CHEMICAL PROFILING, ADME PREDICTION OF BOERHAVIA DIFFUSA LINN. AND CRATEVA NURVALA BUCH. HAM IN THE MANAGEMENT OF UROLITHIASIS
Background: This study was carried out to investigate qualitative and quantitative phytochemical analysis and free radical scavenging activity of Boerhavia diffusa (root) and Crateva nurvala (bark) along with certain computational ADME (Absorption, Distribution, Metabolism, Excretion) parameters of compounds analyzed from Boerhavia diffusa (root) and Crateva nurvala (bark). Methods: The dried powd...
Present work has been conducted to evaluate antibacterial and antiviral activity of silver nanoparticles using marine Actinomycete, Nocardiopsis alba, isolated from mangrove soil. Formation, size, and shapes of silver nanoparticles (AgNPs) were characterized by UV-visible spectroscopy, X-Ray Diffraction (XRD), FTIR and Transmission electron microscope (TEM). From the UV-visible spectroscopy, the a...
HIGHLY SELECTIVE AND SENSITIVE DETERMINATION OF Cr6+ (nM) IN GELATIN CAPSULE USING AgF/Ag2WO4 NANOCOMPOSITE
The present work deals with a novel synthesis of AgF/Ag2WO4 nanocomposite by co-precipitation method. The morphology and size of the synthesized AgF/Ag2WO4 nanocomposite were confirmed by Ultraviolet-Visible (UV-Vis) spectroscopy, Fourier Transform-Infrared (FT-IR) spectroscopy, Transition Electron Microscopy (TEM) and X-Ray Diffraction (XRD) analyses. The performance of the nanocomposite was succ...
The extensive study on O - methylated flavonoids reveals that substitution with methyl group enhances the radical scavenging behavior in certain compounds. Due to potential applications of C-glycosides in metabolic engineering, methylation in these flavonoids needs to be analyzed in both theoretical and experimental levels for their radical scavenging behavior. In this work naturally occurring C- ...
Background: Biofilm is a layer like aggregates of bacterial cells which are formed on biotic and abiotic surfaces. Pseudomonas aeruginosa plays an essential role in the aggregation of bacteria on biofilm formation. Quorum sensing and extracellular polysaccharide play a vital role in the biofilm formation in P. aeruginosa. The present study was aimed to investigate the anti-biofilm effect of lyophi...
IMPACT OF PROBIOTICS LACTOBACILLUS RHAMNOSUS AND LACTOBACILLUS CASEI ON LIPOGLYCEMIC AND ANTIOXIDATIVE STATUS OF DIABETIC RATS
Probiotics are live microorganisms, which when administered in adequate amounts confer a health benefit. There are very limited studies on antidiabetic effect of lactic acid bacteria despite their potentiality in reducing the risk of diabetes onset. The present study explored the effect of administering live culture of L. rhamnosus [MTCC No 8712] and L. casei [MTCC No 1408] in STZ induced diab...
A STUDY OF POSSIBLE PROTECTION BY NEFIRACETAM ON ESLICARBAZEPINE INDUCED MEMORY IMPAIRMENT IN TEMPORAL LOBE EPILEPSY
Memory impairment (MI) is commonly seen in epilepsy and is at times aggravated by antiepileptic therapy. Recent studies reported that co-administration of nootropic agent with an antiepileptic drug (AED) might decrease the MI. This study was designed to evaluate MI activity of Eslicarbazepine (ESL) in temporal lobe epilepsy (TLE) and to assess the protective effect of Nefiracetam (NEF) which is a ...
An unusual type of the long-lasting pyelonephritis demonstrating a long-lasting granulomatous disease resulting in a non-functional kidney in the patient is generally linked with xanthogranulomatous pyelonephritis. The name itself suggests this involves a granulomatous progression that is chronic, due to a chronic or sub-acute infection in the patient inciting a chronic but incomplete immune react...
The aim of the present study was to investigate antioxidant activity, total polyphenols and total flavonoids contents of extracts from two Moroccan Teucrium species (Teucrium polium and Teucrium aurum). The Antioxidant activity was evaluated in-vitro by three assays namely, free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and t...
The aim of this article was to develop pidotimod dispersible tablet and optimize the ingredients for the tablets. The effect of ingredients (diluents, disintegrants and lubricants) on the characteristics of the tablets was evaluated. The pidotimod dispersible tablets were prepared by wet granulation. The effect of diluents on the tablets was investigated by Carr’s index, dissolution, hardness, f...