IMPROVEMENT IN PAIN RELIEF USING A DMSO BASED DICLOFENAC IN COMPARISON TO CONVENTIONAL DICLOFENAC GELS IN OSTEOARTHRITIS –A RANDOMIZED CONTROLLED TRIAL
Background: Topical NSAIDs are the first line choice of drug for management Osteoarthritis elderly patients, which produce less systemic exposure compared with oral NSAIDs. Now a day’s several topical formulations are available. This study provides a comparison between two various topical diclofenac formulations. Methods: 12 weeks, randomized controlled trial to evaluate dimethyl sulfoxide (DMSO...
EVALUATION OF THE HEPATOPROTECTIVE EFFECT OF UVARIA AFZELII AGAINST PARACETAMOL INDUCED LIVER TOXICITY IN WISTAR RATS.
Uvaria afzelii (UV) Sc Elliot (Annonaceae) locally is used in the treatment of kidney disorders, digestive problems, liver disorders, diabetes as well as gonorrhea. This study aims to investigate the possible hepatoprotective activities of the crude aqueous root extract of Uvaria afzelii against Paracetamol-induced hepatotoxicity with Silymarin being used as a reference standard. Twenty five (25) ...
In this study, in-situ raft forming Levofloxacin Suspension formulation was developed. In-vitro conditions like temperature, pH, and RPM simulating the in-vivo conditions like gastric pH, body temperature, and gastric motility respectively were identified as critical process parameters in system scale-up studies. Challenging and characterization were performed in-vitro. The working limits were ide...
The present study investigates neuroprotective effect of hydroxy citric acid (50%) on phenytoin induced cognitive impairment and oxidative stress in rats.Male Wistar rats were divided into 6 groups and each group received vehicle, phenytoin (25mg/kg, i.p) and hydroxy citric acid (400 and 800mg/kg, orally) for 14 days respectively. Memory and learning was evaluated by using the Rectangular maze, Mo...
Strychnos potatorum Linn. is a medium sized deciduous tree belonging to the family Loganiaceae. The collected seeds of Strychnos potatorum were dried and powdered. Methanolic extract of these seeds was prepared by cold maceration. The preliminary phytochemical screening of the crude extract revealed the presence of flavonoids and phenolic compounds. The crude extract was partitioned (gradient) wit...
IDENTIFICATION AND QUANTIFICATION OF OLEANOLIC ACID FROM CYCLEA PELTATA BY HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHY (HPTLC) METHOD
Objective: To identify and quantify oleanolic acid from the roots of cyclea peltata by HPTLC method. Methods: The Plant cyclea peltata is a perennial herb from Menispermacae family. The powdered roots of plant cyclea peltata were extracted with methanol. Methanolic extract prepared separated with n-butanol, chloroform, and ethyl acetate as total saponin, total alkaloid and phenolic compound fracti...
Objective: This study was an attempt to explore the latent of colon specificity approach utilizing pH-sensitive and time-dependent characteristics of polymers for defined colonic release of 5-Fluorouracil (5-FU). Method: The pellets were prepared by extrusion-spheronization method which is an industry-accepted method due to its ease of formulation. The prepared pellets were the matrix of 5-Fluorou...
The studies on the constituents of aerial parts of Stellaria media Linn. (Caryophyllaceae) have led to the isolation and characterization of three new compounds ─ (1), (2) and (3). Structure elucidation of the new compounds was carried out using 1H NMR, 13C NMR, Mass spectrometry together with other complementary techniques (UV and IR). The major findings of the study include: Compound 1 was sep...
SIMULTANEOUS ESTIMATION OF AMANTADINE HYDROCHLORIDE AND OSELTAMIVIR PHOSPHATE USING PRECOLUMN DERIVATIZATION TECHNIQUE
A simple, efficient HPLC method has been developed and validated for simultaneous determination of Amantadine hydrochloride and Oseltamivir phosphate using pre-column derivatization with phenyl isothiocyanate (PITC). The chromatography separation was achieved on Phenomenex C18 column of 250 × 4.6 mm 5 µm particle size, mobile phase used for chromatographic run consisted of acetonitrile and water...
ANTIMICROBIAL SCREENING AND ANTI-ULCEROGENIC EFFECTS OF LEPIDIUM SATIVUM EXTRACT ON H. PYLORI INDUCED GASTRIC ULCER IN A RAT MODEL
Purpose: Helicobacter pylori (H-pylori) infection has been commonly associated with gastric ulcers. Lepidium sativum (L. Sativum) is an herbaceous edible plant, botanically related to mustard and watercress with remarkable pharmacological features. In this study, we investigate the anti-microbial and anti-oxidant effect of L. sativum seed methanolic extract in-vitro and correlate this with the gas...