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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 14 (2023) - Issue 7, July

Review Articles

 
Title
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1.

USEFUL MEDICINAL PLANTS HAVING ANTI-CANCEROUS AND ANTI-TUMOROUS MEDICINAL POTENTIAL OF WITHANIA SOMNIFERA (L.) DUNAL, ANDROGRAPHIS PANICULATA (BURM.F.) WALL AND GLYCYRRHIZA GLABRA (L.)

A study has reviewed three medicinal plants from India that have been traditionally used for treating and preventing diseases, including cancer. These plants, namely Withania somnifera (L.) Duna L, Andrographis paniculata (Burm.f.) Wall, and Glycyrrhiza glabra L., possess anti-cancer and anti-tumorous properties. They contain various bio-active constituents and secondary metabolites, such as Witha...

Pawan Kumar Sagar *, Asma Sattar Khan and Suryansh Kashyap

Drug Standardization Research Institute, CCRUM, Ministry of AYUSH), PCIM & H, Campus, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3221-30

3221-3230

857

606

2.

THE MYSTERY AND HISTORY OF ALZHEIMER’S DISEASE

Even though the malady of dementia has existed for thousands of years, the correlated neurodegenerative alterations taking place in certain regions of the human brain were detected in recent times. Today, we are aware that dementia is a primary manifestation of Alzheimer’s disease (AD). In 1907, Alöis Alzheimer described the symptoms of a 51-year-old woman, Auguste Deter, who was under his obse...

Milind Parle * Pinki Balhara and Sushila Kaura

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3231-37

3231-3237

915

310

3.

CHEMICAL CONSTITUENTS OF ANDROGRAPHIS PANICULATA (BURM.F) NEES: A REVIEW

Andrographis paniculata Nees is a valuable medicinal herb of Acanthaceae family, is used for centuries to treat several diseases including viral hepatitis, cirrhosis, malaria and diabetes. This medicinal plant has hepato-protective, immunological, anti-bacterial, anti-inflammatory, anti-oxidant and antithrombotic qualities. It has many important bioactive compounds such as diterpenoids, flavonoids...

Anju Bhatnagar

Department of Chemistry, D. B. S. (PG) College, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3238-45

3238-3245

1222

467

4.

A REVIEW ON PULSATILE DRUG DELIVERY SYSTEMS

In present days, solid oral drug dosage forms are widely used and the largest part of the entire drug delivery system due to their more, easy preferable route of administration and improved patient convenience nature. Most of the oral drug delivery systems show a distinctive drug release pattern, and the drug concentration is maintained within the limit of the therapeutic range. With technological...

P. SS. Prasanna Kumar * and L. Srinivas

Department of Pharmaceutics, GITAM School of Pharmacy, GITAM Deemed to be University, Rushikonda, Vishakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3246-54

3246-3254

963

317

5.

ETHNOMEDICINAL AND PHARMACOLOGICAL IMPORTANCE OF BACOPA MONNIERI: A REVIEW

Despite the considerable advancement in medical sciences and allopathic medicines, the use of complementary and alternative medicines has dramatically increased worldwide. Bacopa monnieri is one of the most important and highly studied medicinal plants that is being used as an ayurvedic or ethnomedicine for thousands of years. It improves intelligence rejuvenation and treats mental illness, fever,...

S. Das * and J. C. Kalita

Animal Physiology and Biochemistry Laboratory, Department of Zoology, Gauhati University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3255-63

3255-3263

622

270

6.

ROLE OF NEUROPEPTIDES IN HUMAN BEHAVIOUR

Neuropeptides are chemical messengers that are comprised with small chain of amino acid. Neuropeptides are synthesized and released by neurons. Neuropeptides belongs to class of neurotransmitters. Human Behaviour is dependent on social interaction and it is simply modulated by a human’s internal state. In humans, we observe different social contexts that can alter anxiety levels and modulate soc...

Padmaja Kore *, Abhijit Deshmukh, Ganesh Pore, Surabhi Shinde, Prajakta Tambe and Pradnya Khelbude

Department of Pharmacology, Progressive Education Society’s Modern College of Pharmacy, Yamunanagar, Nigdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3264-71

3264-3271

309

153

7.

