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DE RITIS RATIO OF COVID-19 PATIENTS ADMITTED DURING FIRST, SECOND AND THIRD WAVE
Background: To date, the 2019 novel coronavirus pneumonia (COVID-19) is the greatest public medical issue in the world. World Health Organization (WHO) declared this outbreak a “public health emergency of international concern” on January 31, 2020. Therefore, it bodes well to look for a potential biomarker that could quickly and effectively distinguish serious cases early. Of the total confirm...
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EVALUATION OF ANTICANCER POTENTIAL OF METHANOLIC EXTRACT OF PETALS OF CHRYSANTHEMUM MORIFOLIUM AGAINST HUMAN LIVER CANCER CELL LINE (HEPG2)
Chrysanthemum morifolium is commonly known as chrysanthemum. It has been widely used in traditional medicine due to its various therapeutic effects. Past studies have shown that chrysanthemum extracts possess significant anticancer activity against breast, prostate, and colon cancer cells. The active compounds in chrysanthemum extracts such as flavonoids, sesquiterpenes, and triterpenoids have bee...
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EXTRACTION ISOLATION CHARACTERIZATION AND PHARMACOLOGICAL SCREENING OF AEGLE MARMELOS FOR ANTIASTHMATIC ACTIVITY
Aegle marmelos (L) Correa also known as Bale, belongs to family Rutaceae. The plant is used to treat several diseases like bronchitis, asthma, malarial, astringent, laxatives, digestive and febrifuge. Leaves are used as antipyretic, antimicrobial, antidiabetic, antihistaminic, anti-inflammatory, antioxidant, and hyperlipidaemic activity. The plant contains diterpenoids, triterpenoids, and phenolic...
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ACYCLOVIR LOADED GELATIN BIODEGRADABLE NANOPARTICLES: FORMULATION, OPTIMIZATION, CHARACTERIZATION, AND IN-VIVO EVALUATION
Acyclovir has a ratified antiretroviral effect for Herpes simplex virus type 1 (HSV-1), HSV-2, Varicella zoster virus (VZV), Herpesvirus simiae and to a minor extent, Epstein-Barr virus (EBV). The oral bioavailability of acyclovir is indigent, with only 15%–30% of the oral formulations' vitality absorbed. To baffle the issue of insignificant bioavailability, acyclovir was formulated into biodegr...
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HYDROETHANOLIC EXTRACT OF CEDRELA ODORATA IMPROVES HYPERLIPIDEMIA AND REDUCES THE ACTIVITY OF ENZYMES IN THE LIVER OF ETHANOL-INDUCED HYPERLIPIDEMIC RATS
Hydroethanolic extract of the Cedrela odorata (HeECo) showed hypolipidemic potential in diabetic rats. Thus, we evaluate the hypolipidemic effect and the mechanism of the action of the HeECo in a rat model of ethanol-induced hyperlipidemia. Male Wistar rats are divided: normolipidemic (C); hyperlipidemic non-treated (Hl); hyperlipidemic treated with HeECo 500 mg.kg-1 (HlCo); and hyperlipidemic tre...
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COGNITION ENHANCING ABILITY OF A POPULAR GREEN LEAFY VEGETABLE- CHENOPODIUM ALBUM: IN-VITRO AND IN-VIVO CORROBORATION
Oxidative stress and cholinergic deficit are major culprits of cognitive impairment. Intake of green leafy vegetables - rich in antioxidant phytoconstituents- strongly correlates with memory-preserving capacity. Our earlier work showed that hydromethanol (HM) extract of Chenopodium album (a common leafy vegetable) had strong acetylcholinesterase inhibitory and antioxidant activity in-vitro. The ob...
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EVALUATION OF ANTILIPIDEMIC POTENTIALS OF PHASEOLUS VULGARIS ON ALLOXAN-INDUCED DIABETIC RATS
Healthy diet has been known to play a key role in managing and preventing diseases. The health benefits of consuming common beans (Phaseolus vulgaris) are widely acknowledged and are ascribed mostly to their high dietary fiber contents and polyphenols. Various animal experimental studies have shown that polyphenol in common beans has antioxidant properties and other biological activities. This stu...
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FORMULATION AND EVALUATION OF VALSARTAN NANO-EMULSION FOR ITS TRANSDERMAL EFFICACY
Valsartan is a selective angiotensin type I receptor agonist that has been used in the treatment of hypertension disease. The development of a thermodynamically stable and infinitely dilutable nanoemulsion (O/W) of valsartan with surfactant at a low concentration that can enhance its solubility and stability came about as a result of our investigation into the effectiveness of nanoemulsion as a ca...
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RAPID ESTIMATION OF ESCITALOPRAM IMPURITIES IN MULTIPLE BRANDS USING COMPREHENSIVE STABILITY INDICATING RP-HPLC METHOD
This study aimed regarding application of comprehensive stability-indicating analytical method for estimation of Escitalopram impurities in multiple brands of pharmaceutical dosage forms using reverse phase high-performance liquid chromatography. The comprehensive stability-indicating analytical method applied utilized an isocratic mode with a C18 column. The mobile phase comprised a phosphate buf...
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ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITY OF GREWIA HIRSUTA VAHL. LEAVES
Objectives: Grewia hirsuta Vahl. is a shrub explored for medicinal applications. It has anti ageing, boosting immunity, prevents loss and grey hair etc. Ethnopharmacological data suggests that the plant is extensively used as a nerve tonic and to enhance the cognitive properties. The basis of these medicinal uses seems to be antioxidant and anti cholinesterase activity. In order to establish the s...
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