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COMPARATIVE STUDY BETWEEN RESULTS OF RETROGRADE INTRAMEDULLARY NAILING (RN) VS LOCKED PLATING (LP) IN TREATMENT OF DISTAL FEMUR FRACTURES: A PROSPECTIVE ANALYSIS
Introduction: Distal femoral fractures are among challenging orthopaedic injury constituting 0.4% of all fractures. Despite recent evaluation in operating techniques and surgical implants, debate continues around the choice of implant for various type of distal femur fractures. Method and Material: In prospective randomized study from 2020 to 2022, analysis of 40 patients was done out of which 20 ...
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ASSESSMENT OF FATIGUE IN DIALYSIS [PERITONEAL AND HEMODIALYSIS] AND NON- DIALYSIS PATIENTS OF CHRONIC KIDNEY DISEASE
Background: Fatigue is a common symptom in patients with advanced kidney disease, with implications for quality of life and clinical outcome. Fatigue is one of the most frequent complaints of dialysis patients and is associated with impaired health related quality of life (HRQOL). Aim: To monitor and measure the severity of fatigue in dialysis and non-dialysis patients of chronic kidney disease. M...
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RP-HPLC BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN AND LEVOTHYROXINE IN HUMAN PLASMA- DRUG INTERACTION STUDIES
A simple, sensitive, robust and specific high performance liquid chromatographic (HPLC) method was developed and validated for the simultaneous determination metformin and levothyroxine in human plasma. In the current study, the analysis was performed on Phenomenex Luna 5µ C18 100A (250 x 4.6mm, 5 micron) column using acetonitrile: methanol: 0.03M phosphate buffer (pH 2- 3.5) 50:10:40 v/v/v as mo...
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NITISINONE IN HUMAN PLASMA: UPLC-MS/MS ASSAY VALIDATION AND STABILITY STUDIES
A simple, precise, and rapid ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS method for determination of nitisinone in 20 µl human plasma was developed and validated. Nitisinone 6C13 was used as an internal standard (IS). Chromatographic analysis was performed on an Atlantis dC18 column (2.1 x 100 mm, 3 µm) using a mobile phase consisting of methanol and...
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A PROSPECTIVE COMPARATIVE STUDY OF LETROZOLE AND CLOMIPHENE CITRATE IN OVULATION INDUCTION IN WOMEN HAVING PCOS
Introduction: Clomiphene citrate (CC) is the primary drug of choice for ovulation induction in PCOS but resistance to ovarian stimulation is frequent observation with CC. Letrozole (Let), an Aromatase Inhibitor (AI) induces folliculogenesis by releasing hypothalamo-pituitary axis from tonic inhibitory effect of estrogen. Aim: To compare the rate of folliculogenesis, number of follicle count, ovula...
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OVERVIEW OF ORAL DISPERSIBLE TABLETS
The need to deliver pharmaceuticals to patients quickly and with minimal side effects has driven pharmaceutical companies to invest in the development of novel drug delivery systems. Solid dose forms, such as pills, are difficult for pediatric and geriatric patients to swallow. The best treatment for this issue is a mouth dissolving pill that dissolves or disintegrates quickly in the oral cavity. ...
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CHRONOTHERAPY THROUGH REGULATION OF CIRCADIAN RHYTHMS- AN OVERVIEW
The objective of chronotherapy is to optimize medical treatments taking into account the body's circadian rhythms. Drug delivery systems that precisely control the release rates or target drugs to a specific site have an enormous impact on the health care system. Over the past few years, pharmaceutical industry has focused its research in the development of various Chrono therapeutic delivery s...
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FORMULATION AND EVALUATION OF TASTE MASKED ORAL DISINTEGRATING TABLET OF LACOSAMIDE
Lacosamide is an antiepileptic bitter drug used to treat partial onset seizure. The aim of the work was to mask the taste of lacosamide and then formulation and evaluation of tablet. Taste was masked using spray dryer. Oral disintegrating tablet was prepared using 3 superdisintegrants Sodium starch glycolate, Crosscarmellose sodium and Polyplasdone XL10. Out of these polyplasdone showed quick disi...
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A REVIEW: MOUTH DISSOLVING TABLET
The demand for Mouth Dissolving Tablet has been increasing for the last decade particularly in geriatric, peadiatric and patient with some sort of disabilities in swallowing. Mouth dissolving tablets are those tablets which when placed in mouth get dissolved rapidly in saliva without the need of liquid and can be swallowed. European pharmacopeia adopted the term Oro-dispersible tablet for MDTs. Mo...
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METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF NICOTINAMIDE AND METRONIDAZOLE IN GEL USING UV-SPECTROPHOTOMETER
An easy, precise and accurate spectroscopic technique for the simultaneous estimation of nicotinamide and metronidazole in semi-solid dosage form and in bulk form has been developed. The present method involves the addition of 0.1M hydrochloric acid solution, followed by dilution with water and subjecting the resulting solution to UV spectroscopic assessment. Absorption maximum was found to lie at...
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