POTENTIAL BIOMARKERS OF RHEUMATOID ARTHRITIS AS A TOOL FOR RESEARCH AND DEVELOPMENT OF NEW DRUG MOLECULE: A REVIEW

Rheumatoid Arthritis (RA) is an autoimmune inflammatory illness characterized by persistent synovial inflammation. It’s the most common form of arthritis that causes inflammatory changes in the tissue of joints, destroys cartilage and bones, and affects the quality of life. This diverse disease has a wide range of disease progression and treatment responses. Because the precise origin of rheumat...

Abhijita Talukder, Purbajit Chetia *, Nayanika Neog, Priyakshi Chutia and Bhargab Jyoti Sahariah

NETES Institute of Pharmaceutical Science, Mirza, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3272-80

3272-3280

329

137

8.

A REVIEW OF THE RELATIONSHIP BETWEEN ANTIDEPRESSANTS AND SUICIDE RISK

There are a variety of causes of death, but one of the most common is a suicide, which has an annual global average rate of roughly 13 per 1000000 people. Men commit suicide at a higher rate than women. Suicide rates were reduced by prescribing higher doses of current antidepressants; however, multiple ecological, cohort, case-control, and controlled clinical trials in patients with acute affectiv...

Padmaja Kore *, Pradnya Khelbude, Surabhi Shinde, Abhijit Deshmukh, Prajakta Tambe and Ganesh Pore

Department of Pharmacology, Progressive Education Society’s Modern College of Pharmacy, Yamunanagar, Nigdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3281-87

3281-3287

332

144

9.

A REVIEW OF HERBAL PLANTS USED IN THE TREATMENT OF RHEUMATOID ARTHRITIS

An inflammatory disorder with an uncertain cause, rheumatoid arthritis (RA), is primarily distinguished by progressive cartilage loss resulting in persistent polyarthritis and joint deformity. Studies indicate that pannus development, which harms the cartilage and the bone, is caused by synoviocyte cellular growth, albeit the exact pathophysiology of the condition has not yet been determined. Rece...

Hira Das *, Debgopal Ganguly, Sayan Hazra, Soumyadip Roy, Subhadip Barui and Sumit Mitra

Seacom Skills University, Kendradangal, Birbhum, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3288-95

3288-3295

340

156

10.

CARBON DOTS – AN EMERGING NANOPARTICLE FOR NANOMEDICINE

Carbon dots are small nanoparticles having a size of less than 10nm. They have distinctive properties such as chemical stability, water solubility, fluorescence emission, easy synthesis, and low toxicity. Because of their special properties, they have been applied in various scientific disciplines. The fluorescence property of Carbon dots enables them for various biomedical applications such as bi...

Jeya Jeyamani *, Suguna Rajendran and Renuka Radhakrishnan

Department of Microbiology, V. V. Vanniaperumal College for Women, Virudhunagar, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3296-05

3296-3305

299

154

11.

ETHANOPHARMACOLOGY, PHYTOCHEMICALS AND THERAPEUTIC POTENTIAL OF AILANTHUS EXCELSA ROXB: AN OUTLOOK

The genus Ailanthus, which includes both evergreen and deciduous species, is native to both Asia and northern Australia. Traditional medicine relies heavily on this plant, and various components of the plant are utilized to treat a wide range of illnesses. Herbal and ayurvedic drugs have gained worldwide attention over the past decade for their potential health and financial benefits. There are no...

Ankur Agrawal * and Subodh Kumar Dubey

School of Pharmacy, ITM University Gwalior, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3306-13

3306-3313

281

133

12.

DRUG DISCOVERY AND DEVELOPMENT: A BASIC APPROACH TO IMPROVE THE SUCCESS OF DRUG DISCOVERY

Drug discovery is a process that aims at identifying a compound therapeutically useful in curing and treating disease. This process involves the identification of candidates, synthesis, characterization, validation, optimization, screening, and assays for therapeutic efficacy. Once a compound has shown its significance in these investigations, it will initiate the drug development process earlier ...

Tarang Varshney, Shaily Saini and Aafreen *

SRMS College of Engineering, Technology & Research Bareilly, Bareilly, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3314-26

3314-3326

402

185

13.

