Guillain-Barré syndrome is a rare but important disease that can lead to life threatening respiratory failure. This review summarises the verified consideration of Guillain-Barré syndrome (GBS) which are thought to be caused by direct autoimmune attack on peripheral nerves. Aim- Nerve conduction study helps differentiate the heterogeneous subtypes of GBS. Patients exhibit a progressive paralysis...
CHARACTERISTIC AND OPTIMIZED USE OF BIOACTIVE COMPOUNDS FROM GLORIOSA SUPERBA AND ALBIZIA AMARA WITH APOPTOTIC EFFECT ON HEPATIC AND SQUAMOUS SKIN CARCINOMA
Background: Cancer is still a dreadful disease, the treatment ranges with difficulties like strong side effects, shortage of donor and organs. In relation, plants and its chemical properties will provide an efficient source in the innocuous treatment for cancers. Objectives: To identify and isolate bioactive compounds from Gloriosa superba tubers and Albizia amara leaves with anti-cancer property ...
Carvedilol is used for hypertension, angina pectoris and in symptomatic heart failure. It has a short half life of 2h and bioavailability of 25%. Therefore the present investigation is concerned with the development of the buco-mucoadhesive films, which were designed to prolong the buccal residence time, to increase penetration through buccal mucosa and thus increase the bioavailability and its ha...
Background: Alcoholic liver disease is a spectrum of alcohol induced injury that includes fatty liver, alcoholic hepatitis and alcoholic cirrhosis. Corticosteroids are used in cases of severe alcoholic hepatitis with Maddrey’s Discriminant Function score > 32. However, many of the patients who are being managed by corticosteroids are non responders and mortality increases in such patients. Li...
Objective: To assess the pattern of adverse drug reactions (ADRs) in a tertiary care hospital. Materials and methods: This study was conducted in VSS Medical College, Burla, Odisha from October 2012 to September 2014. ADRs collected from various clinical departments were compiled and analyzed for distribution of age, gender, department, drug class and organ system. Assessment of causality, severit...
TRACE LEVEL QUANTIFICATION OF CYPIONYL CHLORIDE IN TESTOSTERONE CYPIONATE BY PRE COLUMN DERIVATIZATION WITH 2-BUTANOL BY GAS CHROMATOGRAPHY WITH ELECTRON IMPACT IONIZATION DETECTOR
The author has been proposed the precolumn derivatization method for the trace level quantification of cypionyl chloride in testosterone cypionate, it maybe potential impurity in the testosterone cypionate, it has to quantify in the testosterone drug Substance. The method development of cypionyl chloride has been started with gas chromatography with FID detector. The detection of cypionyl chloride...
STUDY ON SAFETY AND EFFICACY OF DIFFERENT MODALITIES IN THE POST-OPERATIVE PAIN MANAGEMENT IN A TERTIARY CARE TEACHING HOSPITAL
ABSTRACT: Background: Postoperative pain control is an important part of effective postoperative care. However, 30 - 80% of postoperative patients complain about moderate to severe post-surgical pain as a result of the surgical procedure or a pre-existing disease. Aim: To assess the safety and efficacy of different modalities of postoperative pain management in post surgical wards of a tertiary ca...
CLINICAL EVALUATION OF A NEW FORMULATION OF 99mTc-TRODAT-1 FOR SPECT IMAGING IN PARKINSON PATIENTS AND VOLUNTEER SUBJECTS
This study was conducted to evaluate the clinical usefulness of new developed kit of 99mTc-TRODAT-1 to differentiate PD(Parkinson disease) from volunteer subjects. The 925-1111MBq (25-30 mCi) 99mTc-TRODAT-1 samples were reconstituted by boiling water bath method. Fourteen subjects (women = 6, men = 8, age range 24 - 72, mean = 54.4) have been participated in this approach. The control group includ...
India is a land of medicinal flora, there are large numbers of plants with miraculous medicinal values has been used traditionally to cure several diseases from decades in Ayurveda. So the present study was designated to evaluate the antimicrobial activities of Aegle marmelos (bale) bark extracts. In this study different bark extracts were prepared using various solvents, further these extracts we...
Lymphatic Filariasis is one of the most abandoned tropical diseases caused by the parasite, Brugia malayi. The existing conventional drugs act generally on the larval stages of the parasite. The enzyme asparaginyl tRNA synthetase is an excellent molecular target as it plays a crucial role in protein synthesis. Evidences based on the literature presented clues to discover the flavonoids as potentia...