PROTECTIVE EFFECT OF BAUHINIA TOMENTOSA L. EXTRACT AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN WISTAR MALE ALBINO RATS
The aim of the present study was to explore the effect of aerial parts of Bauhinia tomentosa extract against gentamicin-induced nephrotoxicity. Thirty male Wistar albino rats were divided into five groups of six animals each. Animals served as Group I (normal control 5 ml/kg b.wt, p.o), Group II (toxic control), and Group III and IV (treatment groups 200 and 400 mg/kg b.wt, p.o) and Group V (stand...
The objective of the present investigation was to develop a sustained release (SR) tablets of Doxazosin Mesylate by wet granulation technique using a combination of synthetic polymers (Eudragit RS-100 and Eudragit RL-100). Different batches of Doxazosin Mesylate sustained release tablets were prepared by using microcrystalline cellulose as diluents by wet granulation technique. The compatibility o...
Doxofylline [7-(1,3-Dioxolan-2-ylmethyl) - 1,3-dimethyl purine-2,6-dione] is a Xanthine derivative drug used in the treatment of Asthma. The molecular formula is C11H14N4O4. Doxofylline is presently available in tablet form with high oral dosages of 400 mg, 800 mg and 1200 mg, Syrup with oral dosage of 100 mg/5mL and Suspension with oral dosage of 100 mg/5mL. It is also marketed as a combination d...
PARENTERAL ADMINISTERED SUSTAINED RELEASE PIPERINE MICROPARTICLES INTENDED FOR TREATMENT OF LIVER FIBROSIS
The objective of this work was to formulate and characterize microparticles containing piperine, and evaluate their activity against carbon tetrachloride (CCl4)-induced liver toxicity. Piperine microparticles were formulated by o/w emulsion solvent evaporation technique using poly-ε-caprolactone as a polymer. Four different microparticle formulations (PM1, PM2, PM3, and PM4) were prepared by vary...
Momordica cymbalaria (Hook, Fenzl) is a vine of Momordica genus found in the Indian states of Karnataka, Madhya Pradesh, Maharashtra, Andhra Pradesh and Tamil Nadu. The medicinal herb also been named Luffa tuberose (Roxb) or Momordica tuberose (Roxb). Momordica cymbalaria is commonly known as Karchikai (Kannada) or Athalakkai (Tamil) or Kasarakayee (Andhra Pradesh) and Kakrol (India). Momordica cy...
PHYTOCHEMICAL CHARACTERISATION AND PHARMACOLOGICAL EVALUATION OF METHANOLIC EXTRACT OF AVICENNIA ALBA
The history of herbal medicines is as old as civilization. For this purpose of ascertaining the phytochemical constituents, the present work was performed into the phytochemical investigation of the plant Avicenna alba. Separation and isolation of the constituents of interest, characterization of isolated compounds and investigation of the biosynthetic pathways of the particular pathway and quanti...
DOSE DEPENDENT ANTIDIABETIC ACTIVITY OF HYDRO-METHANOLIC EXTRACT (3:2) OF FLOWER OF M. BALBISIANA IN STREPTOZOTOCIN INDUCED DIABETIC MALE RAT
Background: Musa balbisiana Colla (Musaceae family) is used as folkloric medicine throughout India. Objective: To search out the potent dose of a hydro-methanolic extract of Musa balbisiana flower for antidiabetic and antioxidative activities in streptozotocin-induced diabetic rat. Material and Methods: The extract of the said plant part was administered orally at the dose of 5, 10 or 20 mg /100 g...
PAEDIATRICIANS COGNIZANCE ABOUT THE DELETERIOUS EFFECT OF ANTIBIOTICS AND DENTAL CARIES – A PRELIMINARY STUDY
Aim: To evaluate pediatricians’ cognizance about the use of antibiotics and dental caries. Materials and Method: 200 Pediatricians’ who were willing to participate were selected randomly from public and private medical hospitals in South India. A pretested questionnaire was distributed to the Paediatricians’ and was personally contacted to receive the responses within a week’s time. Descri...
BIOCHEMICAL STUDY OF AN ENDANGERED ETHNOMEDICINAL PLANT CURCULIGO ORCHIOIDES GAERTN. OCCURRING IN PURULIA DISTRICT OF WEST BENGAL, INDIA
Ethnic peoples from Purulia district of West Bengal in India use a lot of plants for their primary health care without studying phytochemical analysis and biological activities in detail. Main objectives of the present study are to evaluate the antibacterial and antioxidant activities of the whole plant extract of Curculigo orchioides using polar and nonpolar solvents. Total phenol content (TPC) w...
INVESTIGATION OF THE EFFECTS OF ETHANOL SEED EXTRACT OF GARCINIA KOLA ON HEMATOLOGICAL AND HEPATORENAL INDICES IN WISTAR ALBINO RATS
Garcinia kola is a known herbal plant which is widely consumed for many ethnomedicinal uses. This study was aimed at determining the effect of ethanol extract of G. kola seeds on levels of hematological as well as blood indices of liver (aspartate transaminase, alanine transaminase, alkaline phosphatase, total protein, and albumin) and kidney function (creatinine and urea). Extract (50, 100, 200 o...