A REVIEW ON RECENT ADVANCES IN EMERGING NANOPARTICLE-BASED BUCCAL DELIVERY SYSTEMS FOR ANTI-RETROVIRAL DRUG DELIVERY

The development of mucoadhesive buccal formulations has recently gained a great deal of attention. Despite several proposed solutions, drug permeability and regulated drug release via this mode of delivery remain concerns for successful therapy. Clinical uses for recent advances in nanotechnology have been examined. In addition to ensuring effective distribution, the use of nanoparticles in dosage...

Nayan Ajankar *, Smita S. Pimple and P. D. Chaudhari

Department of Pharmaceutics, Modern College of Pharmacy, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3327-36

3327-3336

248

135

14.

EVALUATION OF SERUM VITAMIN D AND VARIOUS ORGANS FUNCTION TESTSIN DIFFERENT TRIMESTERS OF PREGNANCY: A SYSTEMATIC REVIEW

Background: Vitamin D is a lipid-soluble vitamin that plays an important role in maintaining calcium and phosphorus homeostasis and promoting bone metabolism. It sustains normal values of calcium and phosphorus in the systemic circulation. If the exogenous calcium sources are insufficient, vitamin D together with the parathyroid hormone (PTH) will direct part of the bone calcium. Circulating serum...

Satya Prakash *, Raj Kumar and Indra Prasad Adhikari

Department of Biochemistry, BRD Medical College, Gorakhpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3337-44

3337-3344

239

126

15.

DENDRIMERS IS A SMART NOVEL CARRIER IN DRUG DELIVERY: AN INSIGHT

Multifunctional, versatile materials with multiple dendrimer branches have myriad binding sites and are in high demand for their drug binding, loading potential, and coatings. Dendrimers are among the latest generations of nano-systems that are potential drug carriers. Dendrimer chemistry is one of modern chemistry's most captivating and fastest-growing areas. Dendrimer research has grown exponent...

Suman *, Saddam, Shashi Alok and Ram Narayan Prajapati

Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3345-59

3345-3359

265

132

16.

OPHTHALMIC DRUG DELIVERY SYSTEMS FOR CONJUNCTIVITIS

Ophthalmic drug delivery is greatly onerous for a better remedial response in any type of disease state for instance, conjunctivitis, more commonly published as pinkeye, is an inflammation of the conjunctiva, a clear membrane that envelopes the outmost lamina of the eye and the inside surface of the eyelids. Usually, conjunctivitis is of the following classes depending on their origins of contagio...

Saddam *, Upendra Kumar Sharma, Bhawana Sharma, Shashi Alok and Suman

Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3360-73

3360-3373

301

139

Research Articles

 
Title
Views
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17.

A COMPARATIVE EVALUATION OF BIOACTIVE PROPERTIES OF RAW, FERMENTED, AND GERMINATED DEOILED FLAXSEED FLOUR EXTRACTS BY DIFFERENT SOLVENTS

The importance of flaxseeds in the food sector has been highly appreciated due to the presence of phytochemicals and antioxidants. The aim of the present study was to focus on the effect of different solvents used for the extraction of bioactive phytochemicals from raw, fermented, and germinated deoiled flaxseed flours and also evaluated their antioxidant activities. The phenolic content and flavo...

S. Ghosal, S. Sengupta and J. Bhowal *

School of Community Science and Technology, Indian Institute of Engineering Science and Technology, Shibpur, Howrah, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3374-91

3374-3391

441

327

18.

ISOLATION AND CHARACTERIZATION OF HEAVY METAL-REDUCING MICROBES FROM TANNERY EFFLUENT AND ITS ACTIVITY ON IMMOBILIZED BEADS

Heavy metal pollutants in tannery effluent can be removed using the bioremediation technique. This study intends to extract bacteria that may reduce heavy metals and molecularly characterize them using 16S rRNA PCR in samples taken from tannery effluent. It also studies their cell-free immobilized enzymatic activity. Thirteen bacterial isolates were identified based on morphological, cultural, and...

J. Raveena Jayam and C. Sivaraj *

ARMATS Biotek Training and Research Institute, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3392-03

3392-3403

412

200

19.

SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING STUDIES AND ANTHELMINTIC AND ANTI-CANCER ACTIVITY OF PYRAZOLE CONTAIN NOVEL INDOLIN-2-ONE DERIVATIVES

Background: Imidazole-5-one scaffold has been predicted in the important synthetic drug analogs, which gave valuable information for treatment and high binding affinity to the multiple receptors helpful drug development. Objective: To synthesize and evaluate the anthelmintic, anticancer, and Insilco docking studies of pyrazole contain novel Indole derivatives (4a-4h). Methods: In the present work,...

Hemalatha Sattu *, Sayeda Hinanaaz and Oleti Navneetha

Department of Pharmaceutical Chemistry, S. N. Vanita Pharmacy Mahavidyalaya, Tarnaka, Secunderabad, Hyderabad, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3404-13

3404-3413

549

291

20.

PHARMACOGNOSTIC AND ANTIMICROBIAL EVALUATION OF HORDEUM VULGARE LEAVES

Hordeum vulgare (Barley) grass is the best functional food for providing nutrition and eliminating toxins from human cells; however, its functional ingredients have also played an important role in health benefits. Flavonoids, saponarin, lutonarin, K, Ca, Se, dietary fiber, polysaccharide, alkaloid, glycoside, tannin, metallothionein and polyphenols are all found in barley grass. Microscopical stu...

Kiran, Vandana Garg * and Saloni Kakkar

Department of Pharmaceutical Sciences M. D. University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3414-20

3414-3420

424

280

21.

THE ICH GUIDELINES IN PRACTICE: FORCED DEGRADATION STUDIES OF DORIPENEM BY AN LC-MS COMPATIBLE RP-HPLC METHOD

In this manuscript, a fast, stability-indicating RP-HPLC method with UV detection was developed and validated to quantify doripenem in the bulk drug and its injectable formulation. The analysis was performed using Phenomenex (250 x 4.6mm, 5µm) ODS column with a flow rate of 1 mL min–1 and a SPD 20 A UV detector to monitor the eluate at 316 nm. The mobile phase was acetonitrile and 10 mM ammoniu...

Ceema Mathew *, Shashikala Metri, Gorja Ashok and Devilal Jarpula

Gokaraju Rangaraju College of Pharmacy, Osmania University, Bachupally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3421-27

3421-3427

451

231

22.

A CROSS-SECTIONAL STUDY ON SELF-MEDICATION FOR COVID-19 AND ASSOCIATED FACTORS AMONG ADULTS IN A RESIDENTIAL COLONY OF EAST DELHI

A cross-sectional study was conducted among 140 study subjects in an urban residential area of East Delhi selected by simple random sampling method to assess the prevalence of self-medication for Covid-19 and associated socio-demographic and economic factors. Data were collected by interviewing the study subjects using a pre-tested semi-structured interview schedule. The Mean+SD age of the study s...

Anjali Mongjam, Prithpal Singh Matreja, Reeta Devi * and Mongjam Meghachandra Singh

School of Health Sciences, Indira Gandhi National Open University, Maidan Garhi, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3428-36

3428-3436

364

6711

23.

EFFECT OF SOLVENT SYSTEMS AND EXTRACTION TECHNIQUES ON TOTAL PHENOL, TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF A POTENTIAL MEDICINAL PLANT TINOSPORA SINENSIS (LOUR.) MERR.

Tinospora sinensis (Lour.) Merr. belongs to the family Menispermaceae is, an important medicinal plant. Ayurveda, an Indian medicinal system, strongly advocates use of T. sinensis as a rejuvenator and several other therapeutic activities. The study's objectives were to assess the effect of the extraction procedure and different solvent systems on antioxidant, total phenol content and total flavono...

T. Nasrin * and L. R. Saikia

Department of Life Sciences, Dibrugarh University, Dibrugarh, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3437-43

3437-3443

253

143

24.

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL TETRAZOLE ANALOGUES OF FLAVONES AS ANTIMICROBIAL AGENTS

A series of flavones derivatives 11(a-j) have been synthesized and evaluated for their in-vitro antibacterial and antifungal activities. The antibacterial screening data showed that compounds with 4-methoxyphenyl (11c), 4-fluorophenyl (11d), and 2, 5-fluorophenyl (11h) substituent’s on tetrazole ring, showed the maximum activity against the organisms used. The antifungal screening revealed that ...

Adki Nagaraj * and Gutha Nageswara Rao

Department of Chemistry, Telangana University, Dichpally, Nizamabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3444-51

3444-3451

249

136

25.

