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DRUG UTILIZATION PATTERNS OF ANTI-DIABETIC AGENTSIN DIABETICS WITH CO-MORBIDITIES IN A TERTIARY CARE HOSPITAL: AN OBSERVATIONAL STUDY
Type 2 diabetes mellitus is a lifestyle disorder with a deficiency in insulin secretion or loss of insulin sensitivity in the body. As the prevalence is becoming more global, a focus was made on the innovation of analyzing the latest treatments. A prospective observational study on drug utilization patterns for diabetes was conducted on 119 diabetic patients admitted in a tertiary care hospital. A...
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GANODERMA LUCIDUM TOTAL TRITERPENES ALLEVIATE INFLAMMATION AND MODULATE ANTIOXIDANT STATUS IN FREUND’S COMPLETE ADJUVANT-INDUCED ARTHRITIC RATS
Ganoderma lucidum total triterpenes were evaluated for anti-inflammatory activity using carrageenan-induced acute and formalin-induced chronic paw oedema models in Swiss albino mice. The total triterpenes, at concentrations 10, 50, and 100 mg/kg b. wt. administered orally, showed 36.96%, 54.35%, 76.09% inhibition of acute and 41.86%, 62.79% and 79.07% inhibition of chronic inflammation. Total trit...
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SYNTHESIS, SPECTROSCOPIC INVESTIGATION AND BIOEFFICACY OF SOME NOVEL SCHIFF BASE METAL (II) COMPLEXES
Two monobasic bidentate ligands L1H [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazine-carboxamide] and L2H [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene)hydrazinecarbothioamide] were synthesized by the condensation of [2-(5-Bromo-2-dihydro-2-oxo-1H-indol-3-ylidene) with semicarbazide and thiosemcarbazide, which formed a series of complexes with cobalt(II) and nickel(II). The ligands ...
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FORMULATION AND DEVELOPMENT OF SOLID SELF-EMULSIFYING DRUG DELIVERY SYSTEM FOR CIPROFLOXACIN
The purpose is to formulate the solid self emulsifying drug delivery system (S-SEDDS) to improve poor aqueous solubility and dissolution of ciprofloxacin. A solubility study was carried out, and then Soyabean oil (as oil phase), Tween 20 (as surfactant), and Span 80 (as co-surfactant) were selected for preparation of emulsion by titration method. Adsorption to solid carrier technique was used for ...
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PREVALENCE AND PREDICTORS OF DRUG-RELATED PROBLEMS AMONG MEDICAL WARD PATIENTS IN A SECONDARY CARE REFERRAL HOSPITAL: A PROSPECTIVE HOSPITAL-BASED INTERVENTIONAL STUDY
Drug-Related Problem (DRP) affects the hospital stay, healthcare budget, quality of life, morbidity, and mortality. The study aims to assess the prevalence and predictors of DRPs in hospitalized patients and provide intervention. A prospective interventional study was conducted in the in-patient medical department of the NGO hospital. A total of 310 subjects were enrolled and screened for the pres...
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STATISTICAL OPTIMIZATION OF TOPICAL CREAM CONTAINING VITAMIN D3 NANOPARTICLES FOR ANTI-AGING EFFECT: BOX-BEHNKEN DESIGN
Aging is defined as decreased maximal function and reserve capacity in all body, organs, resulting in an increased likelihood of disease and death. One of the reasons for Premature Aging is deficiency of Vitamin D3. The main aim of the research work is to develop and evaluate the Nanoparticle based Anti-aging cream of Vitamin D3 for Premature aging. Six formulations were prepared by Nano precipita...
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A SINGLE-CENTRIC, SINGLE-ARM PILOT STUDY TO EVALUATE THE SAFETY AND EFFECTIVENESS OF SWASA KUDORI CHOORANAM (SKC) IN THE MANAGEMENT OF SWASA KAASAM (BRONCHIAL ASTHMA) – A STUDY PROTOCOL
Background: Cuvācakācam (SwasaKaasam) is one of the twelve types of Kācam in Siddha System of Medicine and is clinically correlated with Bronchial Asthma. Asthma is a Non-Communicable Disease that affects global health invariably by affecting all age groups with 5th global rank in terms of Daly’s. According to GBD, 13.09% of the population in India suffered from asthma and the prevalence in P...
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PHARMACEUTICAL POTENTIAL OF A RESOURCEFUL NITROGEN-CONTAINING HETEROCYCLE: PYRAZOLINE-A REVIEW
Heterocyclic chemistry has grown very rapidly, particularly in evaluating synthetic methods and investigating synthesized materials' bioactive properties. Heterocycle compounds are important in many facets of life's pharmacological activities. In their structure, many biologically active compounds such as amino acids, vitamins, hormones, nucleic acids, alkaloids, dyes, and drugs (natural and synth...
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IN-VITRO ANTHELMINTIC EVALUATION OF HIBISCUS ROSA-SINESIS (L) AND AZADIRACHTA INDICA (L) LEAVES AGAINST HELMINTH PARASITE OF THE GOAT: A COMPARATIVE STUDY
The comparative study designed to evaluate the anthelmintic potential of the methanolic extracts of Hibiscus rosa-sinesis (L) and Azadirachta indica (L) leaves against helminth: Haemonchus spp., an abomasal parasite For this study various concentrations (1, 2.5, 5.0, 10.0 mg/ml) of both the extracts were screened. 1 mg/ml concentration of Albendazole (ABZ) was used as a positive control (referen...
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ESTIMATION OF SECONDARY METABOLITES AND TOXICITY TO ARTEMIA SALINA L. OF SELECTED PLANTS OF FAMILY COMBRETACEAE: AN APPROACH FOR SCREENING OF HERBAL PREVENTIVE AGENTS
Objective: Combretaceae, a large family, includes more valuable species that are used against many diseases and disorders along with cancer therapy. Cancer is a very common lethal disease throughout the world. Keeping this in view, two species are Combretum roxburghii Spreng and Terminalia catappa L. selected for present studies to provide baseline data for future formulation. Methods: Phytochemic...
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