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NITISINONE IN HUMAN PLASMA: UPLC-MS/MS ASSAY VALIDATION AND STABILITY STUDIES
A simple, precise, and rapid ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS method for determination of nitisinone in 20 µl human plasma was developed and validated. Nitisinone 6C13 was used as an internal standard (IS). Chromatographic analysis was performed on an Atlantis dC18 column (2.1 x 100 mm, 3 µm) using a mobile phase consisting of methanol and...
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COMPARATIVE STUDY BETWEEN RESULTS OF RETROGRADE INTRAMEDULLARY NAILING (RN) VS LOCKED PLATING (LP) IN TREATMENT OF DISTAL FEMUR FRACTURES: A PROSPECTIVE ANALYSIS
Introduction: Distal femoral fractures are among challenging orthopaedic injury constituting 0.4% of all fractures. Despite recent evaluation in operating techniques and surgical implants, debate continues around the choice of implant for various type of distal femur fractures. Method and Material: In prospective randomized study from 2020 to 2022, analysis of 40 patients was done out of which 20 ...
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FORMULATION AND EVALUATION OF EFFERVESCENT FLOATING TABLETS OF TIZANIDINE HYDROCHLORIDE USING COMBINATION OF POLYMERS
The present study was carried out with an objective of formulation and evaluation of effervescent floating tablets of Tizanidine hydrochloride using combination of polymers. The floating tablets were prepared using HPMC and Tara gum as a combination of polymers. The tablet was prepared by direct compression method. The effect of polymer concentration was evaluated for gastroretention and sustained...
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A PROSPECTIVE COMPARATIVE STUDY OF LETROZOLE AND CLOMIPHENE CITRATE IN OVULATION INDUCTION IN WOMEN HAVING PCOS
Introduction: Clomiphene citrate (CC) is the primary drug of choice for ovulation induction in PCOS but resistance to ovarian stimulation is frequent observation with CC. Letrozole (Let), an Aromatase Inhibitor (AI) induces folliculogenesis by releasing hypothalamo-pituitary axis from tonic inhibitory effect of estrogen. Aim: To compare the rate of folliculogenesis, number of follicle count, ovula...
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