METHOD DEVELOPMENT, VALIDATION AND FORCED DEGRADATION STUDIES OF NEW RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF REMOGLIFLOZIN AND TENELIGLIPTIN IN PURE AND TABLET DOSAGE FORM

According to ICH guidelines, an easy, cost-effective, accurate, and precise RP-HPLC method for simultaneously determining Remogliflzin and Teneligliptin was developed and validated. The drug's quantity was determined using a photodiode array (PDA) detector. The column was run in isocratic mode with mobile phase acetonitrile and ammonium phosphate buffer at a 40:60 ratio. The flow rate was one mill...

J. David Blessing Rani * and C. Asha Deepti

Department of Pharmacy, GITAM School of Pharmacy, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3452-61

3452-3461

412

215

26.

A DOUBLE-BLINDED RANDOMIZED CONTROLLED STUDY IN PATIENTS UNDERGOING FOREARM AND HAND SURGERIES TO STUDY THE EFFECT OF LOW DOSE DEXAMETHASONE AS AN ADJUVANT TO ROPIVACAINE IN AXILLARY BRACHIAL PLEXUS BLOCK”

Introduction: Ultrasound-guided axillary brachial plexus block is commonly used for forearm and hand surgery. Perineural dexamethasone 8mg has proved to prolong the duration of analgesia, but studies with low doses of dexamethasone are scarce. Hence this study was designed to determine the duration of analgesia with 2 mg dexamethasone used perineurally with ropivacaine. Methods: Fifty-Eight patien...

Kiran Petkar, Jyoti Petkar *, Bharati Ganar and Sarika S. Naik

Department of Anaesthesiology, Sri Chamundeshwari Medical College and Hospital, Channapatna, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3462-69

3462-3469

254

126

27.

DISCRIMINATING DERIVATIVE SPECTROPHOTOMETRIC CONCURRENT QUANTIFICATION OF LORATADINE AND AMBROXOL IN TABLET DOSAGE FORM

Understanding the preponderance of respiratory conditions with the symptoms like sore throat and cough being even more common, owing to the coronavirus outbreak. The improved resolution method was developed to quantify drugs Loratidine and Ambroxol from the most effective dosage regimen to treat sore throat and cough. An accurate, precise method was developed for concurrently estimating drugs from...

Syed Sara Afreen, Panikumar Durga Anumolu *, Pulusu Veera Shakar, Jampana Rama Tulasi, Karuna Devi Barla and Vijaya Durga Dumpala

Gokaraju Rangaraju College of Pharmacy, Department of Pharmaceutical Analysis, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3470-74

3470-3474

235

178

28.

FORMULATION AND IN-VITRO EVALUATION OF ANTI-AGING FACE CREAM CONTAINING LACTIC ACID AND COCOA BUTTER

The main aim of the current research is to formulate and evaluate the anti-aging cream containing lactic acid and cocoa butter. Skin health and beauty is regarded as one of the most important variables influencing general "well-being" and "health" perception in humans because of that, various anti-aging techniques have been created in recent years. Uneven pigmentation, increased wrinkles, loss of ...

R. A. Deshpande * and M. T. Mohite

Department of Quality Assurance & Technique, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3475-81

3475-3481

295

145

29.

ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF RED OCHRE TRITURATED WITH PUNICA GRANATUM (DADIM BHAVIT GAIRIKVATI)

Antibiotic or antifungal drug resistance is a major challenge in this era. Because the discovery and development of new drugs takes a long time. So, ancient medicine formulations are being checked for antimicrobial properties. Red ochre triturated with Punica granatum (Dadim bhavit gairikvati) is herbo-mineral formulation prepared by red ochre (Gairika/Ferric Oxide fe2O3) triturated with Punica g...

Avinash Ashok Shete *, Jayashree Patil, Ashwin Ashok Shete and Arati Prabhakar Dubewar

Department of Streerogaevam Prasutitantra, Dr. D. Y. Patil College of Ayurveda and Research Centre, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3482-86

3482-3486

292

128

30.

