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ROLE OF DIFFUSION-WEIGHTED IMAGING IN THE EVALUATION OF INTRACRANIAL LESIONS
This study investigates the diagnostic utility of Diffusion Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) values in evaluating intracranial lesions. A cross-sectional analysis of 44 patients was conducted, examining age and gender distribution, histopathological types, and grades of brain tumors. The highest proportion of individuals (22.7%) was within the 0-10 age range, with ma...
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CHRONOTHERAPY THROUGH REGULATION OF CIRCADIAN RHYTHMS- AN OVERVIEW
The objective of chronotherapy is to optimize medical treatments taking into account the body's circadian rhythms. Drug delivery systems that precisely control the release rates or target drugs to a specific site have an enormous impact on the health care system. Over the past few years, pharmaceutical industry has focused its research in the development of various Chrono therapeutic delivery s...
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VARYING ANORECTAL DISORDERS: THEIR REMEDIES
Anorectal disorders are often perceived in surgery practice and often reside with pain with shifting vigour. Endeavour has been made to lessen pain and avoid ligature. Minuscule hospital stay with early return to work is the main aim of developing newer techniques in the management of anorectal diseases. Diverse modalities with the main tensity on surgical interceding for managing more common anor...
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PREDICTION OF POTENTIAL INHIBITORS SIMILAR TO REMDESIVIR (GS-5734) AGAINST 7BTF SARS COV 2 RNA DEPENDENT RNA POLYMERASE – AN IN-SILICO APPROACH
The novel Corona Virus Disease - 19 (COVID-19) is a Contagious disease spreading among Animals and Humans, a Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS CoV2). The First case was identified in Wuhan, China as the disease has unfolded worldwide to the continuing pandemic. It created more infected cases and deaths worldwide, creating an urge for newer drugs of manipulate the Ongoing Pandem...
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REMARKABLE ANTI-TRYPANOSOMA CRUZI ACTIVITY IN SELECTED SALVADORAN PLANT SPECIES
In Latin America, Chagas is one of the most prevalent diseases, and current chemotherapy with benznidazole and nifurtimox is ineffective in chronic phase. Therefore, the development of new drugs, especially for the chronic stage of the infection, is urgently needed. Performing an in-vitro anti-trypanosome assay, we analyzed 114 plant species from Salvadoran flora, resulting in 34 active plants aga...
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INVESTIGATION OF ANTI-SWARMING, ANTI-BIOFILM AND ANTI-QUORUM SENSING POTENTIAL OF SOME ORGANIC TEA OF DIFFERENT BRANDS FROM INDIA
The emergency to find a solution to multidrug resistance of bacteria due to the abuse of antibiotics leads to the search for new antibacterial pathways. Quorum sensing (QS), or bacterial cell to cell communication, is a cell-density-dependent bacterial response. It is mediated by hormone-like compounds called autoinducers (AIs). QS-dependent regulation of gene expression controls various phenotype...
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PERSISTENCE OF CANDIDA AURIS ON ELEMENTS USED FOR PERSONAL PROTECTION (LATEX GLOVES AND DISPOSABLE GOWN)
Candida sp. is currently associated with nosocomial infection; in this study, we aimed to determine the persistence of Candida auris on inanimate surfaces. Two test surfaces (latex gloves and disposable gown) were inoculated with two strains of Candida auris (clinical Ca1 and environmental H005913). The initial concentration of the inoculum was 108 UFC / mL, sampling was performed by rubbing a ste...
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EVALUATION OF ANTI-NOCICEPTIVE EFFECT OF ETHANOLIC EXTRACT OF VANILLA PLANIFOLIA SEEDS IN ANIMAL MODELS OF PAIN
Background: Pain is warning signal of the underlying pathology and is also essential for the diagnosis. Vanilla planifolia (VP) as per literature has analgesic activity. Analgesics like NSAIDs and Opioids are used for treating pain. Adverse effects limits their long-term use. Therefore, there is always a need of more effective and safe drugs. Objective: To evaluate the analgesic activity of ethano...
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EVALUATION OF ANTHELMINTIC ACTIVITY OF FICUS BENGHALENSIS BARK
The present study evaluated the Anthelmintic activity of Ficus benghalensis bark extract against Indian earthworm Pheretima posthuma and compared it with the standard drug Albendazole. The results showed that the extract exhibited significant Anthelmintic activity, as evidenced by the time of paralysis and time of death of worms. The extract also contained various phytochemical constituents, inclu...
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STUDY OF ACAT RECEPTOR WITH HETEROCYCLIC COMPOUNDS FOR DRUG DESIGNING
ACAT enzyme is found in human body and it maintains cholesterol homeostasis in the cell. This leads to deposition of cholesterol in our body as cholesteryl esters. Freely deposited cholesterol in the membranes of the cells is cytotoxic. This deposition causes atherosclerosis, Alzheimer’s disease, Xanthelasma, etc. The first substrate for ACAT is both medium & long fatty acyl CoA. Therefore, ...
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