Posted by admin on Jan 1, 2013 in |
Lamivudine, a BCS Class I synthetic nucleoside analogue, has a a short biological half-life of 5–7 and is mainly absorbed in the upper gastrointestinal tract. The purpose of the study is to develop a controlled release floating tablets of lamivudine employing HPMC K4M and sodium alginate. The floating tablets of lamivudine were prepared employing HPMC K4M and sodium alginate as matrix formers and sodium bicarbonate as an effervescent agent. The tablets formulated were evaluated for tablet weight variation, drug content uniformity, hardness, friability, floating behaviour and in-vitro drug release. All the formulations fulfilled the official requirements for tablet weight variation, drug content uniformity, hardness and friability. Tablets formulated by using a combination of HPMC K4M/sodium alginate and HPMC K4M alone gave a lesser floating lag time when compared with tablet formulated with sodium alginate alone. All the tablets were found to remain buoyant in 0.1N HCl for a period >24h. The drug release from the prepared tablets was found to be diffusion controlled and followed first order kinetics. Non-Fickian...
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Posted by admin on Jan 1, 2013 in |
Diclofenac Potassium, a sparingly soluble non-steroidal anti-inflammatory drug, was taken as candidate for decreasing the onset of action time and increasing its bioavailability by overcoming its first pass metabolism. Diclofenac Potassium orally disintegrating tablet (ODT) formulations were developed using lyophilization technique. The freeze dried tablet formulations were prepared by freeze-drying an aqueous solution of Diclofenac Potassium, matrix former, filler, and an anti-collapse. The tablets were evaluated from both compendial and non-compendial criteria (i.e. uniformity of weight, uniformity of content, friability, in vitro disintegration time, in vitro dissolution, wetting time, in vivo disintegration time, moisture analysis and scanning electron microscopy. The best formula results showed that lyophilized ODT disintegrated within few seconds and showed significantly faster in-vitro dissolution rate of Diclofenac Potassium in comparison with commercially available immediate release tablet Diclofenac Potassium tablet (Cataflam®). The in-vivo evaluation for the best formulation (LD#11) was performed in comparison with the immediate release tablet Diclofenac Potassium tablet (Cataflam® 50 mg). A randomized crossover design was adopted in the comparative bioavailability study and was...
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Posted by admin on Nov 1, 2012 in |
Objectives: To assess the effect of unripe dried banana powder in experimentally induced gastric ulcers and effect on gastric acid secretion. To evaluate the antiulcerogenic effect of plantain banana of Gujarat as a part of evaluation of impact of biological variables on this activity. Results: Orally administered banana powder in the dose of 2gm/kg caused a statistically significant decrease in aspirin with pyloric ligation induced ulcers in rats without significantly decrease in secretary activity.Materials and methods: Total of 24 albino rats of either sex weighing between 150-250 gm were randomly divided into 4 groups. Each group has 6 no. of rats. The first group received placebo (distilled water), the second, third & forth group received 0.5gm/kg, 1gm/kg and 2mg/kg of banana powder respectively. Banana powder was given as suspension at fixed time (3 times in a day) for two days and animals were kept for fasting for another 48hrs. On 5th day, the animals were sacrificed after 7 hrs and stomach were removed for examination and gastric juice samples...
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Posted by admin on Oct 1, 2012 in |
A complete documentation of the ethno-biological information presently existing among the diverse communities is needed at an earliest so as to restore the traditional medicinal knowledge. Research to find out scientific evidence for claims by tribal healers on Indian herbs has been intensified as being evidenced from many cited literatures. Once these local ethno medical preparations are scientifically evaluated and disseminated properly, people will be better informed regarding efficacious drug treatment and improved health status. Hence, the plant, Mimosa pudica Linn. was selected for the present study based on its medicinal use in the locality. Successive solvent extraction of the root powder of M. pudica was carried out as per the standard procedure using various solvents like, petroleum ether (40o-60oC), ethyl acetate and methanol. Preliminary phytochemical analysis, isolation of metabolites and antimicrobial activities of the extracts as well as the first time reported isolates were carried out. Preliminary phytochemical studies of vaious solvent extracts revealed presence of many biologically important secondary metabolites, such as, alkaloids, steroids, phenolic compounds, tannins,...
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Posted by admin on Apr 1, 2012 in |
Euphorbia prostrata Ait.(Euphorbiaceae) is a small, prostrate, annual green herb sometime purple tint in colour. It is widely distributed globally and used as antihemorrhoidal, anti-inflammatory, analgesic, hypolipidemic, antidiabetic, antidirroheal, antiasthmatic and for various skin diseases. The microscopy of root shows the presence of obliterated cork cells, phelloderm, cortex, endodermis, phloem, medulary rays and xylem; the stem shows the presence of multicellular trichome, cuticle, epidermis, cortex, endodermis, pericycle, phloem, latex canal, xylem and pith; the leave reveal the presence of multicellular, multiseriate glandular hairs, epidermis, vascular bundles, stomata anomocytic and anisocytic. The vein islet number and vein termination number have also been determined. The powder study reveals the presence of epidermal cells, trichomes, parenchymatous cells, pollen grains, vessels, fibers and stomata. The water soluble, alcohol soluble and petroleum ether extractive values were determined. The total ash, water soluble ash, acid insoluble ash and sulphated ash were also observed. Preliminary phytochemical studies revealed the presence of flavonoids, tannins, glycosides and saponins in the alcoholic extract of the plant. This is the...
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