FORMULATION AND EVALUATION OF DRY POWDER SUSPENSION USING HERBAL SEED EXTRACT

Introduction: Herbs, which have been used to cure numerous ailments since ancient times, are important in building the foundation of modern medications. They are relatively safe to use, easily available, and also affordable. The present study aimed to investigate dry powder suspension formulated with Linum usitatissimum seeds extract, Cucurbita pepo seeds extract, Sesamum indicum seeds extract and...

Pratiksha G. Patil * and Varsha M. Jadhav

Department of Quality Assurance, Bharati Vidyapeeth’s College of Pharmacy, Sector 8, C.B.D. Belapur, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3487-91

3487-3491

527

172

31.

FORMULATION AND EVALUATION OF NUTRACEUTICAL DRY POWDER SUSPENSION USING MORINGA OLEIFERA LEAVES AND CELASTRUS PANICULATUS SEEDS EXTRACTS

Herbs, which have been used to cure numerous ailments since ancient times, play an important role in building the foundation of modern medications. The present study aimed to investigate the antioxidant potential of nutraceutical dry powder suspension formulated with Moringa oleifera leaves and Celastrus paniculatus seeds extract against DPPH (2,2-diphenyl-1-picryl-hydrazine-hydrate). Plant extrac...

Sunayana R. Sable *, Varsha M. Jadhav and Vilasrao J. Kadam

Department of Quality Assurance Bharati Vidyapeeth’s College of Pharmacy, C. B. D. Belapur, Thane, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3492-97

3492-3497

275

161

32.

A STUDY OF IN-VITRO WOUND HEALING ACTIVITY IN THE METHANOL EXTRACT OF PROTOREASTER LINCKII

A wound is an injury of living tissue or a break in the epithelial integrity of the upper layer of skin. This may lead to disturbance of skin anatomical structure and functions. Nowadays, wound healing is a challenging clinical problem. So, effective wound management is required. Different in-vitro, in-vivo and ex-vivo models have been developed to evaluate wound healing activity. The present stud...

A. Maria Selva Francis * and Jemma Hermelin Jesy Diaz

Department of Zoology, St. Mary’s College, Thoothukudi, Manonmaniam Sundaranar University, Abhishekapatti, Tirunelveli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3498-01

3498-3501

260

131

33.

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET CONTAINING ACETAZOLAMIDE

This entire study is based on the drug delivery system of the pharmaceutical company to design the drugs. In order to identify the effectiveness of the drug, this study has tried to identify the bonds between peptides & proteins. In this context, this study has chosen the drug acetazolamide and based on the chemical properties, it has made a calibration curve of the drugs in water solution. In...

Durga Kishora

Sagar Institute of Pharmacy & Technology, Gandhi Nagar, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3502-06

3502-3506

267

155

34.

METHOD DEVELOPMENT AND METHOD VALIDATION FOR TRACE LEVEL QUANTIFICATION OF TWO POTENTIAL GENOTOXIC IMPURITIES IN BAZEDOXIFENE ACETATE DRUG SUBSTANCE BY USING LC-MS (SIR MODE) SELECTIVE ION RECORDING WITH SHORT RUNTIME ANALYSIS

Bazedoxifene acetate represents a promising new treatment for osteoporosis. LC-MS SIR (Selective ion recording) mode, the shortest runtime method, was developed and validated for the trace level quantification of two potential genotoxic impurities, i.e., Impurity-A (1 – Benzyloxy – 4 - nitrobenzene) and Impurity – B (4-benzyloxy-2-bromopropiophenone) in Bazedoxifene acetate drug substance. ...

Chandramohan Alluri, Kiran Kumar Naramsetti and G. Veera Raghava Sharma *

Department of Chemistry, Institute of Science, GITAM Deemed to be University, Rushikonda, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3507-15

3507-3515

275

138

35.

FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF FAST-DISSOLVING SUBLINGUAL FILM CONTAINING CLOVE OIL

Clove oil is an essential oil made from the plant, Szygium aromaticum. It is commonly used to help ease digestive issues, relieve pain, and support respiratory conditions. This work aims to determine at what temperature sublingual films are formed most effectively during process. The given temperature batches were manufactured at 75 °C, 80 °C, 85 °C, 90 °C. The sublingual films were prepared b...

Meera Reddy Mayreddy, Srinija Gumudevelli, Radhakrishna Vankayala, Phanindra Vankayala and Sridhar Gumudevelli *

Formulation R & D, Ascent Pharmaceuticals Inc., New York, USA.

