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POTENTIAL ANTI-ULCER ACTIVITY OF SIDDHA POLY HERBAL FORMULATION PANCHA MOOLA KUDINEER CHOORANAM: INSIGHTS FROM MOLECULAR DOCKING
The Siddha medicine system, predominantly practiced in South India, encompasses a diverse range of medicinal formulations. Among them, Pancha Moola Kudineer Chooranam (PMKC) from the Therayar Maha Karisal literature is claimed to be effective against ulcers. Helicobacter pylori, causes gastric and duodenal ulcers through various transmission routes. It colonizes the duodenal epithelial cells, lead...
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IN-SILICO STUDIES ILLUSTRATE THE ONCOGENIC POTENTIAL OF AN ATPASE PROTEIN NSF
Cancer is a complex and life-threatening disease characterized by abnormal cell growth. Several AAA+ ATPases are involved in the oncogenic pathways, however, the role of an ATPase protein i.e. N-ethylmaleimaide-Sensitive Factor (NSF) was unclear. Therefore, we performed systematic bioinformatics analysis to predict the prospect of NSF as a cancer biomarker. NSF is found to be upregulated in some ...
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BOERAVINONE B AND CHEBULINIC ACID AMELIORATE ASPARTAME INDUCED TOXICITY IN HEPG2 CELLS BY REGULATING CELL DEATH PATHWAYS
Aspartame is the most common artificial sweetener which is known to induce oxidative stress. Our goal was to determine whether Boeravinone B and Chebulinic acid protect HepG2 cells against Asp-induced oxidative stress in HepG2 on a multifarious level. In this investigation we have addressed ameliorative role of BB and CA in due course of Asp exposure by evaluating biochemical and molecular paramet...
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THE INCIDENCE AND NATURE OF DRUG-RELATED PROBLEMS AMONG INPATIENTS IN A TERTIARY CARE HOSPITAL IN NORTHERN INDIA: A PROSPECTIVE STUDY
The advancement of drug therapy has undoubtedly elevated patient care standards. However, it has also given rise to an increase in Drug-Related Problems (DRPs), which can significantly disrupt health outcomes. In an 18-month prospective observational study involving 2,000 patients, we meticulously assessed DRPs using the Hepler and Strand classification system. These DRPs encompassed a range of is...
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PHYTOCHEMICAL ANALYSIS, ELEMENTAL CONTENT, AND FIBROBLAST PROLIFERATION ACTIVITY OF THE HYDRO-ETHANOLIC EXTRACT OF MORINGA OLEIFERA LAM LEAVES
Moringa oleifera is one plant that is multi-purposefully used for the prevention and treatment of numerous diseases. This study analyzed the phytochemical and elemental contents of M. oleifera leaf extract, and evaluated its effect on fibroblast proliferation, which is crucial for wound healing. M. oleifera leaf samples were collected, identified, and extracted using solvents of different polariti...
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A COMPARATIVE ANALYSIS OF GLASGOW COMA SCALE SCORE WITH FULL OUTLINE OF UNRESPONSIVENESS SCORE IN ASSESSMENT OF PATIENTS WITH TRAUMATIC HEAD INJURY IN INTENSIVE CARE UNIT: A TERTIARY CARE CENTRE STUDY
Background: Neurological assessment of traumatic brain injury patients is of prime importance as it affects the therapeutic and prognostic decisions. GCS (Glasgow Coma Scale), a well recognised and often used scoring system in such cases has some drawbacks. We compared FOUR score (Full Outline of Unresponsiveness) with GCS with an objective to test its validity as an alternative to assess the seve...
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PATTERN OF DRUGS PRESCRIBED FOR ELDERLY PATIENTS BY PRIVATE PRACTITIONERS OF MODERN MEDICINE IN LUCKNOW, THE CAPITAL OF UTTAR PRADESH
Changes in drug prescribing-pattern in different groups of population and age-related pathophysiological changes may result in altered response of drugs and need proper monitoring to avoid adverse consequences. Polypharmacy is very common in elderly which further increases risk for unwanted effects. Moreover, physicians should be more familiar with the common problems and diseases occurring amongs...
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DEVELOPMENT AND VALIDATION OF HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHODFOR LAFUTIDINE IN BULK AND TABLET DOSAGE FORM
A simple, precise and sensitive High Performance Liquid Chromatographic method has been developed for the quantitative estimation of Lafutidinein bulk and tablet dosage form. The method was performed on Silicagel 60 F254 aluminum plate. A Camag HPTLC system comprising of Camag Linomat IV semiautomatic sample applicator, Camag TLC Scanner 3, Camag twin-trough chamber (10×10 cm) and Camag CATS 4 so...
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DEVELOPMENT AND VALIDATION OF THE HPTLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF RAMIPRIL AND HYDROCHLOROTHIAZIDE IN SOLID DOSAGE FORM
Ramipril is an angiotensin-converting enzyme inhibitor and is used in treating high blood pressure. Hydrochlorothiazide is a diuretic drug that increases urine output. High-Performance Thin-Layer Chromatography is a sophisticated form of thin-layer chromatography which is a separation technique and is used in various bioavailability studies to study marketed formulations as well as novel therapeut...
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OPTIMIZATION AND DEVELOPMENT OF TOPICAL METAL ION – CONTAINING ANTIBACTERIAL CREAM AND GELS
Normally and often skin infections present therapeutic challenges to practitioners and researchers due to the growing concern regarding multi-drug resistant bacterial, Viral, and Fungi Strains. The Antibacterial properties of zinc sulphate and copper sulfate are well known and have been investigated for many previous years. However, the synergistic effect between both metal ions as antibacterial i...
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