C-phycocyanin (C-PC) is a biliprotein found in edible blue-green algae. Its anti-cancer, anti-inflammatory, anti-proliferative and anti-oxidant activities has been evidenced by many in vitro and in vivo studies. Anti-inflammatory activity of C-PC demonstrated by free radical scavenging, inhibition of DNA damage, and decreased ROS. Here, the effects of C-PC on cytotoxicity and cell signaling throug...
3D-QSAR AND CONTOUR MAP ANALYSIS OF TARIQUIDAR ANALOGUES AS MULTIDRUG RESISTANCE PROTEIN-1 (MRP1) INHIBITORS
One of the major obstacles to the successful chemotherapy towards several cancers is multidrug resistance of human cancer cells to anti-cancer drugs. An important contributor to multidrug resistance is the human multidrug resistance protein-1 transporter (MRP1), which is an efflux pump of the ABC (ATP binding cassette) superfamily. Thus, highly efficacious, third generation MRP1 inhibitors, like t...
DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROMETRIC METHOD FOR ESTIMATION OF WATER SOLUBLE VITAMIN RIBOFLAVIN
The present study describes a simple, accurate, precise and cost effective UV-Visible spectrophotometric method for the estimation of Riboflavin raw material. The Riboflavin is water soluble vitamin, so the solvent used throughout the experiment was 0.1N NaOH, the absorption maxima of drug was found at 445 nm. Beer’s law was obeyed in the range of 5ppm-30ppm. the developed method was successfull...
Cucumis sativus (Cucumbers) have not received as much press as other vegetables in terms of health benefits, but this widely cultivated food provides us with a unique combination of nutrients. At the top of the phytonutrient list for cucumbers are its cucurbitacins, lignans, and flavonoids. These three types of phytonutrients found in cucumbers provide us with valuable antioxidant, anti-inflammato...
PRELIMINARY PHYTOCHEMICAL ANALYSIS AND THIN LAYER CHROMATOGRAPHY OF THE EXTRACTS OF EXCOECARIA AGALLOCHA L.
Purpose: The focus of the present paper was a preliminary phytochemical and TLC analysis of the various extracts (root, stem, and leaf) of the mangrove plant Excoecaria agallocha L. Methods: Phytochemical analysis was carried out using the standard phytochemical assays. TLC analysis of the petroleum ether and chloroform fraction of the leaves was carried out using the solvent system Toluene: Ethyl...
This review article investigates the prevalent existence of suicide along with its risk factors and contributing factors leading to the culmination of them all, in an attempt to look behind the black curtain. Suicide is the result of an unbalanced scale between the good and bad. Every year 300,000 teenagers attempt and succeed at suicide worldwide. A set of emotions and unpleasant thoughts develop...
Selaginella bryopteris (L.) Bak. usually known as “Sanjeevani’, is a lithophyte with remarkable resurrection capabilities and medicinal properties. It is traditionally used for curing wounds and irregular menstruation, uterine disorders and other internal injuries. It contains a variety of secondary metabolites such as alkaloids, phenol and terpenoids etc due to which it can act as antioxidant...
HISTAMINE SUBTYPE 3 RECEPTOR ANTAGONISTS: CURRENT STATUS WITH FUTURE PROSPECTS IN DRUG DISCOVERY AND DRUG DEVELOPMENT
The histamine H3 receptor is an G protein-coupled receptor that regulates neurotransmission in the central nervous system and plays a major role in cognitive and homeostatic functions. The third histamine receptor was discovered in 1983 by a traditional pharmacological approach, consisting of assessing the inhibitory effect of histamine on its own release from depolarized rat...
PHYTOCHEMICAL ANALYSIS AND ANTICANCER ACTIVITY OF LEAF EXTRACT OF MANGIFERA INDICA (KOTTUKONAM VARIKA)
About 6 extract (methanol, acetone, hexane, ethyl acetate, hexane-ethyl acetate, aqueous extraction) from the leaves of Mangifera indica was extracted. Hexane-ethyl acetate was characterized by Gas Chromatography- Mass Spectroscopy. Ten constituents from 10 peaks were identified. Terpinyl acetate (5.80%) and phytol isomer (5.12%) are as the major constituents and the minor constituents like oxira...
Boswellia serrata Roxb. is known as kundur in Unani medicine, belongs to the family Burseraceae. The plant is widely distributed in India, it occurs in dry hilly forests of Rajasthan, Madhya Pradesh, Gujarat, Bihar, Assam, Orrisa, central peninsular regions of Andhra Pradesh etc. In ancient times Hindus, Babylonians, Persians, Romans, Chinese, Greeks and the people of old American civilization use...