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ANTIDIABETIC POTENTIAL OF HYDROALCOHOLIC EXTRACT OF LEAVES OF NYCTANTHES ARBORTRISTIS IN ADRENALINE AND ALLOXAN-INDUCED DIABETIC RATS
Diabetes mellitus, a metabolic disorder, is a serious universal health problem. The incidence of the disease is increasing in the world in all ethnic groups. Various medicinal plants are conventionally used in the treatment or management of the disease. In this investigation, an attempt was taken to evaluate the antidiabetic property of hydroalcoholic extract of leaves of Nyctanthes arbortristis i...
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PATTERN, CAUSALITY ASSESSMENT AND SEVERITY OF SUSPECTED ADVERSE DRUG REACTIONS REPORTED AT TERTIARY CARE TEACHING HOSPITAL
Background: Present study was conducted to evaluate pattern, causal association and severity of suspected Adverse Drug Reactions (ADRs) at a tertiary care teaching hospital in western India. Materials & Method: Spontaneous collection of suspected ADRs was done over a period of one year. Demographic data, suspected drug group/s, causal association, severity & preventability scale from the r...
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EVALUATION OF ANTHELMINTIC ACTIVITY OF FICUS BENGHALENSIS BARK
The present study evaluated the Anthelmintic activity of Ficus benghalensis bark extract against Indian earthworm Pheretima posthuma and compared it with the standard drug Albendazole. The results showed that the extract exhibited significant Anthelmintic activity, as evidenced by the time of paralysis and time of death of worms. The extract also contained various phytochemical constituents, inclu...
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MACHINE LEARNING STRATEGIES FOR DRUG DISCOVERY AND DEVELOPMENT
This review paper provides a comprehensive overview of the role of machine learning (ML) in drug discovery and development within the pharmaceutical industry. It begins by outlining the foundational concepts of machine learning, highlighting its ability to enhance decision-making and improve accuracy through data analysis. The paper emphasizes the growing adoption of ML techniques across the pharm...
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PREDICTION OF POTENTIAL INHIBITORS SIMILAR TO REMDESIVIR (GS-5734) AGAINST 7BTF SARS COV 2 RNA DEPENDENT RNA POLYMERASE – AN IN-SILICO APPROACH
The novel Corona Virus Disease - 19 (COVID-19) is a Contagious disease spreading among Animals and Humans, a Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS CoV2). The First case was identified in Wuhan, China as the disease has unfolded worldwide to the continuing pandemic. It created more infected cases and deaths worldwide, creating an urge for newer drugs of manipulate the Ongoing Pandem...
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INVESTIGATION OF ANTI-SWARMING, ANTI-BIOFILM AND ANTI-QUORUM SENSING POTENTIAL OF SOME ORGANIC TEA OF DIFFERENT BRANDS FROM INDIA
The emergency to find a solution to multidrug resistance of bacteria due to the abuse of antibiotics leads to the search for new antibacterial pathways. Quorum sensing (QS), or bacterial cell to cell communication, is a cell-density-dependent bacterial response. It is mediated by hormone-like compounds called autoinducers (AIs). QS-dependent regulation of gene expression controls various phenotype...
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REMARKABLE ANTI-TRYPANOSOMA CRUZI ACTIVITY IN SELECTED SALVADORAN PLANT SPECIES
In Latin America, Chagas is one of the most prevalent diseases, and current chemotherapy with benznidazole and nifurtimox is ineffective in chronic phase. Therefore, the development of new drugs, especially for the chronic stage of the infection, is urgently needed. Performing an in-vitro anti-trypanosome assay, we analyzed 114 plant species from Salvadoran flora, resulting in 34 active plants aga...
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ROLE OF DIFFUSION-WEIGHTED IMAGING IN THE EVALUATION OF INTRACRANIAL LESIONS
This study investigates the diagnostic utility of Diffusion Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) values in evaluating intracranial lesions. A cross-sectional analysis of 44 patients was conducted, examining age and gender distribution, histopathological types, and grades of brain tumors. The highest proportion of individuals (22.7%) was within the 0-10 age range, with ma...
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EVALUATION OF ANTI-NOCICEPTIVE EFFECT OF ETHANOLIC EXTRACT OF VANILLA PLANIFOLIA SEEDS IN ANIMAL MODELS OF PAIN
Background: Pain is warning signal of the underlying pathology and is also essential for the diagnosis. Vanilla planifolia (VP) as per literature has analgesic activity. Analgesics like NSAIDs and Opioids are used for treating pain. Adverse effects limits their long-term use. Therefore, there is always a need of more effective and safe drugs. Objective: To evaluate the analgesic activity of ethano...
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STUDY OF ACAT RECEPTOR WITH HETEROCYCLIC COMPOUNDS FOR DRUG DESIGNING
ACAT enzyme is found in human body and it maintains cholesterol homeostasis in the cell. This leads to deposition of cholesterol in our body as cholesteryl esters. Freely deposited cholesterol in the membranes of the cells is cytotoxic. This deposition causes atherosclerosis, Alzheimer’s disease, Xanthelasma, etc. The first substrate for ACAT is both medium & long fatty acyl CoA. Therefore, ...
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