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QUALITY OF LIFE-RELATED TO WORK PRODUCTIVITY AND PHYSICAL FUNCTIONING IN MIGRAINE PATIENTS: A SYSTEMATIC REVIEW AND NETWORK-META ANALYSIS
Background: Migraine is one of the major causes of disability affecting the productivity, physical, psychological and social well-being of patients. To conduct a systematic review and network meta-analysis (NMA) of randomized trials investigating the effect of anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) on productivity and physical functioning of adults migraineurs....
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METABOLIC DEFECTS OF THYROID HORMONE IN THE EMBRYONIC STAGE AUGMENT THE RISK OF DEVELOPING GESTATIONAL DIABETES MELLITUS AND OTHER SUSCEPTIBLE FACTORS
The objective of the study is to elucidate the association between thyroid dysfunction and increased risk of developing gestational diabetes mellitus (GDM) and assess the other risk factors for developing GDM. Retrospective observational research was carried out on 204 patients. Of these, pregnant women greater than 18 years were considered and recruited based on inclusion and exclusion criteria. ...
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ALLOPOLYHERBAL GEL FORMULATION AGAINST MICROORGANISM: IN-VITRO STUDIES
The cases of skin infections are increasing daily, and the conventional treatment loses its strength in treating those skin infections because of resistance of the microorganisms against the medications, including antibacterial as well as antifungal with the topical and oral administration, or both. The advancement of the treatment of treating skin infections by the combination with the synthetic ...
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DESIGN, DEVELOPMENT AND CHARACTERIZATION OF SOLID DISPERSION OF QUERCITIN LOADED ORAL WAFERS
Quercetin (3, 3ʹ, 4ʹ, 5, 7-pentahydroxyl-flavone) is a flavonol, belonging to the class of plant secondary metabolites known as flavonoids. Quercetin and its derivatives have various beneficial effects against ailments like inflammation, oxidative stress, and cancer. The present research work aimed to prepare and characterize quercetin's solid dispersion (SD) to enhance solubility and thereby di...
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OVERVIEW OF SOLID LIPID NANOPARTICLES FOR IMPROVED ANTI-CANCER DRUG DELIVERY
Nanoparticles with lipids as a constituent are called "solid lipid nanoparticles" (SLNs). Based on the most recent trends, SLNS is a promising approach for overcoming multiple barriers in drug delivery. Through SLNs, maximized drug payload to the site of action for different pharmaceutical drugs can be achieved. They range in size from 10nm to 1000nm and possess a solid lipid core matrix that aid...
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AMLODIPINE-INDUCED GINGIVAL HYPERPLASIA IN CHRONIC PERIODONTITIS: A CLINICAL CASE REPORT WITH ONE YEAR FOLLOW-UP
Background: Drug-induced gingival overgrowth (DIGO) is a common side effect of certain medications used for non-dental purposes, notably anticonvulsants, calcium channel blockers (CCBs), and immunosuppressants. These drugs, despite differing pharmacologically, inhibit intracellular calcium ion influx, leading to a decrease in collagenolytic activity and an increase in fibroblasts and collagen synt...
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DEVELOPMENT OF VALIDATED HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF FERULIC ACID AND ELLAGIC ACID
A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and completely validated for the estimation of ellagic acid and ferulic acid in herbal formulation. Quantification was carried out with pre-coated silica gel aluminium plate G60F254 (10x10cm) as stationary phase, mobile phase consisting of Ethyl acetate: toluene: formic acid: methanol (3.5:...
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CORRELATION OF THE LEVELS OF HIGH SENSITIVITY C-REACTIVE PROTEIN (hs-CRP) IN PATIENTS DIAGNOSED WITH METABOLIC SYNDROME
Objectives: Metabolic syndrome (MetS) is a cluster of several metabolic disorders including hyperglycemia, reduced high density lipoprotein cholesterol (HDL-C), raised triglyceride level in serum, hypertension and abdominal obesity. The independent risk factors of high sensitivity C-reactive protein (hs-CRP) levels may have a significant impact on evaluating the prevalence of MetS components in ...
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ANTIDIABETIC POTENTIAL OF HYDROALCOHOLIC EXTRACT OF LEAVES OF NYCTANTHES ARBORTRISTIS IN ADRENALINE AND ALLOXAN-INDUCED DIABETIC RATS
Diabetes mellitus, a metabolic disorder, is a serious universal health problem. The incidence of the disease is increasing in the world in all ethnic groups. Various medicinal plants are conventionally used in the treatment or management of the disease. In this investigation, an attempt was taken to evaluate the antidiabetic property of hydroalcoholic extract of leaves of Nyctanthes arbortristis i...
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PATTERN, CAUSALITY ASSESSMENT AND SEVERITY OF SUSPECTED ADVERSE DRUG REACTIONS REPORTED AT TERTIARY CARE TEACHING HOSPITAL
Background: Present study was conducted to evaluate pattern, causal association and severity of suspected Adverse Drug Reactions (ADRs) at a tertiary care teaching hospital in western India. Materials & Method: Spontaneous collection of suspected ADRs was done over a period of one year. Demographic data, suspected drug group/s, causal association, severity & preventability scale from the r...
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