Posted by admin on Jul 31, 2014 in |
Probiotics are live microorganisms, which when administered in adequate amounts confer a health benefit. There are very limited studies on antidiabetic effect of lactic acid bacteria despite their potentiality in reducing the risk of diabetes onset. The present study explored the effect of administering live culture of L. rhamnosus [MTCC No 8712] and L. casei [MTCC No 1408] in STZ induced diabetic albino male rats. Animals (approximately aged 6 months) were grouped into three in a randomized fashion that average weight of animals in each group would be 150-250 gms. Normal feed pellets and water ad libitum were provided to animals throughout the experiment. As Group 1-Control Group, Group 2-Positive control Group were on only insulin treatment (1 unit /day) and the Group 3-Treated Group were on probiotics treatment.The treatment was continued for 30days. Body weight, blood glucose, lipid profile, antioxidative status was analyzed by standard protocol. After subculturing L. rhamnosus and L. casei and standardizing with Mac Ferlan’s device, the mixture culture was administered to the treatment group...
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Posted by admin on Jun 1, 2014 in |
The present study was carried out to investigate the effects of oral administration of aqueous extracts of Cleome rutidosperma leavesand Senecio biafrae roots on blood glucose, biochemical parameters, lipid profile, antioxidant enzymes activity and hepatic glucose regulating enzyme activities in Streptozotocin (STZ)-induced diabetic rats. STZ was administered as a single dose (60mg/kg wt, i.p.) to induce diabetes. The effects of the extracts were compared with the standard drug Glibenclamide (600μg/kg b.wt). The aqueous extract of both plants at different doses (125mg/Kg, 250mg/Kg and 500mg/Kg) administered orally to the diabetic rats for 28 days, produced significant (p < 0.05) decrease in the level of blood glucose, feed and water intake as well as serum cholesterol, triacylglycerols, low density lipoprotein (LDL), creatinine, urea, bilirubin and activity of liver marker enzymes such as AST, ALT, ALP and TBARS in liver and kidney. Treatment also produced significant (p < 0.05) increase in body weight, PCV, High density lipoprotein (HDL), Superoxide dismutase (SOD), Catalase (CAT), Glutathione-S-Transferase (GST) and Glutathione Reductase(GR). Administration of both extracts...
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Posted by admin on Feb 1, 2014 in |
Energy drinks (EDs) are caffeine-based beverages that commonly contains large amount of carbohydrates, sugar, health supplements and various energy stimulants, such as ginseng and vitamin B, to name a few. These drinks are marketed for young people actively involved in sports or overworking hours, as natural alternatives that increases fun and improve physical and cognitive performances such as attention, concentration and alertness. There are commonly held false perceptions that the consumption of EDs can rectify the impairment to human physiology because of alcohol consumption including visual reaction time and motor coordination, which is highly required for sports and driving activities, to name a few. The sensory analysis was done in the form of survey. The statistical analysis was done using SPSS software and Analysis of Variance (ANOVA). The graph was obtained between feedbacks (given by the candidates) and number of people for different sensory properties like smell, taste, flavour, texture, and...
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Posted by admin on Feb 1, 2013 in |
Decrease in blood glucose level test with the use of oral glucose tolerance method from Avocado leaves was carried out. Swiss Webster male mice were divided randomly into five groups. They were negative control, positive control (Glipizide 0.013 mg/20 g BW) and three test groups treated with dosage of avocado leaves ethanol extract 0.490 g/kg, 0.980 g/kg and 1.960 g /BW respectively. Experiment was begun with feeding the mice with the test solution followed by feeding glucose solution (1.5 g/kg BW) 30 minutes later. Blood glucose levels were assessed using glucometer kit, from zero to 3 hours, at ½ hourly interval. These results analysed by one way ANOVA showed there were significant difference (p<0.05) between Ethanol extract of avocado leaves treated with mice (0.490, 0.980 g/kg BW) and control groups.Furthermore, when Tukey’s test was performed, avocado treated mice (1.960g/kg BW) reduce glucose level to 64.27%. The effectiveness of this treatment was not significantly different to those treated with glipizide...
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Posted by admin on Dec 1, 2012 in |
Melt extrusion process which is well known in the polymer and food industry is now being used for pharmaceutical manufacturing to create innovative new formulations and is a continuous process of mixing and designing moldable materials. It is one of the most widely applied processing techniques useful for preparing solid dosage forms, granules, pellets, suppositories, implants, stents, ophthalmic inserts, transdermal and transmucosal drug delivery systems. Also this technique is used in Taste Masking, Solubility Enhancement, and Sustained-Release Pellets Manufacturing. Several advantages over other techniques include cost and performance benefits such as a faster path to FDA approval for new compounds, possible re-indication for existing active pharmaceutical ingredient (APIs), controllable bioavailability, possible lower doses, and probable lower production costs. Hot-melt extrusion efficiently produces solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. In general, high temperatures have to be applied to extrude polymeric carriers. Melt extruded dosage forms are complex mixtures of API, excipients, and polymer carrier which are blended using single and twin-screw...
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