Antimicrobial activity of 11 ethnomedicinal plant extracts was evaluated against five bacterial strains (Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Proteus vulgaris) and one fungal strain (Candida albicans). Plants were collected from different regions of Kashmir Valley and the ethnomedicinal data were gathered from traditional healers and elders of the stu...
Background: Actinodaphne hookeri Meissn. (Family Lauraceae), known as Pisa, is a moderate evergreen tree, found commonly in Chattisgarh, Western Ghats, Maharashtra, Karnataka, Orissa, Sikkim and North-Eastern parts of India. The leaves have been traditionally used in the treatment of diabetes and urinary disorders. The leaves were also known to possess potent antioxidant activity. Objective: Aim o...
Pharmaceutical industry and quality control laboratories needs of robust methods for analysis of drugs used in the treatment of life-threatening diseases such as hepatitis C. Using HPLC technique, a rapid, selective, precise and accurate method was developed and validated for the estimation of % drug release of Sofosbuvir in a pharmaceutical formulation. Stability indicating HPLC method was develo...
THE EFFECT OF SUBCHRONIC ADMINISTRATION OF ROSELLA (HIBISCUS SABDARIFFA L.) EXTRACT ON LEVELS OF UREUM, CREATININE, AND RENAL HISTOPATHOLOGY
Rosella (Hibiscus sabdariffa L.) calyx traditionally used to treat various diseases. There is limited evidence based could be found including the efficacy and safety. The present study was aimed to investigate the effects of subchronic administration of Rosella calyx extract on the renal function of female Sprague Dawley (SD) rats. The rosella calyx was extracted by 70% ethanol and evaporated with...
Sericin is a globular protein obtained from degumming of silk cocoon in the silk reeling process. The sericin film was synthesized for the application of antibacterial wound dressing, but it has a low physical property, hence the synthetic polymer was used in the synthesis of highly stable biocompatible film. The PVA based sericin film was prepared by solvent casting method by the addition of synt...
The current study involves evaluation of antioxidant potential of selected nutraceuticals like barley grass juice (Hordeum vulgare L.), ethanolic extracts of cashew apple (Anacardium occidentale L.) and sea lettuce (Ulva reticulata F.) in in-vitro experimental model using goat liver slices at different concentrations (100, 200, 400, 800 and 1600 mg/kg, p.o). The oxidative stress was induced using ...
EFFICACY AND COMPLICATIONS OF PROLONG LINEZOLID THERAPY IN METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) INFECTED SUBCUTANEOUS ABSCESS MODEL IN WISTAR RAT
Linezolid has a better choice for the eradication of both community and hospital acquired methicillin-resistant Staphylococcus aureus (MRSA) infections, but its use is limited because of its complications. The study elucidated the efficacy and complications of prolonged therapy of linezolid in MRSA infected rats. The rats were rendered neutropenic by an intraperitoneal injection of cyclophosphamid...
PREVALENCE OF MEASLES VIRUS INFECTION AMONG VACCINATED AND NON-VACCINATED CHILDREN IN NORTHERN INDIA
Introduction: Measles virus (MeV) is still a common acute illness caused by viruses belonging to the family Paramyxoviridae and genus Morbillivirus. The objective of this study was to determine the prevalence of MeV in both vaccinated and unvaccinated children and consecutively, testing the efficacy of MeV vaccination among children in north India. Materials and Methods: A total of 323 blood sampl...
ACTIVITY OF ETHYL ACETATE FRACTIONS OF TONGKAT ALI ROOTS (EURYCOMA LONGIFOLIA, JACK) ON BLOOD GLUCOSE LEVELS IN STREPTOZOTOCIN INDUCED DIABETIC RATS
This study is to evaluate two ethyl acetate fractions of “Tongkat Ali Roots” (TAR) namely fractions-1 and fraction-2 (F-1; F-2) on blood glucose levels in streptozotocin (STZ) induced diabetic rats. Each fraction used sixty rats which grouped into six groups (n=10). Group 1 is normal rats which received aqua dest; group 2 is diabetic rats which received STZ 60 mg/kg b.w., group 3 is diabetic r...
ANTIMALARIAL ACTIVITY AND TOXICITY EVALUATION OF THE ALKALOID-RICH FRACTION OF MOMORDICA CHARANTIA FRUITS
Introduction: We investigated to an in-vitro and in-vivo evaluation of antimalarial and toxicity of the alkaloid-rich fraction of Momordica charantia fruits. Materials and Methods: In-vitro and in-vivo antimalarial activity tests of Plasmodium falciparum strain 3D7 culture were performed on Plasmodium berghei-infected mice using suppressive and prophylactic methods, and evaluation of fraction toxi...