DOI: 10.13040/IJPSR.0975-8232.14(7).3516-21

3516-3521

302

141

36.

ASSESSMENT OF SELF-MEDICATION PRACTICES AMONG THE HEALTH CARE WORKERS IN THE CONTEXT OF COVID-19 PANDEMIC IN A TERTIARY CARE TEACHING HOSPITAL IN NORTH INDIA

Objective: To assess self-medication practices among healthcare workers in the context of the Covid-19 pandemic in a tertiary care teaching hospital of north India. Background: Self-medication practice is a common phenomenon worldwide but has been reported to be very common in developing countries like India. Self-medication practices have gained more significance with the emergence of the Covid-1...

Rohini Gupta * and Vishal R. Tandon

Department of Pharmacology & Therapeutics, Government Medical College, Jammu, Jammu and Kashmir, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3522-26

3522-3526

261

136

37.

ISOLATION, SCREENING AND IDENTIFICATION OF UREASE-PRODUCING BACTERIAL STRAIN BACILLUS SPECIES FROM MARINE SEDIMENTS

Marine microorganisms are a valuable source of novel enzymes with ideal characteristics because of the halophilic nature of marine bacteria. The present study aims to isolate, screen, and identify the marine bacterial strains from marine sediment samples that produce an enzyme urease with clinical and industrial applications. Marine sediment samples were collected and cultured on zobell marine aga...

V. Priyasenan * and K. S. Athira

Department of Biotechnology, SAS SNDP Yogam College, Konni, Pathanamthitta, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3527-32

3527-3532

296

142

38.

PHYTOPHARMACOGNOSTICAL STUDY OF AERIAL PARTS OF HOUTTUYNIA CORDATA THUNB.

Natural products are becoming increasingly important as alternative medicines and a source of pharmacotherapeutics either directly or as raw materials from which more or less complex chemical structures proven biological activity are isolated. Houttuynia cordata Thunb. is one of the important drugs, which is traditionally used as anti-inflammatory, diuretic, anti-pyretic and detoxicant. In Indo-ch...

Archana Modi * and Mamata Shah

Department of Pharmacognosy, Sardar Patel College of Pharmacy, Vidhyanagar-vadtal Road, Bakrol, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3533-38

3533-3538

253

128

39.

HPLC FINGERPRINTING OF ETHNOMEDICINAL ANTITUBERCULOSIS PLANTS

Modern phytochemical analysis in terms of fingerprinting of different bioactive phytoconstituents in the roots of Leptadenia reticulata and whole herb of Cocculus hirsutu belonging to the family Ascelpidiaceae and Menispermaceae respectively. High-performance liquid chromatography (HPLC) analysis of roots of Leptadenia reticulata and whole herb of Cocculus hirsutus were carried out to develop the ...

Khushboo Vaghela *, Dhara Bhatt, Bhavita Dhru and Maitreyi Zaveri

K. B. Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3539-43

3539-3543

246

149

40.

NOVEL RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF RESERPINE AND PIPERINE IN POLYHERBAL FORMULATION

A novel, simple, accurate, precise, robust High-Performance Liquid Chromatography method was developed to simultaneously estimate reserpine and piperine. This method was applied to standardize polyherbal formulation containing these markers as one of its ingredients. The markers were resolved using Prontosil C-18 column, with mobile phase acetonitrile and water containing 0.05% ortho-phosphoric ac...

U. D. Jaiswar, R. M. Patil and V. N. Jain *

Department of Quality Assurance, Oriental College of Pharmacy, Sector 2, Sanpada, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3544-49

3544-3549

280

136

41.

AN UPDATED RISK ASSESSMENT AS PART OF THE QBD-BASED ORALLY DISINTEGRATING TABLET DESIGN AND DEVELOPMENT

In this paper, a Quality by Design-guided and Risk Assessment (RA)-based study was performed to determine the Critical Material Attributes and the Critical Process Parameters. Direct compression method was applied for the preparation of ODT containing Brivaracetam using 22 factorial designs with the quantity of drug, pharmabust 500 and crosspovidone as independent variables. Pharmabust 500 and cro...

