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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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8.

CHRONOTHERAPY THROUGH REGULATION OF CIRCADIAN RHYTHMS- AN OVERVIEW

The objective of chronotherapy is to optimize medical treatments taking into account the body's circadian rhythms. Drug delivery systems that precisely control the release rates or target drugs to a specific site have an enormous impact on the health care system. Over the past few years, pharmaceutical industry has focused its research in the development of various Chrono therapeutic delivery s...

K. Kavitha * and N. H. Vidyashree

Department of Pharmaceutics, Nitte college of Pharmaceutical Sciences, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(5).1346-54

1346-1354

1505

1038

31.

INVESTIGATION OF ANTI-SWARMING, ANTI-BIOFILM AND ANTI-QUORUM SENSING POTENTIAL OF SOME ORGANIC TEA OF DIFFERENT BRANDS FROM INDIA

The emergency to find a solution to multidrug resistance of bacteria due to the abuse of antibiotics leads to the search for new antibacterial pathways. Quorum sensing (QS), or bacterial cell to cell communication, is a cell-density-dependent bacterial response. It is mediated by hormone-like compounds called autoinducers (AIs). QS-dependent regulation of gene expression controls various phenotype...

P. V. Hirapure *, S. A. Paranjape, T. V. Bind, K. K. Bawankar and V. J. Upadhye

Department of Biochemistry and Biotechnology, Dr. Ambedkar College Deekshabhoomi, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4620-27

4620-4627

1504

1045

18.

EVALUATION OF ANTHELMINTIC ACTIVITY OF FICUS BENGHALENSIS BARK

The present study evaluated the Anthelmintic activity of Ficus benghalensis bark extract against Indian earthworm Pheretima posthuma and compared it with the standard drug Albendazole. The results showed that the extract exhibited significant Anthelmintic activity, as evidenced by the time of paralysis and time of death of worms. The extract also contained various phytochemical constituents, inclu...

J. Hima Bindhu, R. Pradeep, N. Sneha, S. Tejaswi, P. Nikhil Patil and K. Ramanjaneyulu *

Department of Pharmaceutical Chemistry, Vishnu Institute of Pharmaceutical Education and Research, Narsapur Medak, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.15(1).166-69

166-169

1504

854

32.

PREDICTION OF POTENTIAL INHIBITORS SIMILAR TO REMDESIVIR (GS-5734) AGAINST 7BTF SARS COV 2 RNA DEPENDENT RNA POLYMERASE – AN IN-SILICO APPROACH

The novel Corona Virus Disease - 19 (COVID-19) is a Contagious disease spreading among Animals and Humans, a Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS CoV2). The First case was identified in Wuhan, China as the disease has unfolded worldwide to the continuing pandemic. It created more infected cases and deaths worldwide, creating an urge for newer drugs of manipulate the Ongoing Pandem...

K. Akila *, B. Pooja and R. Sharmila

Department of Biotechnology and Bioinformatics, Bishop Heber College (Autonomous), Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(11).4628-35

4628-4635

1503

822

23.

PATTERN, CAUSALITY ASSESSMENT AND SEVERITY OF SUSPECTED ADVERSE DRUG REACTIONS REPORTED AT TERTIARY CARE TEACHING HOSPITAL

Background: Present study was conducted to evaluate pattern, causal association and severity of suspected Adverse Drug Reactions (ADRs) at a tertiary care teaching hospital in western India. Materials & Method: Spontaneous collection of suspected ADRs was done over a period of one year. Demographic data, suspected drug group/s, causal association, severity & preventability scale from the r...

A. Shukla, P. Barot * and D. J. Dave

Department of Pharmacology, GMERS Medical College, Himmatnagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(12).5001-06

5001-5006

1503

912

14.

ROLE OF DIFFUSION-WEIGHTED IMAGING IN THE EVALUATION OF INTRACRANIAL LESIONS

This study investigates the diagnostic utility of Diffusion Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) values in evaluating intracranial lesions. A cross-sectional analysis of 44 patients was conducted, examining age and gender distribution, histopathological types, and grades of brain tumors. The highest proportion of individuals (22.7%) was within the 0-10 age range, with ma...

N. Shiva Prasath *, B. Spavan and R. Praveen

Department of Radiology, Sri Siddhartha Medical College, Tumkur, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.16(1).120-32

120-132

1502

802

17.

REMARKABLE ANTI-TRYPANOSOMA CRUZI ACTIVITY IN SELECTED SALVADORAN PLANT SPECIES

In Latin America, Chagas is one of the most prevalent diseases, and current chemotherapy with benznidazole and nifurtimox is ineffective in chronic phase. Therefore, the development of new drugs, especially for the chronic stage of the infection, is urgently needed. Performing an in-vitro anti-trypanosome assay, we analyzed 114 plant species from Salvadoran flora, resulting in 34 active plants aga...

U. G. Castillo, K. Alas, M. Mejía, G. Cerén, W. D. Castro-Godoy, R. M. Guerrero, J. Menjívar, M. L. Martínez, C. E. Arias, J. Nakajima-Shimada and M. J. Núñez *

Laboratorio de InvestigaciónenProductos Naturales (LIPN), Facultad de Ciencias Naturales y Matemática, Universidad de El Salvador, San Salvador Centro 1101, El Salvador.

DOI: 10.13040/IJPSR.0975-8232.16(5).1308-17

1308-1317

1502

826

7.

MACHINE LEARNING STRATEGIES FOR DRUG DISCOVERY AND DEVELOPMENT

This review paper provides a comprehensive overview of the role of machine learning (ML) in drug discovery and development within the pharmaceutical industry. It begins by outlining the foundational concepts of machine learning, highlighting its ability to enhance decision-making and improve accuracy through data analysis. The paper emphasizes the growing adoption of ML techniques across the pharm...

Muskan Verma, Shiv Hardenia * and Dinesh Kumar Jain

IPS Academy College of Pharmacy, Knowledge Village, Rajendra Nagar, A.B. Road, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.16(5).1194-08

1194-1208

1502

681

21.

EVALUATION OF THE ANTIHYPERTENSIVE ACTIVITY OF R-(+)-PULEGONE IN L-NAME INDUCED HYPERTENSIVE WISTAR RATS

Objectives: The present study was aimed to assess the anti-hypertensive effect of PLG in L-NAME-induced hypertensive rats. Methods: Wistar rats of 200-240g were given L-NAME (40 mg/kg body weight/day/p.o.) in drinking water daily for 4 weeks to induce hypertension. Rats were randomly divided into six groups: control, L-NAME control, Verapamil (20 mg/kg, p.o.), and PLG (5, 10, and 20 mg/kg, p.o.)...

S. H. Sawant * and G. A. Bale

Department of Pharmacology, STE’s, Sinhgad Institute of Pharmacy, Narhe, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(10).4000-10

4000-4010

1500

830

34.

EVALUATION OF ANTI-NOCICEPTIVE EFFECT OF ETHANOLIC EXTRACT OF VANILLA PLANIFOLIA SEEDS IN ANIMAL MODELS OF PAIN

Background: Pain is warning signal of the underlying pathology and is also essential for the diagnosis. Vanilla planifolia (VP) as per literature has analgesic activity. Analgesics like NSAIDs and Opioids are used for treating pain. Adverse effects limits their long-term use. Therefore, there is always a need of more effective and safe drugs. Objective: To evaluate the analgesic activity of ethano...

Avinash Sarak, Jayshree Dawane *, Vijaya Pandit and Trupti Patil-Bhole

Department of Pharmacology, Bharati Vidyapeeth Deemed To Be University Medical College, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(5).2417-21

2417-2421

1500

788