC and GC-MS. Preliminary phytochemical screening revealed the presence of alkaloids, saponins, tannins, flavonoids, cardiac glycosides, steroids and anthraquinones in the ethylacetate and ethanol extracts. Both extracts displayed broad spectrum activities against the organisms used with minium inhibitory concentration (MIC) at 400µg/mL. Five compounds comprising 99.99% of the total peak area were identified from the volatile oil. The most abundant constituent was 7-...
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Posted by admin on Feb 25, 2015 in |
The Antimicrobial (antifungal and antibacterial) properties of the different solvents extracts (benzene, pet ether, acetone, chloroform, methanol and aqueous) of Rumex vesicarius Linn plant plants, on four bacterial (Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus) and four fungal isolates (Aspergillus niger, Tricoderma reesei, Penicillium funiculosum and Fusarium oxysporum) were investigated by well diffusion assay. The minimum inhibitory concentration (MIC) of these solvents extracts evaluated at different concentration (3.25 mg/ml, 6.25 mg/ml, 12.5 mg/ml, 25 mg/ml and 50 mg/ml) for the tested organisms. The widest spectrum of antimicrobial activity was recorded for pet ether extract of leaf against P. funiculosum (30±1.2mm), F. oxysporum (22±0.8mm), E. coli(20±0.9mm) and P. Aeruginosa (10±0.7mm). This was followed by the benzene extract of leaf, which inhibits P. funiculosume t4l(20±0.8mm), F. oxysporum (18±0.4mm), E.coli(10±0.7mm). Acetone extract of flower work against P. funiculosum (30±1.4mm), A. niger, (12±0.7mm), E. coli(20±0.6mm) and S.aureus (18±0.8mm). The inhibitory effect of chloroform extract of flower against A.niger, (18±0.3mm) and F. oxysporum (16±0.3mm). The antimicrobial activity of methanolic and aqueous extract...
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Posted by admin on Jan 31, 2015 in |
The present investigation is concerned with synthesis of new substituted benzoxazolinone derivatives (1-18) with the objective of discovering novel and potent antimicrobial agents. The structure of all the synthesized compounds were elucidated by elemental (C, H, N) and spectral (IR, 1HNMR and mass) analysis. The purity of the synthesized compounds was checked by thin layer chromatography (TLC). The obtained compounds were screened for their antibacterial as well as antifungal activities and compared with reference drugs ciprofloxacin and fluconazole respectively. All the newly synthesized compounds were screened for their antibacterial activity against S. aureus, E. coli, K. pneumoniae and antifungal activity against A. niger, C. albicans. Compounds 13 and 18 were found to be the most potent members of the present series; they showed maxium antibacterial and antifungal properties much better than the standard drug. The compounds 15, 16 and 17 exhibited good antibacterial activity as well as while antifungal...
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