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DISCOVERY OF INTERLEUKIN-6 INHIBITORY PROPERTIES OF THE COMPOUNDS DETECTED FROM METHANOLIC LEAF EXTRACTS OF PLECTRANTHUS AMBOINICUS (LOUR) SPRENG. THROUGH MOLECULAR DOCKING
Plectranthus amboinicus, locally called Karpooravalli in Tamil Nadu, India, is known for its various traditional therapeutic properties. Rheumatoid arthritis is a chronic autoimmune disease where uncontrolled inflammatory markers are released to induce bone damage and pain. In this study, the methanolic extract of P. amboinicus was characterized phytochemically and subjected to in-silico analysis ...
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MOLECULAR SCREENING FOR PREVALENCE OF ANTIBIOTIC-RESISTANT SALMONELLA SPP. IN DRINKING WATER SAMPLES FROM SLUM AREAS OF BHOPAL CITY, INDIA
The incidence of multiple antibiotic-resistant Salmonella spp. isolates in randomly collected potable water samples from 70 different slum area sites of Bhopal City, M. P. India, were investigated through a molecular approach.BSA media was used for isolation and CFU count of Salmonella spp. The DNA of representative Salmonella spp. Colors of each water sample were subjected to PCR to detect Amp, c...
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INSIGHTS INTO VARIOUS NOVEL SYNTHETIC STRTAEGIES FOR FLAVONE DEVELOPMENT: PHARMACOLOGICAL IMPORTANCE
Flavones make up one of the biggest subgroups of the secondary metabolite class of flavonoids, which has more than 9000 known structural variations. It is shown that they are present in practically all plant tissues naturally. In the literature, many flavone aglyca and their O- or C-glycosides have been described. Numerous potential uses exist for flavones due to their wide range of biological act...
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COMPARATIVE STUDY ON SAFETY AND EFFICACY OF THE DECOCTIONS OF SESAMUM INDICUM, NIGELLA SATIVA AND ITS COMBINATION ON POLYCYSTIC OVARY SYNDROME
This study investigated the efficacy and safety of three herbal decoctions for managing Polycystic Ovary Syndrome (PCOS), a condition affecting 2–26% of women globally and considered incurable within allopathic medicine and offers symptomatic treatments. This randomized, single-blind clinical trial, conducted between February 2022 and June 2024, enrolled 90 PCOS patients diagnosed by the Rotterd...
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ANTIDIABETIC POTENTIAL OF HYDROALCOHOLIC EXTRACT OF LEAVES OF NYCTANTHES ARBORTRISTIS IN ADRENALINE AND ALLOXAN-INDUCED DIABETIC RATS
Diabetes mellitus, a metabolic disorder, is a serious universal health problem. The incidence of the disease is increasing in the world in all ethnic groups. Various medicinal plants are conventionally used in the treatment or management of the disease. In this investigation, an attempt was taken to evaluate the antidiabetic property of hydroalcoholic extract of leaves of Nyctanthes arbortristis i...
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ROLE OF DIFFUSION-WEIGHTED IMAGING IN THE EVALUATION OF INTRACRANIAL LESIONS
This study investigates the diagnostic utility of Diffusion Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) values in evaluating intracranial lesions. A cross-sectional analysis of 44 patients was conducted, examining age and gender distribution, histopathological types, and grades of brain tumors. The highest proportion of individuals (22.7%) was within the 0-10 age range, with ma...
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IN-VITRO PHARMACEUTICAL QUALITY CONTROL TESTING: A COMPARITIVE STUDY OF JANAUSHADHI ORAL ANTIDIABETIC DRUGS WITH REPUTED BRANDS AVAILABLE IN INDIA
This study evaluates the pharmaceutical quality of metformin tablets, both generic and branded, available in India. Metformin, a primary medication for managing type 2 diabetes was chosen due to its widespread use and critical role in diabetes treatment. Using in-vitro methods compliant with Indian Pharmacopoeia standards, several quality control parameters were assessed, including hardness, friab...
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2D QSAR APPROACH TO DEVELOP NEWER GENERATION SMALL MOLECULES ACTIVE AGAINST SARS-COVID
We are in the half past of 2022, but still, we are facing the coronavirus pandemic situation. When a patient is hospitalized, only some FDA-approved drugs were administered to cure the patient. In treating coronavirus infection, nitazoxanide, granulocyte-macrophage colony-stimulating factor inhibitors, and various monoclonal antibodies are present. But all the molecules used in the treatment were ...
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INVESTIGATION OF ANTI-SWARMING, ANTI-BIOFILM AND ANTI-QUORUM SENSING POTENTIAL OF SOME ORGANIC TEA OF DIFFERENT BRANDS FROM INDIA
The emergency to find a solution to multidrug resistance of bacteria due to the abuse of antibiotics leads to the search for new antibacterial pathways. Quorum sensing (QS), or bacterial cell to cell communication, is a cell-density-dependent bacterial response. It is mediated by hormone-like compounds called autoinducers (AIs). QS-dependent regulation of gene expression controls various phenotype...
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PATTERN, CAUSALITY ASSESSMENT AND SEVERITY OF SUSPECTED ADVERSE DRUG REACTIONS REPORTED AT TERTIARY CARE TEACHING HOSPITAL
Background: Present study was conducted to evaluate pattern, causal association and severity of suspected Adverse Drug Reactions (ADRs) at a tertiary care teaching hospital in western India. Materials & Method: Spontaneous collection of suspected ADRs was done over a period of one year. Demographic data, suspected drug group/s, causal association, severity & preventability scale from the r...
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