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BENEFITS OF BALANCE TRAINING TO MAINTAIN EQUILIBRIUM AMONG OLD AGE PEOPLE
Introduction: Balance is an integral component of daily (functional) activities. It is very sensitive, complex and multifactorial. It is the ability to maintain the projection of the body’s centre of mass within manageable limits of the base of support, as in the standing or sitting or in transit to a new base of support, as in walking pattern (1). In old age ability to maintain balance is low a...
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AMELIORATIVE POTENTIAL OF MORINGA OLEIFERA AQUEOUS LEAF EXTRACT ON PARACETAMOL-INDUCED TESTICULAR TOXICITY IN ADULT MALE SPRAGUE-DAWLEY RATS
Testicular toxicity has been associated with long-term paracetamol usage. Moringa oleifera is known to eliminate toxins from organs and restore functionality. This study seeks to ascertain the potency of moringa in ameliorating paracetamol-induced testicular toxicity. Forty nine (49) Sprague-Dawley rats were randomly assigned into seven (7) groups composed of 7 rats each treated for 5 weeks. One g...
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IN-VITRO SENSITIVITY OF SALMONELLA TYPHI ISOLATES FROM POULTRY FARMS TO SELECTED BRANDS OF CIPROFLOXACIN ON THE GHANAIAN MARKET
Poultry products are a major source of animal protein in Ghana. However, disease outbreaks have constantly threatened increased poultry production in some regions of the country. The most common source of human salmonellosis is food of poultry origin. The evolution of resistant strains of Salmonella in natural environments and animal houses presents a serious public health concern. Fluoroquinolone...
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PHARMACOGNOSTIC, PHYTOCHEMICAL AND PHYSICO-CHEMICAL EVALUATION OF LEAVES OF TRAGIA INVOLUCRATA LINN.,
Background: Tragia involucrata Linn., leaves are traditionally used for the treatment of liver disorders, eczema, viral infections, headache, respiratory infections, etc. There is lack of documentation of safety data and non-availability of quality control standards for the ayurvedic traditional medicines. Aim & Objective: The aim of the study was designed to determine the pharmacognostic, phy...
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FORMULATION AND IN-VITRO EVALUATION OF POLYETHYLENE GLYCOL BASED ORAL MUCOADHESIVE GELS OF TACROLIMUS MONOHYDRATE
Oral Lichen Planus (OLP) is a rare chronic autoimmune mucocutaneous inflammatory disease characterized by painful oral lessions. Immunosuppressive agent Tacrolimus monohydrate is one of the effective therapy options for OLP as it possesses benefits such as greater safety and efficacy at lower doses over currently employed topical corticosteroids. From amongst its topical dosage forms, mucoadhesive...
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GANODERMA LUCIDUM TOTAL TRITERPENES ALLEVIATE INFLAMMATION AND MODULATE ANTIOXIDANT STATUS IN FREUND’S COMPLETE ADJUVANT-INDUCED ARTHRITIC RATS
Ganoderma lucidum total triterpenes were evaluated for anti-inflammatory activity using carrageenan-induced acute and formalin-induced chronic paw oedema models in Swiss albino mice. The total triterpenes, at concentrations 10, 50, and 100 mg/kg b. wt. administered orally, showed 36.96%, 54.35%, 76.09% inhibition of acute and 41.86%, 62.79% and 79.07% inhibition of chronic inflammation. Total trit...
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VALIDATED UFLC-MS/MS METHOD FOR THE QUANTITATIVE ESTIMATION OF PALIPERIDONE IN RABBIT PLASMA; ADAPTABILITY TO IN-VIVO BIOAVAILABILITY STUDY
A simple gradient ultrafast liquid chromatography-tandem mass spectrometry method was developed and validated for the quantitative estimation of paliperidone in rabbit plasma matrix as per USFDA, and EMA guidelines using a stable isotope-labeled paliperidone-d4 was added as an internal standard. The separation was achieved on a Hypersil BDS C18 column (4.6 mm × 10 cm, 5 µm) with the mobile phase...
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A NEW RP-UPLC METHOD DEVELOPED FOR THE SIMULTANEOUS DETERMINATION OF TELMISARTAN AND AZELNIDIPINE IN DOSAGE FORMS
A new, precise, and sensitive ultra-performance liquid chromatography method for simultaneous estimating Telmisartan and Azelnidipine in bulk and tablet dosage form was developed and validated. The chromatographic separation was achieved by using the HSS C18 (100 x 2.1 mm, 1.8m) column. A mixture of buffer and ACN (70:30 v/v) was pumped through the column at a flow rate 0.3 mL/min. The temperature...
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CHEMICAL CHARACTERISATION, EVALUATION OF ANTIOXIDANT ACTIVITY AND ACUTE TOXICITY OF POLAR EXTRACTS OF TABERNAEMONTANA CRASSA BENTH (FAMILY APOCYNACEAE)
Tabernaemontana crassa Benth, synonym Tabernaemontana jollyana Pietre ex Stapf, is a Central African pharmacopoeia plant whose stem bark is widely used in traditional medicine. The aim of this study was to evaluate the acute toxicity of aqueous extracts of this species. Preliminary phytochemical tests carried out on the different crude extracts of T. crassa revealed the following chemical groups: ...
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PRECLINICAL ASSESMENT OF WOUND HEALING ACTIVITY OF SEED EXTRACT OF AZADIRACHTA INDICA
Medicinal plants are important for pharmacological research and drug development. Aim and Objective: The aim and objectives of present study was to evaluate the wound healing activity of seed oil of Azadirachta indica in Excision and Incision wound models in rats. Result Discussion: The study thus demonstrated the wound healing activity of Neem seed oil and found to be effective in the functio...
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