SATURATION SOLUBILITY OF SCOPOLAMINE IN THIN FILMS OF POLYACRYLATE PRESSURE SENSITIVE ADHESIVES IS TEMPERATURE DEPENDENT
The method of drug uptake from solid solution has been used to measure the saturation solubility of scopolamine base in various pressure sensitive adhesive DURO-TAKs at elevated temperature. The saturation solubility was strongly temperature dependent, being 50 – 100 % larger at 45°C than at 25°C. The higher temperature also caused much more rapid approach to equilibrium distribution of the dr...
The plant Hugonia mystax L., is a woody evergreen liana belonging to the family Linaceae, locally knows as Modirakanni. Ethnobotanically the tender fruits were used for rheumatism and biological activities like antimicrobial were reported. Present study find outs the scientifically evidence of fruits of Hugonia mystax for its antioxidant property. The different extract of fruits was obtained by su...
SYNTHESIS AND CHARACTERIZATION OF NOVEL CHOLESTERYL LACTATE BASED FATTY ACID ANALOGS AND THEIR IN VITRO ANTIMICROBIAL ACTIVITY
A series of novel cholesteryl lactate-fatty acid conjugates (4a-i) were prepared by esterification of cholesterol with lactic acid, followed by coupling hydroxyl group of cholesteryl lactate with –COOH group of fatty acids including, saturated fatty acids of varying carbon chain of C10-C18, unsaturated fatty acids like 10-undecenoic, oleic ((9Z)-octadec-9-enoic), ricinoleic ((9Z,12R)-12-hydroxyo...
Impacts of sodium and potassium in diet to determine offspring gender in hamsters have been investigated. Sex determination has scientific basis for prevention of genetic diseases in addition to social backgrounds.20 healthy hamsters chosen from the first generation of the previous experimental hamsters, were divided in to two groups in the hamsters male to female 1:5. The first group was Na and...
The use of nanoparticles as drug delivery and targeting agents has led to immense progress in the field of biomedicine and diagnostics. Likewise gold nanoparticles can be conjugated with various molecules, for instance, to plasmid DNA for gene therapy, to various drugs for antibacterial and anticancer properties, to several antibiotics and peptides for immunological and diagnostic purposes. The re...
SIMULTANEOUS ESTIMATION OF RABEPRAZOLE SODIUM AND CINITAPRIDE HYDROGEN TARTRATE IN COMBINED PHARMACEUTICAL FORMULATION
Three simple, rapid, precise and accurate spectrophotometric methods have been developed for simultaneous analysis of Cinitapride Hydrogen Tartrate (CNT) and Rabeprazole Sodium (RAB) in their combined dosage form. Method A, Simultaneous equation method (Vierodt’s method) applies measurement of absorptivities at two wavelengths, 265.6 nm (λmax of Cinitapride Hydrogen Tartrate) and 282.6 nm, (λm...
COMPARISON OF ANALGESIC EFFECT OF EPIDURAL ROPIVACAINE (0.2%) AND ROPIVACAINE (0.2%) WITH FENTANYL (4mcg/ml) IN POST OPERATIVE PATIENT OF TOTAL KNEE REPLACEMENT SURGERY
Introduction: Epidural anesthesia is the most commonly used technique for providing not only peri-operative surgical anesthesia but post-operative analgesia in lower abdominal and limb surgeries. Our study aimed to assess the comparison between ropivacaine(Group A) and combination of ropivacaine with fentanyl (Group B) in terms of their analgesic effect, hemodynamic stability, side effects and req...
Background: In present study, we aim to assess the anticandidal activity of crude extracts and screening of bioactive compounds and their identification by NMR, IR and GC-MS. Results: A total of 192 isolates were isolated from patients having oral and vaginal candidiasis and a total of 134 isolates showed positive results with Gram staining. The selected isolates APKU-2, APKU-3 and APKU-4 were ide...
COMPARATIVE STUDY OF EFFECTS TWO β2 ADRENERGIC AGONISTS ON BIOCHEMICAL PARAMETERS IN MODERATE TO SEVERE BRONCHIAL ASTHMA PATIENTS
Background: β2- agonist drugs are frequently prescribed in asthmatics. Apart from bronchodilation they affect biochemical and physical parameters of the body. Method: Total 80 patients were divided into two groups. Group I (n=40) received Albuterol- 2.5mg./2.5ml. TDS and Group II (n=40) received Levalbuterol- 0.63mg./2.5ml, TDS via nebulizer for 4 weeks. Baseline and post-treatment estimatio...
PREVALENCE OF DIAGNOSED AND UNDIAGNOSED HYPERTENSION IN A RURAL COMMUNITY: A HOME BASED SCREENING STUDY
Background: Hypertension is one of the global risks for mortality and is seen with drastic rise in developing nations with rise in age. Methods: This cross sectional study was conducted in Ottapalam town, Palakkad district, Kerala, India. Based on inclusion criteria (non-pregnant, age group between 35-75 years) 142 subjects were studied. Patient data (demographics, lifestyle factors, medical repor...