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MEDICINAL SIGNIFICANCE OF NIGELLA SATIVA AND ITS SEEDS: RECENT UPDATES
N. sativa (black cumin seed) is popularly known for its medicinal significance such as Anticancer, Antioxidant, Anti-microbial, Anti-inflammatory, Anti-ulcer, Anti-parasitic, Anti-histamine, Analgesic, for skin rashes, hair treatment and also used as a flavoring agent. Recent reports reveal that the Nigella sativa seeds exhibit a potent effect on the Covid-19 virus. Further, N. sativa seed can be ...
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REVIEW OF GOUTY ARTHRITIS: A NEW PERCEPTION FOR THE TREATMENT OF OLD DISEASES
Gouty arthritis, an inflammatory joint disease, occurs due to the accumulation of Monosodium Urate (MSU) crystals in the joints, mainly at the metatarsophalangeal joints of the big toe. At present, the incidence and prevalence of gout are increasing globally. The various risk factors are responsible for the development of gouty arthritis, including nonmodifiable, modifiable, and genetic factors. U...
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FORMULATION AND EVALUATION OF BOSWELLIC LOADED TRASFEROSOMES HYDROGEL TO TREAT PSORIASIS
Transfersomes, which may penetrate mammalian skin, are notably ultra deformable (ultraflexible) lipid supramolecular aggregates. A type of formulation carrier system called a transfersome can transport medications with both low and high molecular weights transdermally. Transfersomes enter the underlying viable skin in an undamaged state through skin's stratum corneum pores that are smaller than it...
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GELATIN/PECTIN COMPOSITE FILM WITH CHARACTERIZATION AND APPLICATION
Due to its similarity to the cell membrane seen in living organisms, gelatin is a natural biopolymer commonly used in tissue engineering applications. However, the rheological properties of gelatin formulations preclude their use in extrusion-based bioprinting. Using pectin as a viscosities modifier and formaldehyde for gelatin as a gelatin-pectin crosslinking agent, we offer a technique in the cu...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL TETRAZOLE ANALOGUES OF FLAVONES AS ANTIMICROBIAL AGENTS
A series of flavones derivatives 11(a-j) have been synthesized and evaluated for their in-vitro antibacterial and antifungal activities. The antibacterial screening data showed that compounds with 4-methoxyphenyl (11c), 4-fluorophenyl (11d), and 2, 5-fluorophenyl (11h) substituent’s on tetrazole ring, showed the maximum activity against the organisms used. The antifungal screening revealed that ...
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THYROID DYSFUNCTION IN ACUTE CORONARY SYNDROME AND ITS PROGNOSTIC IMPLICATIONS
Background: Thyroid disorders impact the cardiovascular system through direct and indirect mechanisms and are associated with a significantly increased risk of vascular morbidity and mortality. We undertook this study to evaluate the prevalence of thyroid dysfunction in patients with acute coronary syndrome (ACS) and to study the impact of thyroid dysfunction on morbidity and mortality among those...
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EVALUATION OF ANTHELMINTIC ACTIVITY OF FICUS BENGHALENSIS BARK
The present study evaluated the Anthelmintic activity of Ficus benghalensis bark extract against Indian earthworm Pheretima posthuma and compared it with the standard drug Albendazole. The results showed that the extract exhibited significant Anthelmintic activity, as evidenced by the time of paralysis and time of death of worms. The extract also contained various phytochemical constituents, inclu...
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STUDY ON REMOVAL EFFICIENCY OF DIFFERENT MICROORGANISMS IN ANTIBIOTIC-PRODUCING PHARMACEUTICAL INDUSTRIES WASTEWATER
Antibiotic yield has been raised by numerous pharmaceutical firms in response to the rising population, the COVID-19 outbreak, and the introduction of several new diseases. Several heavy metals are used in the antibiotics' formulation. The release of antibiotics and heavy metal ions has wreaked havoc on the ecosystem. The issue with heavy metals is that the bulk of them last a long time in the env...
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IMPACT OF PHAGE THERAPY ON ANTIBIOTIC RESISTANCE: CLINICAL TRIALS BASED APPROACH
The advent of new diseases and the subsequent outbreak of the Covid-19 pandemic has resulted in a tremendous increase in both the production and consumption of antibiotics. While this has helped the economy expand, it has also led to the rise of a problem known as antibiotic resistance. Scientists and researchers worldwide are worried about the spread of antibiotic resistance among various bacteri...
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DESIGN AND DEVELOPMENT OF ORODISPERSIBLE FILM OF MIDODRINE HYDROCHLORIDE
This work aimed to develop and evaluate fast dissolving strip of Midodrine hydrochloride to overcome the conventional dosage form's limitations and enhance dissolution rate, fast onset of action and improved patient compliance. Various batches of the mouth-dissolving film were prepared by using various grades of hydroxypropyl methylcellulose (HPMC) polymer and plasticizers such as Polyethylene Gly...
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