DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC METHOD FOR QUANTITATIVE DETERMINATION OF RELATED SUBSTANCES PRESENT IN ELETRIPTAN HYDROBROMIDE DRUG SUBSTANCE
An efficient and sensitive RP-HPLC method was developed and validated for the estimation of related substances in Eletriptan hydrobromide drug substance which were identified and characterized by LCMS, FTIR, 1HNMR, 13CNMR techniques. The method was carried out on a Purosphere STAR RP-8e column at temperature 20°C using a phosphate buffer at pH 4.0 and solvent mixture consists of acetonitrile, wat...
APPLICATION AND COST-EFFECTIVENESS OF LAMP (LOOP-MEDIATED ISOTHERMAL AMPLIFICATION) TECHNOLOGY FOR AUTHENTICATION OF MEDICINAL PLANTS PODOPHYLLUM HEXANDRUM ROYLE
We have developed a novel LAMP-based molecular marker for easy and fast identification of Podophyllum hexandrum Royle (Indian May apple). It is an important medicinal plant valued all over the world. It have both anti-cancer (pro-oxidant ability) and radioprotective (antioxidant ability) effects respectively. The LAMP-based molecular was constructed based on genomic DNA of P. hexandrum that amplif...
Carbonic anhydrases (CAs, EC 18.104.22.168), are a superfamily of metalloenzymes in higher vertebrates, including humans. Sixteen distinct isoenzymes of CA are known to exist in mammals and most of these isoenzymes have been extensively investigated in terms of their biochemical properties, tissue distribution, and genetic control. There are cytosolic isozymes (CA I, CA II, CA III, CA VII and CA XIII), ...
A PHARMACOPHORE BASED DRUG DESIGN APPROACH TO OVERCOME IMATINIB RESISTANCE AND GET MORE POTENT BCR-ABL TYROSINE KINASE INHIBITOR
BCR-ABL Tyrosine Kinase inhibitor is an ideal pharmacological target for Chronic Myeloid Leukemia (CML). After the effective use of Imatinib as a therapeutic agent for Chronic Myeloid Leukemia, resistance has been observed in much patience with the treatment of Imatinib. The main objective of this study is to develop some new novel BCR-ABL Tyrosine Kinase inhibitor for the treatment of Chronic Mye...
A STUDY ON ATTITUDE AND SATISFACTION OF PATIENTS TOWARDS UNANI AND AYURVEDIC HEALTH CARE SERVICE WITHIN MEDICAL PLURALISM IN THE CONTEXT OF BANGLADESH
Unani and Ayurvedic heath care system is considerable areas of medical treatment in Bangladesh where patient can avail it from different Govt. or private hospital. This cross-sectional study was undertaken to find out the satisfaction of patients attending in this health care system from January to April 2014. A total of 240 respondents were interviewed with an interviewer administered semi-struct...
Peroxidase enzyme plays an important role in pharmaceutical, Industrial and various research laboratories. This enzyme can be purified by various different method. Our research trend was to purify the enzyme in a convenient and easy way. For this purpose a new affinity column was prepare by immobilizing PABA to N-HydroxySuccinamaideagarose gel. The presence of peroxidase was investigated on variou...
EVALUATION OF ANTIDIABETIC POTENTIAL OF METHANOLIC EXTRACT OF BENINCASA HISPIDA IN STREPTOZOTOCIN INDUCED DIABETIC RATS
The number of patients with Diabetes mellitus is increasing rapidly both in developed and developing countries around the world. The existing medications especially synthetic drugs often fail to bring back normal glycemic control without complications. Numerous herbal medicines are widely explored as alternative medicine in diabetes. The objective of this work was to evaluate one such herbal extra...
Kidney stones are a global affliction causing a great deal of morbidity and economic loss. The prevalence and control of nephrolithiasis is very important. Herbs and herbal drugs have created interest among the people by their clinically proven effects like immunomodulation, adaptogenic and antimutagenic. Also, the overuse of synthetic drugs, which results in higher incidence of adverse drug react...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF AMBROXOL HYDROCHLORIDE USING NATURAL POLYMER
Ambroxol hydrochloride is a potent mucolytic agent capable ofinducing bronchial secretions used in the treatment of respiratory disorders. The Sustained release matrix tablets containing 75 mg Ambroxol hydrochloride were developed using different drug: polymer ratios. Sustained release matrix tablets were prepared by wet granulation method. Granules wereprepared and evaluated for loose bulk densit...
Ensuring patient safety during and after clinical trials is the sole priority of the drug-development process. In both clinical trials and clinical practice, each patient must be treated according to his or her illness and needs. For this purpose, monitoring of patient safety at all levels of drug-development is given utmost importance. Such monitoring is a dynamic process having motive of protect...