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FORMULATION AND DEVELOPMENT OF ENTERIC COATED TABLETS OF PREDNISOLONE AS A COLON TARGETED DRUG DELIVERY
In the present investigation an attempt was made to prevent ulcerative colitis and to improve the patient compliance by developing enteric coated (EC) tablets of prednisolone and to reduce the side effects of anti inflammatory drugs in G.I.T. by developing conventional tablets of prednisolone by wet granulation technique and the prepared prednisolone based tablets were coated with different ratios...
9720
2477
A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF LORNOXICAM EMPLOYING HP-β-CYCLODEXTRIN AND SURFACTANTS
Lornoxicam, a widely prescribed anti-inflammatory and analgesic drug belongs to class II under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. It is practically insoluble in water and aqueous fluids. As such its oral absorption is dissolution rate limited and it requires enhancement in solubility and dissolution rate for increasing its oral bioavailability...
9712
2013
ISOLATION AND CHARACTERISATION OF STIGMAST-5-EN-3-OL (β-SITOSTEROL) FROM CALOTROPIS PROCERA LATEX ETHYL ACETATE FRACTION FOR IMMUNOMODULATORY ACTIVITY
Aim of this study was to identify and characterise the bioactive principles from the latex of Calotropis procera which could influence cellular and humoral aspects of immune system which may influence immune disorders. Calotropis procera R.Br. (Asclepiadaceae), commonly known as milk weed or swallow-wort, is a medicinal plant widely used as a folk medicine in India. It exhibits a wide spectrum of ...
9708
2099
SYSTEMATIC STUDY OF TAMRA (COPPER) BHASMA PREPARED BY TRADITIONAL AYURVEDA METHOD
Bhasmas, the formulations, which can be prepared from metals, minerals or even some marine products, are being used in Ayurvedic system of medicine. Copper (Tamra) is one such metal, used to prepare a bhasma, called “Tamra Bhasma” (TB) which is claimed to cure various diseased conditions. Though bhasmas are prepared since centuries, the exact mechanism of conversion of metal to its bhasma, esp...
9705
2888
EFFECT OF DRUG RELEASE ON ALBENDAZOLE CHEWABLE TABLETS BY USING DIFFERENT FORMULATION TECHNIQUES
In this research study, the effect of drug release of albendazole chewable tablets has been determined. The drug release is calculated by using the disintegration process, which is directly related to the hardness of tablets. The tablets are prepared by using three types of granulating methods are non-aqueous granulation, aqueous granulation, and direct compression. The tablets are evaluated by ca...
9699
3031
ISOLATION AND CHARACTERIZATION OF β-SITOSTEROL FROM METHANOLIC EXTRACT OF CORDIA DICHOTOMA LINN. BARK
Cordia dichotoma Linn. belonging the family Boraginaceae is locally called as Lasora in India. It is an important drug to cure diseases of the kidney, liver, spleen, heart and blood which attribute many medicinal properties in Ayurveda. The purpose of this study is to identify and characterize the bioactive principle from the bark of Cordia dichotoma Linn. Phytochemical screening methanolic extrac...
9694
2170
FORMULATION AND EVALUATION OF NANOSUSPENSION TO IMPROVE SOLUBILITY AND DISSOLUTION OF DIACEREIN
Diacerein is an Osteoarthritic drug that exhibited suboptimal oral bioavailability upon oral administration of conventional dosage form. Nanosuspension gaining more attention for improving oral bioavailability of such drugs. This study was aimed to enhance the solubility and dissolution of diacerein by preparing Nanosuspension. Diacerein Nanosuspension was prepared using combination of High Speed ...
9691
3045
SYNTHESIS AND CHARACTERISATION OF IBUPROFEN, KETOPROFEN PRODRUG FOR TASTE MASKING USING β- CYCLODEXTRIN
The Profens have indicated the gastrointestinal side effects due to the acidic moiety of the profen. The Profens are bitter in taste and it is omitted by mostly children. Therefore an attempt has been made to prepare the ester Prodrug using ethyl alcohol and butyl alcohol and its bitter taste is masked by using β-Cyclodextrin. The prepared prodrugs are characterised by melting point, UV and IR sp...
9675
2391
BIOSIMILAR: AN OVERVIEW
Biosimilars are defined as officially approved new version of innovator bio-therapeutic products for which the patent has expired. Biosimilars the ‘generic’ versions of biopharmaceuticals, continue to enter Indian pharmaceutical market, to treat a variety of diseases. Biosimilars available in India include monoclonal antibodies for treating various malignant and immunological disorders, growth...
9672
3149
COMPARATIVE EVALUATION OF DIFFERENT BRANDS OF ENTERIC-COATED DICLOFENAC SODIUM TABLETS
Diclofenac sodium is a non-steroidal anti-inflammatory drug with wide use in the treatment of rheumatic diseases. Enteric-coated tablet form of this drug has been developed to prevent the gastric irritation problem encountered with its use and to improve its efficacy. The enteric film coat resists solution in gastric fluid and disintegrates and releases the medication in the intestines. Many brand...
9669
2794