Posted by admin on Dec 1, 2012 in |
Aim of this study was to determine the Antimicrobial, Cytotoxicity and Antioxidant activities of the stem of Ravenia spectabilis. For this study, the dried stem’s powder of Ravenia spectabilis was subjected to cold extraction with methanol and partitioned with n-hexane, carbon tetrachloride and chloroform. The crude methanolic extracts and its n-hexane, carbon tetrachloride, chloroform soluble partitionates, some column fractions and isolated one pure compound (g-fagarine) demonstrated mild to moderate antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria and fungi. The extractives showed significant cytotoxic activity when tested by brine shrimp lethality bioassay. In addition, the extractives also exhibited significant free radical scavenging activity when compared with the standard drug Tert– butyl-1-hydroxytoluene...
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Posted by admin on Dec 1, 2012 in |
The antimicrobial activity of the extracts Basella alba fruit were evaluated by measuring the zones of inhibition using Agar well Diffusion method against eight species of microorganisms: Bacillus subtilus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Lactobacillus, Klubsiella, Aspergillus niger and Aspergillus fumigatus. The extract showed significant antibacterial activity against Lactobacillus and antifungal activity against Aspergillus fumigates, no activity was found against Klebsiella and moderate activity was observed for all other tested organism. The minimum inhibitory concentration of the extract against bacterial strains was found to be 25mg/ml for Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Lactobacillus, Escherichia coli, Aspergillus niger and Aspergillus fumigates and 50mg/ml for Klebsiella pneumonia. The overall result of this study indicates that the extract from Basella alba fruit have interesting antimicrobial property and thus provide justification for the use of the plants in folk medicine to treat various infectious...
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Posted by admin on Dec 1, 2012 in |
Pyrimidine is a six membered cyclic compound containing 4 carbon and 2 nitrogen atoms and is pharmacologically inactive but its synthetic derivatives possess an important role in modern medicine. Pyrimidines and their derivatives are considered to be important for drugs and agricultural chemicals. Pyrimidine derivatives possess several interesting biological activities such as antimicrobial, antitumor and antihypertensive activities. Many pyrimidine derivatives are used for thyroid drugs and leukemia. The biological significance of the pyrimidine derivatives has promoted us to synthesize some new substituted dihydropyrimidines, and evaluate them for their anti-microbial activity. The titled compounds were identified and characterized by IR and 1HNMR...
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Posted by admin on Dec 1, 2012 in |
The present study was undertaken to evaluate antioxidant, cytotoxic and antimicrobial activity of Sonneratia alba bark. The carbon tetrachloride, chloroform soluble partitionate of methanolic extract and crude methanolic extract showed significant antioxidant property using 1,1-diphenyl-2-pecrylhydrazyl(DPPH) scavenging assay ,of which chloroform partitionate and crude extract demonstrated highest activity with IC50 value of 12µg/ml and 14µg/ml respectively. In the brine shrimp lethality bioassay, LC50 values obtained from the best fit line slope were 0.812, 14.94, 0.831 and 3.288 µg/ml for standard (Vincristine sulphate), n-Hexane, carbon tetrachloride and chloroform soluble partitionate of methanolic extract respectively. The carbon tetrachloride soluble fraction revealed moderate activities against Bacillus cereus, Bacillus subtilis, Sarcina lutea, Pseudomonas aeruginosa and Shigella dysenteriae test...
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Posted by admin on Dec 1, 2012 in |
Antimicrobial activity of compound (2) was investigated against pathogenic microorganisms: Staphylococcus aureus (Gram (+), Escherichia coli (Gram (-) and fungal strain, Candida albicans using the Well Diffusion and the Poison plate methods. Compound (2) was shown to inhibit pathogenic growth, and judging from the area of the zone of inhibition, the susceptibility of the microorganism against compound (2) follows the sequence: Staphylococcus aureus > Candida albicans > Escherichia coli. The area of zone of inhibition ranging from (4.64 mm2 to 6.47 mm2) and (4.64mm2 to 5.72 mm2) for the Well Diffusion and Poison plates respectively. Both methods indicate that the area of the zone of inhibition for compound (2) is more potent than reference antibiotics: Nystatin and...
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