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ELECTROCEUTICAL APPROACHES IN PARKINSON’S DISEASE MANAGEMENT: A REVIEW OF EFFICACY, SAFETY, AND LIMITATIONS
The utilisation of electroceuticals in the treatment of Parkinson's disease is the predominant topic of discussion in this review. Electroceuticals, which are frequently referred to as "bioelectronics medicine," are the result of the utilisation of electrical impulses for the goal of therapeutic treatment. It has been investigated if electroceuticals could serve as an alternative or adjuvant to th...
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FORMULATION AND EVALUATION OF EFFERVESCENT GRANULES PREPARED BY USING MORINGA OLEIFERA (LAM) LEAF EXTRACT
Moringa oleifera leaves, have a high antioxidant content, which is beneficial for overcoming free radicals in the body. The leaves contents have the potential to be developed into a functional drink in the form of effervescent granules. The important aspects influencing the acceptability of granule is the type and ratio of the effervescent agent. In this study, citric acid and sodium bicarbonate w...
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TOPICAL APPLICATION OF BACTERIOPHAGES FOR THE TREATMENT OF WOUND INFECTIONS:
Wound infections persist as a significant and persistent challenge within the realm of healthcare, posing numerous detrimental consequences that extend far beyond the affected individuals. These infections, characterized by the infiltration of harmful microorganisms into wounds, encompass a multifaceted predicament that engenders slower healing periods, heightened morbidity rates, and an onerous f...
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MULTIFACETED APPLICATION OF CURCUMIN IN TRADITIONAL HEALTHCARE SYSTEM
Curcumin, a substance produced from the root of the plant Curcuma longa, has been used for thousands of years in Ayurveda and traditional Chinese medicine to treat a variety of inflammatory disorders. Curcumin, the turmeric key ingredient responsible for this function, was discovered over two centuries ago. Curcumin exerts its effects via altering a number of crucial molecular targets, including t...
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BIOEQUIVALENCE STUDY OF LUMEFANTRINE RECTAL ENEMA AND THE COMMERCIALLY AVAILABLE GENERIC ORAL SUSPENSION. A PILOT STUDY
Children under five years of age, with severe or cerebral malaria, cannot consume oral medication especially if they are vomiting or are unconscious. In such situations they are given an injectable drug until they can tolerate oral medication. The situation is bad in Sub-Saharan Africa, especially in rural areas as children are sometimes referred to the closest referral health care facility for pr...
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AMELIORATIVE POTENTIAL OF MORINGA OLEIFERA AQUEOUS LEAF EXTRACT ON PARACETAMOL-INDUCED TESTICULAR TOXICITY IN ADULT MALE SPRAGUE-DAWLEY RATS
Testicular toxicity has been associated with long-term paracetamol usage. Moringa oleifera is known to eliminate toxins from organs and restore functionality. This study seeks to ascertain the potency of moringa in ameliorating paracetamol-induced testicular toxicity. Forty nine (49) Sprague-Dawley rats were randomly assigned into seven (7) groups composed of 7 rats each treated for 5 weeks. One g...
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A SYSTEMIC REVIEW ON THE PATHOGENESIS OF IBD, ALTERATIONS IN GUT MICROBIAL ECOLOGY OBSERVED IN IBD, ROLE OF CYTOKINES (TNF-, INF-, IL-1, IL-6, IL-4, IL-5, IL-10) IN IBD AND RECENT THERAPEUTIC STRATEGIES
Inflammatory bowel disease (IBD) is a chronic inflammatory illness of the gastrointestinal tract that consists of Crohn's disease and ulcerative colitis. The pathogenesis of IBD is multifactorial and involves a complex interplay between genetic, environmental, and immunological factors. A comprehensive literature search was conducted using relevant databases, such as PubMed, Scopus, and Web of Sci...
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IN-SILICO STUDY: MYRICETIN FROM THE STEM BARK OF SYZYGIUM CUMINI INHIBITS THE GROWTH OF NON-SMALL CELL LUNG CANCER CELLS THROUGH THE EGFR PATHWAY
Around the world, cancer frequently leads to death. Lung cancer is the primary cause of cancer-related deaths globally. Through in-silico analysis, this study sought to assess the anticancer effectiveness of myricetin on human lung cancer cells. The study's goal is to assess how well myricetin adheres to the Lipinski rule of 5. To evaluate the ADMET properties (Absorption, Distribution, Metaboli...
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POSTOPERATIVE PAIN MANAGEMENT BY FENTANYL VS DEXMEDETOMIDINE AS AN ADJUVANT WITH ROPIVACAINE BY TRANSVERSUS ABDOMINIS PLANE (TAP) BLOCK IN INFRA UMBILICAL SURGERIES UNDER SPINAL ANAESTHESIS: A COMPARATIVE STUDY
Introduction: The analgesia effect of anesthetic drugs namely Ropivacaine, can further be enhanced with adjuvants. For postoperative pain management in infra-umbilical surgeries, Ropivacaine with an adjuvant can be used through a Transversus Abdominis Plane (TAP) block, which is a simple and clinical anatomical landmark procedure, suitable in remote areas without advanced modern technical tools. A...
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STABILITY STUDY OF NEWLY FORMULATED EMULSION WITH MARKETED FORMULATION
The aim of the article is to formulate and evaluate emulsion also perform comparative study with marketed formulation. Emulsion is a heterogeneous system consisting of at least one immiscible liquid dispersed in another in the form of droplets. Emulsion is prepared with castor oil and liquid paraffin. One marketed formulation was taken for comparison. Identification tests, evaluation tests and sta...
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