Most Popular
AN UPDATED STATUS OF ALANINE RACEMASE INHIBITORS: A REVIEW
Enzyme Alanine racemase is well known for performing a predominating role in mycobacterium cell wall synthesis. D-alanine provided by Alanine racemase serves as a peptidoglycan precursor, utterly vital for maintaining the growth and integrity of the cell wall. The lipid-rich mycobacterium cell wall is prevalent amidst prokaryotes with immense potential of becoming a therapeutic target for new drug...
1521
1067
A RETROSPECTIVE PRESCRIPTION AUDIT STUDY IN OUT PATIENT DEPARTMENT OF A TERTIARY CARE HOSPITAL IN SOUTHERN RAJASTHAN
Background: Prescription audit is an effective way to raise the standard of prescriptions. WHO core prescribing indicators are established and trustworthy tool for assessing the quality of prescriptions. So, we used WHO-recommended core prescribing indicators to assess the prescription pattern of treating physicians. Methods: A retrospective observational study was done. A total of 632 prescriptio...
1521
965
SCIENTIFIC CORROBORATIVE EVIDENCE OF ANTHELMINTIC ACTIVITY OF CITRUS MAXIMA LEAF: A TRADITIONALLY USED HERB OF NORTHEAST INDIA
Citrus maxima, a well-known citrus species, is an important Assam plant used to treat various disorders by many communities in Northeast India. The local tribes of Northeast India have been using the leaves of C. maxima to eradicate worm infestations since time immemorial. Till date, no scientific research has been conducted on this plant to determine its anthelmintic potential. As a result, an ex...
1521
868
QUANTITATIVE EVALUATION OF IMPURITIES G AND S IN VALACICLOVIR HYDROCHLORIDE HYDRATE ACTIVE PHARMACEUTICAL INGREDIENT USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYTICAL METHOD
Current work makes known that Liquid Chromatography-Mass Spectrometry (LC-MS) method development and validation for the impurity G (N, N -dimethylpyridin-4-amine) and impurity S (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl) methoxy] ethyl N-[1,1-dimetylethoxy) carbonyl]-L-valinate) in Valaciclovir Hydrochloride Hydrate active pharmaceutical ingredient (API). The developed LC-MS analytical method i...
1520
1159
PREDICTORS OF POLYPHARMACY PRESCRIPTION IN TYPE 2 DIABETES MELLITUS PATIENTS: A CROSS-SECTIONAL SURVEY
Polypharmacy is defined as the “prescription, administration, or use of more medications than are clinically indicated. It can lead to drug-drug interactions and result in adverse drug events. Therefore, this study aimed to determine the prevalence of polypharmacy and factors that independently predict polypharmacy prescription. 200 Type 2 Diabetes Mellitus (T2DM) patients were enrolled and anal...
1520
816
ANALYSIS AND REPORTING OF ADVERSE DRUG REACTIONS AT A TERTIARY CARE TEACHING HOSPITAL IN MEWAT REGION OF NORTHERN INDIA
Introduction: Adverse drug reactions (ADRs) poses an unforeseeable menace associated with all the prescribed medicines. Thus, ADRs are monitored and assessed on a large scale in our country by the Pharmacovigilance Programme of India through adverse drug reaction monitoring centres (AMCs). Objectives: This study was done to assess the pattern of ADRs reported in a tertiary care teaching hospital i...
1520
872
COMPARISON OF SARS CoV-2 RT-PCR TEST WITH RAPID ANTIGEN DETECTION KIT AND OTHER NON SPECIFIC TEST
Background: Severe Acute Respiratory Syndrome Corona Virus Disease 2019 (COVID-19) is responsible for the COVID-19 pandemic causing respiratory illness worldwide. Hence there is an urgent need for simple, rapid, and accurate tests for diagnosis. Performance characteristic of Rapid Antigen detection test for identifying sensitivity and specificity with gold standard Real-Time Polymerase Chain React...
1519
808
EVALUATION OF ANTIDIABETIC, ANTIOXIDANT, AND PHYTOCHEMICAL ANALYSIS OF CEREUS JAMACARU D.C. SEED EXTRACT
Central and eastern Brazil is home to the cactus species Cereus jamacaru, also called mandacaru or cardeiro. It frequently reaches a height of 6 metres. For animal feed, a kind without thorns is utilized. The most typical type is quite thorny; however, if the thorns are The native Brazilian cactus Cereus jamacaru D.C., also known as "mandacaru," grows naturally in the Caatinga biome and is charact...
1519
872
SCREENING OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF GLORIOSA SUPERBA IN RODENTS
Background: Traditionally Gloriosa superba is being used as a medicinal plant in outskirts of belagavi, we evaluated and compared the analgesic and anti-inflammatory activities of hydroalcoholic extract of dried aerial parts (rhizomes) of G. superba with standard drugs. Methods: This experimental animal study was carried out in the Research Laboratory, Department of Pharmacology, BIMS, Belagavi. P...
1518
912
IN-SILICO IDENTIFICATION OF NEWER POTENTIAL LEMUR TYROSINE KINASE 3 INHIBITORS FOR THE TREATMENT OF BREAST CANCER
Breast cancer refers to cancer emerging from breast tissue, commonly from the lobules that supply the ducts with milk or from the inner linings of milk ducts. Due to the mutation of DNA or RNA from the normal cells and abnormal genes when inherited, cancer cells are evolved. LMTK3 (lemur tyrosine kinase 3) has emerged as an important player in breast cancer, contributing to the advancement of dise...
1518
935