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PHYTOCONSTITUENT ANALYSIS AND IN-VITRO ANTI-INFLAMMATORY ACTIVITIES OF PLANTS SOURCES
Bioactive compounds are secondary plant metabolites and are found in small amounts in plants, fruit, vegetables, and edible oils; they have health benefits and provide us an alternative search for drugs or medicines and followed by the minimum side effects. There are various bioactive assays for measuring the functional activities of bioactive compounds, such as phytochemical assays and anti-infla...
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INTRICACIES IN TRISOMY 21; ROLE OF CERTAIN POLYPHENOLS IN COGNITIVE DYSFUNCTION ALLIED WITH NEURODEGENERATION
One of the most prominent issues with Down Syndrome (DS) individuals is the cognitive deficits that come with early-onset Alzheimer’s disease (AD). Numerous mechanisms are accountable for neurodegeneration and declined cognition, including impairment in neurogenesis leading to hypocellularity in the cortex, cerebellum and hippocampus, altered dendritic morphology, and altered synapses plasticity...
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POLYPHARMACY AND POTENTIAL DRUG – DRUG INTERACTIONS IN ELDERLY PATIENTS OF RURAL POPULATION ATTENDING GENERAL MEDICINE DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL
Aim and Objective: The present study was done to assess the prevalence of polypharmacy and to study its consequences in elderly people. Methodology: The study was prospective observational study, done in 500 elderly patients attending the Department of General Medicine in rural tertiary care teaching hospital in Telangana. The study was done for a period of 6 months from April 2019 to September 20...
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TO STUDY THE ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF OIL FROM LEAVES OF CAMELLIA SINENSIS L. IN EXPERIMENTAL ANIMAL MODELS
The present study has been conducted to search out the anti-oxidative and anti-inflammatory potential of leaves of Camellia sinensis L. oil (Tea oil, TO). Forty-eight rats were included for 14 days experiment namely: Group I was normal to control, Group II was vehicle control, and Group III to VIII rats were subjected to paracetamol at the dose of 15 mg/ kg body weight/day to induce oxidative st...
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MORINGA OLEIFERA (MO) SEED CATALYZED THE SYNTHESIS OF BENZIMIDAZOLE DERIVATIVES
A simple, one-pot, and efficient method for the synthesis of benzimidazole derivatives via the condensation of o-phenylenediamine and substituted aromatic aldehydes in the presence of Moringa oleifera (MO) seed extract acts as a biocatalyst under microwave irradiation. The method provides several advantages such as simple operation, clean reaction ways, and high to the excellent yield of product. ...
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FORMULATION AND EVALUATION OF MOXIFLOXACIN TASTE-MASKED CHEWABLE TABLES FOR PEDIATRIC TUBERCULOSIS
Moxifloxacin (MOX) is a second-line treatment for drug-susceptible and multidrug-resistant tuberculosis (MDR TB). MOX has poor patient compliance due to taste and odour concerns, particularly in the pediatric population. MOX taste-masked chewable tablets were developed by direct compression method using mannitol, aspartame, and sucralose as sweetening agents and lemon and peppermint flavor as flav...
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SYNTHESIS AND ANTIMICROBIAL STUDY OF METAL COMPLEXES OF SM (III), EU (III) AND ASYMMETRICAL LIGAND DERIVED FROM DEHYDROACETIC ACID
Tetradentate Schiff bases are synthesized from o-phenylenediamine, 5-bromo Salicylaldehyde, and 3-Acetyl-6-methyl-pyran-2, 4-dione, and then its colored complexes of Sm (III) and Eu (III) are formed. The structure of ligand and complexes are characterized by elemental analysis, magnetic susceptibility, thermal analysis, X-ray diffraction, 1H-NMR, mass, IR, UV-visible spectra, and conductometry. TG...
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COMPARATIVE PHYSIOLOGICAL AND MOLECULAR RESPONSES OF A COMMON AROMATIC INDICA RICE CULTIVAR TO HIGH SALINITY WITH NON-AROMATIC INDICA RICE CULTIVAR
With a threshold of 3 DSM-1, rice is one of the crops that are most sensitive to salt. Salinity in agricultural areas is primarily brought on by the overuse of irrigation water that is overly salty. The early vegetative and seedling stages of rice are the most vulnerable to salt stress, followed by the reproductive phases. When osmotic stress inhibits root water uptake, too much salt in the soil h...
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SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF NOVEL 1-(PYRIDINE-2YL)-1H-PYRAZOLE-5-CARBOXAMIDE DERIVATIVES
Introduction: Bacterial infections are associated with significant morbidity and mortality globally. This scenario is further complicated by the development of antibiotic resistance, which has an adverse impact on the world economy by increasing the treatment cost and prolonging the hospital stay. It also requires use of reserve antibiotics which have higher toxicity. Hence, new antibacterial drug...
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MOLECULAR DOCKING ANALYSIS OF COMPARISON BETWEEN INDOLE ALKALOID COMPOUNDS FROM CATHARANTHUS ROSEUS WITH THE TARGETS FOR BREAST CANCER
Endocrine-disrupting chemicals are environmental pollutants that have been associated with a wide range of diseases, including breast cancer, the most prevalent cancer in women worldwide, according to the WHO. Among the different cancers affecting the female population, breast cancer has the highest incidence and mortality rate. The incidence of breast cancer is 100 times higher in women than in m...
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