Kinjal Solanki *, Archana Pillai, Ajaysinh Parmar and Sandip Dholakia

Department of Pharmaceutics, Shankersinh Vaghela Bapu Institute of Pharmacy, Vasan, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3550-58

3550-3558

269

163

42.

HPTLC METHOD DEVELOPMENT AND VALIDATION FOR QUANTITATIVE ESTIMATION OF ELLAGIC ACID, GLYCYRRHIZIC ACID AND HESPERIDIN FROM PUNICA GRANATUM PEEL, GLYCYRRHIZA GLABRA ROOT AND CITRUS SINENSIS PEEL EXTRACT

The present study focuses on developing and validating a high-performance thin-layer chromatography (HPTLC) densitometry method for identifying and quantifying ellagic acid, glycyrrhizic acid and hesperidin in the ethanolic extract of Punica granatum, Glycyrrhizic glabra and Citrus sinensis. The separation was achieved by mobile phase for ellagic acid was Methanol: Water: Formic acid (3.8:4.7:0.8)...

Samruddhi R. Nale *, Varsha M. Jadhav and Vilasrao Kadam

Department of Quality Assurance, Bharati Vidyapeeth College of Pharmacy, C.B.D. Belapur, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3559-65

3559-3565

307

164

43.

ETHNOMEDICINAL PLANT DIVERSITY AND THEIR USAGE AMONG RURAL COMMUNITIES INNANTA FOREST REGION, KOTA DISTRICT, RAJASTHAN

Kota district is situated in the south-eastern region of Rajasthan and is well known for its floral biodiversity. The present study has been done in the Nanta forest area located in the Sakatpura forest range in forest division Kota. This area is still unexplored in terms of ethnomedicinal plant diversity, which provides a new area for research in human wellbeing and biodiversity conservation. The...

Anita Malav, Pragya Dadhich and Poonam Jaiswal *

Department of Botany, Janki Devi Bajaj Government Girls College, University of Kota, Kota, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3566-74

3566-3574

282

152

44.

RELATIONSHIP BETWEEN SOCIAL SKILLS AND PROBLEM BEHAVIOUR ON ACADEMIC PERFORMANCE OF THE CHILDREN WITH MILD INTELLECTUAL DISABILITY IN INCLUSIVE EDUCATION IN TRICHY DISTRICT

Background: Children with mild intellectual disabilities demonstrate wide diversity in academic and behavioural performance. They develop adequate social, personal, and communication skills. As adults, they function in a variety of contexts. Persons with moderate intellectual disabilities have limited intellectual abilities, have problems in abstracting and generalizing, and are not ready for muc...

G. Sasikala

P. G. & Research Department of Rehabilitation Science, Holy Cross College, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3575-84

3575-3584

337

144

45.

STUDY ON REMOVAL EFFICIENCY OF DIFFERENT MICROORGANISMS IN ANTIBIOTIC-PRODUCING PHARMACEUTICAL INDUSTRIES WASTEWATER

Antibiotic yield has been raised by numerous pharmaceutical firms in response to the rising population, the COVID-19 outbreak, and the introduction of several new diseases. Several heavy metals are used in the antibiotics' formulation. The release of antibiotics and heavy metal ions has wreaked havoc on the ecosystem. The issue with heavy metals is that the bulk of them last a long time in the env...

Sutripto Ghosh and Swati Chakraborty *

Department of Biotechnology, Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F, Nilgunj Rd, Sahid Colony, Panihati, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3585-95

3585-3595

241

140

46.

A COMMUNITY BASED STUDY TO EVALUATE THE EFFICACY OF CHATURJATADI SAMBHARAKA ON THE NUTRITIONAL STATUS OF CHILDREN WITH BALSHOSHA W.S.R. TO PROTEIN ENERGY MALNUTRITION

Introduction: The aim was this trial is to assess to evaluate the effect of “Chaturjatadi Sambharaka” in the management of malnutrition in Children. Material and methods: This research work was done in two phases. Phase one included demographic study and in phase two was clinical study. A Randomized open label-controlled trial was conducted on100 undernourished children of 1-10 years of age gr...

Vedprakash Meena * and Nisha Kumari Ojha

Department of Kaumarbhritya - Balroga, National Institute of Ayuveda, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.14(7).3596-10

3596-3610

249

130