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STUDY ON MOLECULAR DOCKING OF ‘NUCLEOCAPSID (N) PROTEIN OF SARS-COV-2’ AND ‘MCF-7’
The process of eliminating viral infection and massive control from spreading furthermore by any variants may lead to a pandemic in the near future. On the other aspect, the impact of eradicating by the initial stage to prevent, treat carcinoma to decline the affected and death rate to maximum amount by Molecular Docking. The quickest and easiest method to search out the potential drugs is by anal...
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DRUG UTILIZATION PATTERNS OF ANTI-DIABETIC AGENTSIN DIABETICS WITH CO-MORBIDITIES IN A TERTIARY CARE HOSPITAL: AN OBSERVATIONAL STUDY
Type 2 diabetes mellitus is a lifestyle disorder with a deficiency in insulin secretion or loss of insulin sensitivity in the body. As the prevalence is becoming more global, a focus was made on the innovation of analyzing the latest treatments. A prospective observational study on drug utilization patterns for diabetes was conducted on 119 diabetic patients admitted in a tertiary care hospital. A...
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GANODERMA LUCIDUM TOTAL TRITERPENES ALLEVIATE INFLAMMATION AND MODULATE ANTIOXIDANT STATUS IN FREUND’S COMPLETE ADJUVANT-INDUCED ARTHRITIC RATS
Ganoderma lucidum total triterpenes were evaluated for anti-inflammatory activity using carrageenan-induced acute and formalin-induced chronic paw oedema models in Swiss albino mice. The total triterpenes, at concentrations 10, 50, and 100 mg/kg b. wt. administered orally, showed 36.96%, 54.35%, 76.09% inhibition of acute and 41.86%, 62.79% and 79.07% inhibition of chronic inflammation. Total trit...
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FORMULATION AND DEVELOPMENT OF SOLID SELF-EMULSIFYING DRUG DELIVERY SYSTEM FOR CIPROFLOXACIN
The purpose is to formulate the solid self emulsifying drug delivery system (S-SEDDS) to improve poor aqueous solubility and dissolution of ciprofloxacin. A solubility study was carried out, and then Soyabean oil (as oil phase), Tween 20 (as surfactant), and Span 80 (as co-surfactant) were selected for preparation of emulsion by titration method. Adsorption to solid carrier technique was used for ...
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A SINGLE-CENTRIC, SINGLE-ARM PILOT STUDY TO EVALUATE THE SAFETY AND EFFECTIVENESS OF SWASA KUDORI CHOORANAM (SKC) IN THE MANAGEMENT OF SWASA KAASAM (BRONCHIAL ASTHMA) – A STUDY PROTOCOL
Background: Cuvācakācam (SwasaKaasam) is one of the twelve types of Kācam in Siddha System of Medicine and is clinically correlated with Bronchial Asthma. Asthma is a Non-Communicable Disease that affects global health invariably by affecting all age groups with 5th global rank in terms of Daly’s. According to GBD, 13.09% of the population in India suffered from asthma and the prevalence in P...
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FLAVONOIDS AS POTENTIAL DRUG AGAINST POST-COVID-19 MUCORMYCOSIS: AN IN-SILICO STUDY
Covid-19 associated mucormycosis rose sharply during India’s 2nd wave of coronavirus infections. The administration of immunosuppressive drugs led to increased susceptibility of patients to oppurtunistic diseases like mucormycosis. One of the causative species of mucormycosis is Rhizopus microsporus. For this study, we choose two chalcones and examined their ability to act as potential anti-muco...
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PHARMACEUTICAL POTENTIAL OF A RESOURCEFUL NITROGEN-CONTAINING HETEROCYCLE: PYRAZOLINE-A REVIEW
Heterocyclic chemistry has grown very rapidly, particularly in evaluating synthetic methods and investigating synthesized materials' bioactive properties. Heterocycle compounds are important in many facets of life's pharmacological activities. In their structure, many biologically active compounds such as amino acids, vitamins, hormones, nucleic acids, alkaloids, dyes, and drugs (natural and synth...
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STATISTICAL OPTIMIZATION OF TOPICAL CREAM CONTAINING VITAMIN D3 NANOPARTICLES FOR ANTI-AGING EFFECT: BOX-BEHNKEN DESIGN
Aging is defined as decreased maximal function and reserve capacity in all body, organs, resulting in an increased likelihood of disease and death. One of the reasons for Premature Aging is deficiency of Vitamin D3. The main aim of the research work is to develop and evaluate the Nanoparticle based Anti-aging cream of Vitamin D3 for Premature aging. Six formulations were prepared by Nano precipita...
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ESTIMATION OF SECONDARY METABOLITES AND TOXICITY TO ARTEMIA SALINA L. OF SELECTED PLANTS OF FAMILY COMBRETACEAE: AN APPROACH FOR SCREENING OF HERBAL PREVENTIVE AGENTS
Objective: Combretaceae, a large family, includes more valuable species that are used against many diseases and disorders along with cancer therapy. Cancer is a very common lethal disease throughout the world. Keeping this in view, two species are Combretum roxburghii Spreng and Terminalia catappa L. selected for present studies to provide baseline data for future formulation. Methods: Phytochemic...
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DESIGN OF A NOVEL PHOTOBIOREACTOR FOR THE OPTIMIZATION OF GROWTH PARAMETERS OF SCENEDESMUS DIMORPHUS AND UTILIZATION OF DAIRY WASTE FOR BIOENERGY CONVERSION
Scenedesmus dimorphus isone of the widely exploited microalgae in several arenas of science, such as in food, nutraceuticals, agriculture, and pharmaceutical industries due to its high nutritional content and bioactivities. The present study designed a novel, cost-effective, eco-friendly, easy-to-operate and rectangular photobioreactor using glass material. Photobioreactor was provided with monoch...
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